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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046699
UUCD1 version UUC-HoS-01190
Ensembl Protein ID ENSP00000428209.1
UniProt Accession Q15819; UB2V2_HUMAN
Genbank Protein ID CAA66717.1; AAC05381.1; AAB04758.2; AAP35390.1; CAG28556.1; AAH07051.1; AAH16332.1; AAH16710.1; AAH28673.1; AAH62418.1
Protein Name Ubiquitin-conjugating enzyme E2 variant 2; DDVit 1; Enterocyte differentiation-associated factor 1; Enterocyte differentiation-promoting factor 1; MMS2 homolog; Vitamin D3-inducible protein
Genbank Nucleotide ID X98091; AF049140; U62136; BT006744; CR407628; BC007051; BC016332; BC016710; BC028673; BC062418
Gene Name UBE2V2; MMS2; UEV2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000169139.11 ENST00000523111.6 ENSP00000428209.1
ENSG00000169139.11 ENST00000523432.5 ENSP00000430019.1
ENSG00000169139.11 ENST00000518360.5 ENSP00000430491.1
ENSG00000169139.11 ENST00000520595.2 ENSP00000430741.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UEV E2_UEV 17108083; 21143188
Classification
Family E-value Score Start End
E2/UBC 6.40e-19 69.8 30 136
E2/UEV 2.20e-65 220.6 5 143
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UBC
   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsvesv 101
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + +l    kW+  +s++ v
   Q: 30   TVSWGLEDDEDmtLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSsGMVdarSIPVL---AKWQNSYSIKVV 118
           456667777776689******************************************99999999899943335555...7*********** PP
   S: 102  llsiqsll.aepnpespl 118
           l ++ +l+ ++ n++ p+
   Q: 119  LQELRRLMmSKENMKLPQ 136
           ******996667777775 PP
   

   E2/UEV
   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnG 98
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt+ye+rIy+lk+++g+kYPe+PP vrf++kinm+++n+s+G
   Q: 5    TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSG 96
           689***************************************************************************************** PP
   S: 99   vvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           +vd+r++pvLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 97   MVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTY 143
           ********************************************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
 Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Protein Sequence
(Fasta)
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN 60
RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046699|E2,E2/UEV|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGCGCGAC GGTTCGTGCG TGCGTGCGGG CGGCTGCGTC GGGCTGCAGG AGAAGATGGC 60
GGTCTCCACA GGTCGGTTCC CGGGCCGGGC TGCGTGATTT TCCGCTCCGA CCCGGCTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046699|E2,E2/UEV|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031372--C:UBC13-MMS2 complex
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008283--P:cell proliferation
GO:0000729--P:DNA double-strand break processing
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0042275--P:error-free postreplication DNA repair
GO:0070911--P:global genome nucleotide-excision repair
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0045739--P:positive regulation of DNA repair
GO:0010976--P:positive regulation of neuron projection development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051965--P:positive regulation of synapse assembly
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0006282--P:regulation of DNA repair
KEGG hsa:7336
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001275 Ailuropoda melanoleuca 100.00 6.00e-80 288.00
IUUC-Apl-003790 Anas platyrhynchos 98.56 2.00e-70 257.00
IUUC-Aca-004448 Anolis carolinensis 97.12 4.00e-69 253.00
IUUC-Aly-006115 Arabidopsis lyrata 54.14 1.00e-37 149.00
IUUC-Ani-009325 Aspergillus nidulans 49.65 3.00e-36 143.00
IUUC-Ang-009631 Aspergillus niger 50.00 4.00e-35 140.00
IUUC-Ate-010471 Aspergillus terreus 44.93 3.00e-29 120.00
IUUC-Bta-012471 Bos taurus 100.00 1.00e-82 298.00
IUUC-Cja-019506 Callithrix jacchus 99.31 2.00e-82 297.00
IUUC-Cfa-020370 Canis familiaris 100.00 1.00e-82 298.00
IUUC-Cpo-021317 Cavia porcellus 97.24 3.00e-80 290.00
IUUC-Csa-023412 Chlorocebus sabaeus 100.00 1.00e-82 298.00
IUUC-Cho-025024 Choloepus hoffmanni 100.00 2.00e-49 186.00
IUUC-Cin-025219 Ciona intestinalis 49.04 2.00e-25 107.00
IUUC-Dre-028062 Danio rerio 93.79 9.00e-79 285.00
IUUC-Dno-029546 Dasypus novemcinctus 100.00 5.00e-80 289.00
IUUC-Dse-031272 Dothistroma septosporum 49.28 6.00e-34 136.00
IUUC-Fca-035746 Felis catus 100.00 8.00e-80 288.00
IUUC-Fal-037369 Ficedula albicollis 97.24 5.00e-71 259.00
IUUC-Gmo-039696 Gadus morhua 84.03 3.00e-68 249.00
IUUC-Ggr-039839 Gaeumannomyces graminis 46.50 3.00e-30 124.00
IUUC-Gga-040634 Gallus gallus 97.24 5.00e-71 259.00
IUUC-Gac-041936 Gasterosteus aculeatus 82.64 3.00e-61 227.00
IUUC-Ggo-044696 Gorilla gorilla 100.00 1.00e-82 298.00
IUUC-Itr-048151 Ictidomys tridecemlineatus 100.00 1.00e-82 298.00
IUUC-Loc-052012 Lepisosteus oculatus 93.79 2.00e-78 284.00
IUUC-Lma-053194 Leptosphaeria maculans 50.72 4.00e-35 140.00
IUUC-Laf-053991 Loxodonta africana 99.29 2.00e-79 287.00
IUUC-Mcc-055850 Macaca mulatta 100.00 4.00e-80 289.00
IUUC-Mla-058919 Melampsora laricipopulina 53.24 4.00e-34 136.00
IUUC-Mga-059210 Meleagris gallopavo 98.56 1.00e-70 258.00
IUUC-Mmr-061751 Microcebus murinus 97.24 9.00e-80 288.00
IUUC-Mdo-062503 Monodelphis domestica 97.93 2.00e-73 267.00
IUUC-Mmu-063294 Mus musculus 98.62 8.00e-82 295.00
IUUC-Mpu-065942 Mustela putorius furo 100.00 1.00e-82 298.00
IUUC-Mlu-067702 Myotis lucifugus 100.00 8.00e-80 288.00
IUUC-Nle-069327 Nomascus leucogenys 100.00 1.00e-82 298.00
IUUC-Opr-070697 Ochotona princeps 84.17 1.00e-62 231.00
IUUC-Ont-072098 Oreochromis niloticus 88.89 7.00e-67 245.00
IUUC-Oan-073215 Ornithorhynchus anatinus 90.48 5.00e-67 246.00
IUUC-Ocu-073859 Oryctolagus cuniculus 100.00 1.00e-82 298.00
IUUC-Oba-075005 Oryza barthii 52.99 9.00e-38 149.00
IUUC-Ogl-077233 Oryza glaberrima 52.99 9.00e-38 149.00
IUUC-Ogu-078374 Oryza glumaepatula 52.99 9.00e-38 149.00
IUUC-Oin-079721 Oryza indica 52.99 9.00e-38 149.00
IUUC-Olo-080242 Oryza longistaminata 48.94 4.00e-39 154.00
IUUC-Ome-081761 Oryza meridionalis 52.99 6.00e-38 150.00
IUUC-Oni-082346 Oryza nivara 52.99 9.00e-38 149.00
IUUC-Opu-083148 Oryza punctata 52.99 9.00e-38 149.00
IUUC-Oru-084359 Oryza rufipogon 52.99 9.00e-38 149.00
IUUC-Osa-085664 Oryza sativa 52.99 9.00e-38 149.00
IUUC-Ola-087529 Oryzias latipes 87.50 5.00e-66 243.00
IUUC-Olu-087815 Ostreococcus lucimarinus 40.35 3.00e-20 90.90
IUUC-Oar-090010 Ovis aries 100.00 9.00e-80 288.00
IUUC-Ptr-091024 Pan troglodytes 100.00 9.00e-80 288.00
IUUC-Pan-091955 Papio anubis 100.00 1.00e-82 298.00
IUUC-Psi-093138 Pelodiscus sinensis 97.24 5.00e-71 259.00
IUUC-Pno-095070 Phaeosphaeria nodorum 51.45 5.00e-36 142.00
IUUC-Pfo-096483 Poecilia formosa 89.58 4.00e-67 246.00
IUUC-Pab-098753 Pongo abelii 100.00 1.00e-82 298.00
IUUC-Pva-102989 Pteropus vampyrus 100.00 1.00e-82 298.00
IUUC-Pgr-103617 Puccinia graminis 52.17 4.00e-32 130.00
IUUC-Ptt-104008 Puccinia triticina 44.93 3.00e-16 77.40
IUUC-Pte-104176 Pyrenophora teres 50.72 8.00e-36 142.00
IUUC-Pyt-104517 Pyrenophora triticirepentis 50.72 8.00e-36 142.00
IUUC-Rno-105839 Rattus norvegicus 99.31 5.00e-82 295.00
IUUC-Sce-106349 Saccharomyces cerevisiae 50.00 4.00e-33 133.00
IUUC-Sha-106779 Sarcophilus harrisii 96.55 3.00e-72 263.00
IUUC-Sar-113406 Sorex araneus 70.00 9.00e-49 185.00
IUUC-Ssc-115259 Sus scrofa 97.92 1.00e-80 291.00
IUUC-Tgu-116732 Taeniopygia guttata 98.55 5.00e-70 256.00
IUUC-Tru-118526 Takifugu rubripes 87.68 1.00e-54 205.00
IUUC-Tni-120169 Tetraodon nigroviridis 84.83 2.00e-55 207.00
IUUC-Tbe-127265 Tupaia belangeri 93.57 6.00e-65 239.00
IUUC-Ttr-128959 Tursiops truncatus 99.31 2.00e-82 297.00
IUUC-Uma-129419 Ustilago maydis 51.82 1.00e-34 138.00
IUUC-Xtr-131975 Xenopus tropicalis 93.10 2.00e-78 284.00
IUUC-Xma-133222 Xiphophorus maculatus 89.58 3.00e-67 247.00
IUUC-Yli-134591 Yarrowia lipolytica 51.49 1.00e-28 117.00
Created Date 25-Jun-2017

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