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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046866
UUCD1 version UUC-HoS-00269
Ensembl Protein ID ENSP00000355195.2
UniProt Accession Q8WXK4; J3KP57; Q2M3D5; Q52LK4; Q6ISF9; Q8N8F5; ASB12_HUMAN
Genbank Protein ID AAL57349.1; BAC04888.1; CAI39932.1; EAX05414.1; AAH69436.1; AAH69555.1; AAH93883.1; AAI04947.1
Protein Name Ankyrin repeat and SOCS box protein 12
Genbank Nucleotide ID AF403030; AK096896; AL356317; CH471132; BC069436; BC069555; BC093883; BC104946
Gene Name ASB12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198881.9 ENST00000362002.2 ENSP00000355195.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbmicroRNATRANSFACTargetScan
RepTarmiRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16325183
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MRIVLQLAKM NLMDITKIFS LLQPDKEEED TDTEEKQALN QAVYDNDSYT LDQLLRQERY 60
KRFINSRSGW GVPGTPLRLA ASYGHLSCLQ VLLAHGADVD SLDVKAQTPL FTAVSHGHLD 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046866|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACTGACTCCT AGTCTTTCAA CGGCATTGTT AACAGTGGGA AACGAGAGCC CCAGCTGCTC 60
CAGGTTGGGG CCGTGGGGGC TCCCTAAGGA GGGGACACCA GGGCCCCAAT GTTTCACAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046866|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT

Pfam

PF00023--Ank
PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG hsa:142689
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001687 Ailuropoda melanoleuca 91.22 4.00e-159 553.00
IUUC-Apl-003316 Anas platyrhynchos 64.38 1.00e-115 409.00
IUUC-Aca-004677 Anolis carolinensis 62.78 3.00e-110 391.00
IUUC-Ame-011686 Astyanax mexicanus 62.74 2.00e-108 385.00
IUUC-Bta-013050 Bos taurus 90.20 1.00e-156 545.00
IUUC-Cfa-020331 Canis familiaris 92.16 8.00e-162 562.00
IUUC-Cpo-021837 Cavia porcellus 89.34 2.00e-161 561.00
IUUC-Csa-023302 Chlorocebus sabaeus 98.74 4.00e-175 607.00
IUUC-Dre-028542 Danio rerio 59.61 3.00e-104 371.00
IUUC-Dno-029108 Dasypus novemcinctus 93.73 3.00e-167 580.00
IUUC-Eca-033539 Equus caballus 92.79 5.00e-163 566.00
IUUC-Fca-035885 Felis catus 92.48 2.00e-161 561.00
IUUC-Fal-036760 Ficedula albicollis 65.37 8.00e-111 393.00
IUUC-Gmo-038774 Gadus morhua 58.96 8.00e-105 373.00
IUUC-Gga-040432 Gallus gallus 65.52 2.00e-120 425.00
IUUC-Gac-042345 Gasterosteus aculeatus 59.09 3.00e-94 338.00
IUUC-Ggo-044738 Gorilla gorilla 98.71 2.00e-169 587.00
IUUC-Itr-048720 Ictidomys tridecemlineatus 89.62 3.00e-161 560.00
IUUC-Lch-050001 Latimeria chalumnae 59.37 4.00e-113 400.00
IUUC-Laf-053954 Loxodonta africana 96.10 1.00e-165 575.00
IUUC-Meu-056024 Macropus eugenii 77.47 3.00e-113 401.00
IUUC-Mga-059306 Meleagris gallopavo 65.83 3.00e-122 431.00
IUUC-Mmr-060921 Microcebus murinus 93.73 9.00e-166 575.00
IUUC-Mdo-062338 Monodelphis domestica 74.05 4.00e-128 451.00
IUUC-Mmu-063534 Mus musculus 88.64 7.00e-155 539.00
IUUC-Mpu-066393 Mustela putorius furo 91.22 8.00e-161 559.00
IUUC-Mlu-067956 Myotis lucifugus 82.65 7.00e-151 527.00
IUUC-Nle-069144 Nomascus leucogenys 98.74 4.00e-175 607.00
IUUC-Opr-071120 Ochotona princeps 76.49 7.00e-126 443.00
IUUC-Ont-072016 Oreochromis niloticus 61.94 7.00e-101 360.00
IUUC-Ocu-074678 Oryctolagus cuniculus 94.04 4.00e-167 580.00
IUUC-Ola-086912 Oryzias latipes 60.71 2.00e-100 358.00
IUUC-Oga-087915 Otolemur garnettii 92.48 3.00e-163 567.00
IUUC-Ptr-091446 Pan troglodytes 98.74 9.00e-175 605.00
IUUC-Pan-092113 Papio anubis 98.73 3.00e-173 600.00
IUUC-Psi-093998 Pelodiscus sinensis 67.21 8.00e-121 426.00
IUUC-Pfo-097085 Poecilia formosa 60.06 7.00e-106 377.00
IUUC-Pab-098363 Pongo abelii 98.43 7.00e-175 606.00
IUUC-Pca-100842 Procavia capensis 90.28 2.00e-163 568.00
IUUC-Rno-105361 Rattus norvegicus 88.96 7.00e-156 542.00
IUUC-Sar-113567 Sorex araneus 66.14 2.00e-103 369.00
IUUC-Tgu-117142 Taeniopygia guttata 60.00 1.00e-61 229.00
IUUC-Tru-118185 Takifugu rubripes 60.19 1.00e-108 385.00
IUUC-Tni-120054 Tetraodon nigroviridis 59.62 7.00e-105 373.00
IUUC-Ttr-129120 Tursiops truncatus 93.42 3.00e-164 570.00
IUUC-Xtr-131874 Xenopus tropicalis 54.48 4.00e-81 294.00
Created Date 25-Jun-2017

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