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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045763
Ensembl Protein ID ENSP00000369254.3
UniProt Accession Q8NFP9; B7Z2H9; Q5T320; Q9HCM8; Q9NSU1; Q9NW98; Q9Y6J1; NBEA_HUMAN
Genbank Protein ID AAM53531.1; BAA91485.1; BAH11865.1; CAH71883.1; CAH71883.1; CAI17183.1; CAI17183.1; BAB13370.1; CAB70903.2; AAD41633.1
Protein Name Neurobeachin; Lysosomal-trafficking regulator 2; Protein BCL8B
Genbank Nucleotide ID AF467288; AL138690; AK294737; AL139083; AL390071; AL159160; AL139083; AB046764; AL137748; AF072371
Gene Name NBEA; BCL8B; KIAA1544; LYST2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000172915.18 ENST00000379939.6 ENSP00000369271.1
ENSG00000172915.18 ENST00000379922.3 ENSP00000369254.3
ENSG00000172915.18 ENST00000400445.7 ENSP00000383295.3
ENSG00000172915.18 ENST00000310336.8 ENSP00000308534.5
ENSG00000172915.18 ENST00000629018.2 ENSP00000486239.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-06 29.0 296 329
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf......sdtllvsGsdDgtikvW 28
           gH d vtcla        d+++vsGs+D t+ +W
   Q: 296  GHWDVVTCLARsesyigGDCYIVSGSRDATLLLW 329
           68899***97667779766*************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).
 Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).
Protein Sequence
(Fasta)
MFVNSNGYNL GVREDEVVVN DVDLPPWAKK PEDFVRINRM ALESEFVSCQ LHQWIDLIFG 60
YKQRGPEAVR ALNVFHYLTY EGSVNLDSIT DPVLREIPEA YFIRDPHTFL LTKDFIKAME 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045763|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCAGGGGG CGGCAACATG GCGGAGTGAG CGGCGGCGTC GGGGCTTCAC AACAACAGTG 60
GTGGCCGTAG CAGCGGCGGC AGCAGCGTCA ATAGCATCGG CCACAGCCTG AGCTTCAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045763|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR013320--ConA-like_dom
IPR010508--DUF1088
IPR031570--DUF4704
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS50294--WD_REPEATS_REGION
Pfam

PF02138--Beach
PF06469--DUF1088
PF15787--DUF4704
PF14844--PH_BEACH
SMART

SM01026--Beach
SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0008104--P:protein localization
KEGG hsa:26960
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003632 Anas platyrhynchos 69.74 0.00e+00 738.00
IUUC-Aca-005124 Anolis carolinensis 69.47 0.00e+00 775.00
IUUC-Ame-011487 Astyanax mexicanus 93.60 0.00e+00 805.00
IUUC-Bta-012509 Bos taurus 69.47 0.00e+00 779.00
IUUC-Cja-018820 Callithrix jacchus 99.81 0.00e+00 1064.00
IUUC-Cfa-020786 Canis familiaris 69.47 0.00e+00 775.00
IUUC-Cpo-021636 Cavia porcellus 68.19 0.00e+00 757.00
IUUC-Ete-032481 Echinops telfairi 60.88 0.00e+00 664.00
IUUC-Eca-033893 Equus caballus 70.42 0.00e+00 783.00
IUUC-Fca-035726 Felis catus 70.04 0.00e+00 764.00
IUUC-Fal-036871 Ficedula albicollis 68.87 0.00e+00 772.00
IUUC-Gga-041206 Gallus gallus 69.43 0.00e+00 786.00
IUUC-Itr-048852 Ictidomys tridecemlineatus 69.85 0.00e+00 775.00
IUUC-Lch-050342 Latimeria chalumnae 91.22 0.00e+00 1005.00
IUUC-Loc-052771 Lepisosteus oculatus 68.13 0.00e+00 768.00
IUUC-Laf-053724 Loxodonta africana 69.66 0.00e+00 777.00
IUUC-Mcc-055200 Macaca mulatta 70.23 0.00e+00 769.00
IUUC-Mga-059851 Meleagris gallopavo 68.49 0.00e+00 768.00
IUUC-Mmr-061252 Microcebus murinus 99.81 0.00e+00 1065.00
IUUC-Mdo-062727 Monodelphis domestica 70.42 0.00e+00 790.00
IUUC-Mmu-064194 Mus musculus 69.47 0.00e+00 757.00
IUUC-Mpu-066074 Mustela putorius furo 70.42 0.00e+00 780.00
IUUC-Mlu-067308 Myotis lucifugus 69.89 0.00e+00 790.00
IUUC-Oan-073413 Ornithorhynchus anatinus 70.29 0.00e+00 769.00
IUUC-Ocu-074483 Oryctolagus cuniculus 71.56 0.00e+00 809.00
IUUC-Ola-087242 Oryzias latipes 68.62 0.00e+00 765.00
IUUC-Oga-088409 Otolemur garnettii 70.04 0.00e+00 775.00
IUUC-Oar-089217 Ovis aries 69.66 0.00e+00 777.00
IUUC-Pca-100240 Procavia capensis 69.29 3.00e-175 610.00
IUUC-Rno-104971 Rattus norvegicus 69.08 0.00e+00 753.00
IUUC-Sha-107387 Sarcophilus harrisii 70.61 0.00e+00 785.00
IUUC-Tgu-117304 Taeniopygia guttata 69.06 0.00e+00 778.00
IUUC-Tru-118226 Takifugu rubripes 85.39 0.00e+00 918.00
IUUC-Tni-120595 Tetraodon nigroviridis 81.43 0.00e+00 775.00
Created Date 25-Jun-2017

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