iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.40e-15	57.8	24	91

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           +D+++vvg+++f+ah++vLaa+S  F+alf+    +++  +m++++ + v +e+f al++ +Yt++l +
   Q: 24   CDCVIVVGNRHFKAHRSVLAACSTHFRALFSVAEGDQT-MNMIQLDsEvVTAEAFAALIDMMYTSTLML 91
           8*****************************99998998.*******659****************9976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR ALFSVAEGDQ 60
TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL LAASHLHLNS VVKACKHYLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAACTGGC TGGAGGAGCT AGGGGACTAG AGGCGGGGTG GGAGGGGGGC GGGTGGAAGG 60
GGGAGGAAGT CCCGTAACGG AGACGCTGGT CAGGACGTTC CCACCTCCTC TGACACTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9925

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001658	Ailuropoda melanoleuca	96.60	0.00e+00	1263.00
IUUC-Apl-003460	Anas platyrhynchos	87.00	0.00e+00	1163.00
IUUC-Aca-004701	Anolis carolinensis	82.87	0.00e+00	1086.00
IUUC-Ame-010653	Astyanax mexicanus	46.04	7.00e-91	328.00
IUUC-Bta-012316	Bos taurus	95.27	0.00e+00	1212.00
IUUC-Cja-019320	Callithrix jacchus	98.08	0.00e+00	1206.00
IUUC-Cfa-020580	Canis familiaris	97.05	0.00e+00	1266.00
IUUC-Csa-023329	Chlorocebus sabaeus	99.56	0.00e+00	1264.00
IUUC-Cho-025011	Choloepus hoffmanni	96.01	0.00e+00	1224.00
IUUC-Dno-029184	Dasypus novemcinctus	96.90	0.00e+00	1227.00
IUUC-Dor-031049	Dipodomys ordii	94.24	0.00e+00	1198.00
IUUC-Ete-033139	Echinops telfairi	93.65	0.00e+00	1176.00
IUUC-Eca-034139	Equus caballus	96.75	0.00e+00	1296.00
IUUC-Eeu-034836	Erinaceus europaeus	93.65	0.00e+00	1177.00
IUUC-Fca-035614	Felis catus	96.75	0.00e+00	1264.00
IUUC-Fal-037658	Ficedula albicollis	81.74	0.00e+00	1048.00
IUUC-Gmo-039417	Gadus morhua	47.98	5.00e-139	488.00
IUUC-Gga-040275	Gallus gallus	86.41	0.00e+00	1184.00
IUUC-Gac-041488	Gasterosteus aculeatus	48.29	3.00e-146	512.00
IUUC-Ggo-045418	Gorilla gorilla	99.85	0.00e+00	1267.00
IUUC-Itr-048803	Ictidomys tridecemlineatus	96.90	0.00e+00	1258.00
IUUC-Lch-050061	Latimeria chalumnae	79.03	0.00e+00	1040.00
IUUC-Loc-052587	Lepisosteus oculatus	55.82	4.00e-101	362.00
IUUC-Laf-054444	Loxodonta africana	93.94	0.00e+00	1243.00
IUUC-Mcc-055058	Macaca mulatta	99.56	0.00e+00	1264.00
IUUC-Meu-056102	Macropus eugenii	87.30	0.00e+00	1168.00
IUUC-Mga-059253	Meleagris gallopavo	84.64	0.00e+00	1089.00
IUUC-Mmr-061500	Microcebus murinus	97.78	0.00e+00	1261.00
IUUC-Mdo-062548	Monodelphis domestica	87.74	0.00e+00	1184.00
IUUC-Mmu-063293	Mus musculus	93.06	0.00e+00	1147.00
IUUC-Mpu-066133	Mustela putorius furo	97.05	0.00e+00	1266.00
IUUC-Mlu-067567	Myotis lucifugus	94.98	0.00e+00	1271.00
IUUC-Nle-069674	Nomascus leucogenys	99.56	0.00e+00	1263.00
IUUC-Opr-070253	Ochotona princeps	93.50	0.00e+00	1190.00
IUUC-Ont-072112	Oreochromis niloticus	52.15	2.00e-156	546.00
IUUC-Ocu-074530	Oryctolagus cuniculus	94.83	0.00e+00	1237.00
IUUC-Ola-086415	Oryzias latipes	51.83	3.00e-148	518.00
IUUC-Oga-088227	Otolemur garnettii	97.64	0.00e+00	1261.00
IUUC-Ptr-091100	Pan troglodytes	99.70	0.00e+00	1267.00
IUUC-Psi-094069	Pelodiscus sinensis	88.04	0.00e+00	1179.00
IUUC-Pfo-096527	Poecilia formosa	42.14	2.00e-79	290.00
IUUC-Pab-098131	Pongo abelii	99.70	0.00e+00	1265.00
IUUC-Pva-102442	Pteropus vampyrus	96.01	0.00e+00	1246.00
IUUC-Rno-105895	Rattus norvegicus	93.06	0.00e+00	1156.00
IUUC-Sha-107241	Sarcophilus harrisii	88.04	0.00e+00	1187.00
IUUC-Sar-113455	Sorex araneus	95.57	0.00e+00	1251.00
IUUC-Tgu-116468	Taeniopygia guttata	74.12	0.00e+00	910.00
IUUC-Tru-118352	Takifugu rubripes	51.31	5.00e-161	561.00
IUUC-Tsy-119340	Tarsius syrichta	97.05	0.00e+00	1262.00
IUUC-Tni-120226	Tetraodon nigroviridis	49.45	1.00e-157	550.00
IUUC-Ttr-128206	Tursiops truncatus	95.86	0.00e+00	1249.00
IUUC-Xtr-132726	Xenopus tropicalis	74.89	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence