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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106249
Ensembl Protein ID YKR094C
UniProt Accession P0CH08; D6VVD9; P04838; P14796; P61864; Q6LA96; RL40A_YEAST
Genbank Protein ID CAA29195.1; CAA29196.1; CAA86130.1; DAA08405.1
Protein Name Ubiquitin-60S ribosomal protein L40; Ubiquitin; 60S ribosomal protein L40-A; CEP52; Large ribosomal subunit protein eL40-A
Genbank Nucleotide ID X05728; X05729; Z38059; BK006942
Gene Name RPL40A; UBI1; YIL148W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YKR094C YKR094C YKR094C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM UBQ_PIM 12826399
Classification
Family E-value Score Start End
ULD/UBL/NEDD8 9.30e-42 139.7 1 76
ULD/UDP/UBQ/UBQ_PIM 4.50e-29 98.7 1 73
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/NEDD8
   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           m+i+vktLtgk+i++e+e+sdti+++k ++++keGiPP+qqrli+aGkqled++t++dyn++k+s+LhLvL+LrGG
   Q: 1    MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76
           89*************************************************************************9 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           m+++vktl+gk+++lev+++dt+ ++K ki+++ g+pp+qq+LI+aGk+L+D +tLs+++i+++s++hlv++ 
   Q: 1    MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL 73
           99********************************************************************986 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     60S ribosomal protein L40-A: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2 (PubMed:23169626).
 60S ribosomal protein L40-A: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2 (PubMed:23169626).
Protein Sequence
(Fasta)
MQIFVKTLTG KTITLEVESS DTIDNVKSKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 60
IQKESTLHLV LRLRGGIIEP SLKALASKYN CDKSVCRKCY ARLPPRATNC RKRKCGHTNQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106249|ULD,NEDD8;ULD,UBQ_PIM|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCAAATGT ATGTTACGGC GAATACAGAA TACTATGTTC GAAATAATAT GAGGATTATA 60
CGATAGCAAA AAAGCCATAA ACGAAAGACA TAAATGGAAA ATGATTGACA AGCTCACAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106249|ULD,NEDD8;ULD,UBQ_PIM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0689--Ribosomal protein
KW-0832--Ubl conjugation
Interpro

IPR001975--Ribosomal_L40e
IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
Pfam

PF01020--Ribosomal_L40e
PF00240--ubiquitin
PRINTS

PR00348--UBIQUITIN
SMART

SM01377--Ribosomal_L40e
SM00213--UBQ
Gene Ontology

GO:0022625--C:cytosolic large ribosomal subunit
GO:0005634--C:nucleus
GO:0031386--F:protein tag
GO:0003735--F:structural constituent of ribosome
GO:0002181--P:cytoplasmic translation
GO:0016567--P:protein ubiquitination
GO:0000027--P:ribosomal large subunit assembly
GO:0000055--P:ribosomal large subunit export from nucleus
GO:0042254--P:ribosome biogenesis
KEGG sce:YIL148W; sce:YKR094C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001006 Aegilops tauschii 60.26 8.00e-46 173.00
IUUC-Aml-001246 Ailuropoda melanoleuca 89.84 7.00e-66 239.00
IUUC-Atr-003081 Amborella trichopoda 71.32 4.00e-44 167.00
IUUC-Apl-004069 Anas platyrhynchos 86.75 3.00e-40 153.00
IUUC-Ath-007098 Arabidopsis thaliana 89.84 1.00e-65 239.00
IUUC-Ago-007932 Ashbya gossypii 98.44 8.00e-72 259.00
IUUC-Acl-008350 Aspergillus clavatus 89.47 3.00e-67 244.00
IUUC-Afl-008554 Aspergillus flavus 95.31 7.00e-71 257.00
IUUC-Afu-008984 Aspergillus fumigatus 94.53 1.00e-69 252.00
IUUC-Ang-009609 Aspergillus niger 96.09 1.00e-70 256.00
IUUC-Aor-009991 Aspergillus oryzae 93.70 1.00e-68 249.00
IUUC-Ate-010252 Aspergillus terreus 96.00 1.00e-69 254.00
IUUC-Ame-010785 Astyanax mexicanus 89.36 8.00e-48 179.00
IUUC-Bgr-012115 Blumeria graminis 92.00 1.00e-66 243.00
IUUC-Bta-013360 Bos taurus 89.84 7.00e-66 239.00
IUUC-Bci-013851 Botrytis cinerea 94.53 5.00e-70 253.00
IUUC-Bdi-014499 Brachypodium distachyon 89.84 4.00e-66 240.00
IUUC-Bol-015961 Brassica oleracea 90.62 3.00e-66 241.00
IUUC-Cel-018677 Caenorhabditis elegans 89.06 4.00e-66 240.00
IUUC-Cja-019572 Callithrix jacchus 89.84 7.00e-66 239.00
IUUC-Cfa-020339 Canis familiaris 89.84 7.00e-66 239.00
IUUC-Cpo-021534 Cavia porcellus 89.84 7.00e-66 239.00
IUUC-Cre-022567 Chlamydomonas reinhardtii 89.84 2.00e-65 238.00
IUUC-Csa-023398 Chlorocebus sabaeus 89.84 7.00e-66 239.00
IUUC-Cin-025266 Ciona intestinalis 89.84 4.00e-66 240.00
IUUC-Csv-026105 Ciona savignyi 89.76 8.00e-66 239.00
IUUC-Cgl-026502 Colletotrichum gloeosporioides 97.60 2.00e-69 254.00
IUUC-Cne-026913 Cryptococcus neoformans 94.53 1.00e-69 252.00
IUUC-Cme-027344 Cyanidioschyzon merolae 93.41 5.00e-46 174.00
IUUC-Dre-028761 Danio rerio 89.84 1.00e-65 239.00
IUUC-Dno-028899 Dasypus novemcinctus 89.84 4.00e-65 237.00
IUUC-Dor-030658 Dipodomys ordii 96.05 4.00e-39 150.00
IUUC-Dme-031588 Drosophila melanogaster 91.41 1.00e-66 242.00
IUUC-Ete-033120 Echinops telfairi 89.84 7.00e-66 239.00
IUUC-Eca-033787 Equus caballus 89.84 7.00e-66 239.00
IUUC-Fca-035725 Felis catus 89.84 7.00e-66 239.00
IUUC-Fox-037870 Fusarium oxysporum 97.66 2.00e-71 258.00
IUUC-Fso-038461 Fusarium solani 100.00 7.00e-43 162.00
IUUC-Gmo-039163 Gadus morhua 90.62 3.00e-66 241.00
IUUC-Ggr-040034 Gaeumannomyces graminis 97.66 2.00e-71 259.00
IUUC-Gga-040909 Gallus gallus 88.28 3.00e-65 237.00
IUUC-Gac-041640 Gasterosteus aculeatus 90.62 3.00e-66 241.00
IUUC-Gma-043254 Glycine max 90.62 7.00e-67 243.00
IUUC-Ggo-045411 Gorilla gorilla 89.84 7.00e-66 239.00
IUUC-Hsa-046609 Homo sapiens 70.80 3.00e-50 188.00
IUUC-Hvu-047579 Hordeum vulgare 71.32 2.00e-51 192.00
IUUC-Itr-048586 Ictidomys tridecemlineatus 89.84 2.00e-66 243.00
IUUC-Kpa-049279 Komagataella pastoris 98.44 1.00e-71 259.00
IUUC-Lch-049971 Latimeria chalumnae 90.62 1.00e-66 243.00
IUUC-Lpe-051472 Leersia perrieri 81.20 2.00e-52 198.00
IUUC-Loc-052117 Lepisosteus oculatus 90.62 2.00e-66 241.00
IUUC-Lma-053049 Leptosphaeria maculans 96.88 7.00e-71 256.00
IUUC-Laf-054284 Loxodonta africana 89.84 2.00e-66 243.00
IUUC-Mcc-055710 Macaca mulatta 88.46 7.00e-65 238.00
IUUC-Meu-056411 Macropus eugenii 89.84 7.00e-66 239.00
IUUC-Mor-057008 Magnaporthe oryzae 96.88 4.00e-71 257.00
IUUC-Mpo-057360 Magnaporthe poae 96.09 1.00e-70 255.00
IUUC-Mtr-058437 Medicago truncatula 90.62 2.00e-66 241.00
IUUC-Mla-059080 Melampsora laricipopulina 91.00 8.00e-51 189.00
IUUC-Mmr-061335 Microcebus murinus 84.38 2.00e-59 218.00
IUUC-Mdo-062752 Monodelphis domestica 89.84 7.00e-66 239.00
IUUC-Mmu-063548 Mus musculus 89.84 2.00e-66 243.00
IUUC-Mac-065626 Musa acuminata 89.84 9.00e-66 239.00
IUUC-Mpu-066513 Mustela putorius furo 89.84 7.00e-66 239.00
IUUC-Mlu-068010 Myotis lucifugus 88.28 2.00e-64 235.00
IUUC-Nfi-068358 Neosartorya fischeri 96.03 2.00e-69 251.00
IUUC-Ncr-068799 Neurospora crassa 96.88 8.00e-71 256.00
IUUC-Opr-070655 Ochotona princeps 89.84 7.00e-66 239.00
IUUC-Ont-072180 Oreochromis niloticus 90.48 4.00e-65 237.00
IUUC-Oan-073196 Ornithorhynchus anatinus 89.84 7.00e-66 239.00
IUUC-Oba-075092 Oryza barthii 90.62 2.00e-66 241.00
IUUC-Obr-076156 Oryza brachyantha 90.62 2.00e-66 242.00
IUUC-Ogl-077471 Oryza glaberrima 90.62 2.00e-66 241.00
IUUC-Ogu-078259 Oryza glumaepatula 90.62 2.00e-66 241.00
IUUC-Oin-079901 Oryza indica 90.62 2.00e-66 241.00
IUUC-Ome-081343 Oryza meridionalis 90.62 2.00e-66 241.00
IUUC-Oni-082301 Oryza nivara 83.17 7.00e-35 137.00
IUUC-Opu-083839 Oryza punctata 66.42 9.00e-37 146.00
IUUC-Oru-085252 Oryza rufipogon 90.62 2.00e-66 241.00
IUUC-Osa-085747 Oryza sativa 79.85 4.00e-52 194.00
IUUC-Ola-086333 Oryzias latipes 90.62 2.00e-66 241.00
IUUC-Olu-087819 Ostreococcus lucimarinus 86.72 1.00e-63 233.00
IUUC-Oga-088027 Otolemur garnettii 89.84 7.00e-66 239.00
IUUC-Oar-090419 Ovis aries 89.84 7.00e-66 239.00
IUUC-Ptr-091593 Pan troglodytes 89.84 7.00e-66 239.00
IUUC-Pan-091806 Papio anubis 86.72 4.00e-62 227.00
IUUC-Psi-093654 Pelodiscus sinensis 89.84 7.00e-66 239.00
IUUC-Ppa-095174 Physcomitrella patens 89.84 9.00e-66 239.00
IUUC-Pfo-096492 Poecilia formosa 90.62 3.00e-66 241.00
IUUC-Pab-098004 Pongo abelii 89.84 7.00e-66 239.00
IUUC-Pop-098929 Populus trichocarpa 89.84 8.00e-66 239.00
IUUC-Ppe-101497 Prunus persica 90.62 3.00e-66 241.00
IUUC-Pva-102945 Pteropus vampyrus 89.84 7.00e-66 239.00
IUUC-Pgr-103268 Puccinia graminis 92.19 1.00e-68 250.00
IUUC-Ptt-103804 Puccinia triticina 92.08 5.00e-53 197.00
IUUC-Pte-104101 Pyrenophora teres 95.31 6.00e-70 254.00
IUUC-Pyt-104639 Pyrenophora triticirepentis 95.31 9.00e-70 252.00
IUUC-Rno-105290 Rattus norvegicus 89.84 7.00e-66 239.00
IUUC-Sha-106570 Sarcophilus harrisii 89.84 7.00e-66 239.00
IUUC-Sja-107834 Schizosaccharomyces japonicus 96.88 7.00e-71 256.00
IUUC-Spo-108045 Schizosaccharomyces pombe 96.88 5.00e-71 256.00
IUUC-Ssl-108670 Sclerotinia sclerotiorum 95.31 3.00e-70 254.00
IUUC-Sit-110085 Setaria italica 88.10 7.00e-65 238.00
IUUC-Sly-111884 Solanum lycopersicum 89.84 8.00e-66 239.00
IUUC-Stu-112385 Solanum tuberosum 89.26 6.00e-62 226.00
IUUC-Sar-112942 Sorex araneus 89.06 2.00e-65 238.00
IUUC-Sbi-114790 Sorghum bicolor 89.84 8.00e-66 239.00
IUUC-Sre-114908 Sporisorium reilianum 94.53 2.00e-69 251.00
IUUC-Ssc-116417 Sus scrofa 89.84 7.00e-66 239.00
IUUC-Tru-117557 Takifugu rubripes 90.62 3.00e-66 241.00
IUUC-Tni-119715 Tetraodon nigroviridis 90.62 3.00e-66 241.00
IUUC-Tca-121404 Theobroma cacao 90.62 3.00e-66 241.00
IUUC-Tvi-122611 Trichoderma virens 96.09 9.00e-71 256.00
IUUC-Tae-123019 Triticum aestivum 73.25 3.00e-61 224.00
IUUC-Tur-126527 Triticum urartu 89.84 4.00e-66 240.00
IUUC-Tme-127138 Tuber melanosporum 96.80 1.00e-69 252.00
IUUC-Tbe-127851 Tupaia belangeri 96.05 2.00e-39 151.00
IUUC-Ttr-128939 Tursiops truncatus 89.84 7.00e-66 239.00
IUUC-Uma-129619 Ustilago maydis 94.53 2.00e-69 251.00
IUUC-Vda-129775 Verticillium dahliae 96.83 1.00e-69 253.00
IUUC-Vvi-131414 Vitis vinifera 90.62 3.00e-66 241.00
IUUC-Xtr-131921 Xenopus tropicalis 89.84 7.00e-66 239.00
IUUC-Xma-134071 Xiphophorus maculatus 90.62 3.00e-66 241.00
IUUC-Yli-134671 Yarrowia lipolytica 96.88 3.00e-71 257.00
Created Date 25-Jun-2017

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