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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063284
Ensembl Protein ID ENSMUSP00000030212.8
UniProt Accession Q62420; Q3UTL7; Q3UY49; Q8BXS6; Q8VBV1; SH3G2_MOUSE
Genbank Protein ID AAC71774.1; AAL37407.1; AAL37408.1; BAC31888.1; BAE22364.1; BAE23963.1; CAM24397.1; CAM24397.1; CAM15712.1; CAM15712.1; AAH18385.1
Protein Name Endophilin-A1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3p4
Genbank Nucleotide ID U58886; AF326561; AF326562; AK044370; AK134970; AK139337; AL805970; AL806524; AL806524; AL805970; BC018385
Gene Name Sh3gl2; Een1; Sh3d2a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028488.15 ENSMUST00000030212.14 ENSMUSP00000030212.8
ENSMUSG00000028488.15 ENSMUST00000107188.9 ENSMUSP00000102806.3
ENSMUSG00000028488.15 ENSMUST00000107189.7 ENSMUSP00000102807.1
ENSMUSG00000028488.15 ENSMUST00000107184.7 ENSMUSP00000102802.1
ENSMUSG00000028488.15 ENSMUST00000133109.1 ENSMUSP00000117573.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.90e-15 57.1 294 345
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +++lyd+e++n++eL +k+Gd++++   ++ de+W +g   l+g++G+fP n+ve
   Q: 294  CCRALYDFEPENEGELGFKEGDIITLT--NQIDENWYEG--MLHGQSGFFPINYVE 345
           699***********************7..99********..8*************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472).
 Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472).
Protein Sequence
(Fasta)
MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI MTKTIEYLQP 60
NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF GRELGDDCNF GPALGEVGEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063284|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCCTGCTTT TCAACCACAG GGAGGCCAGG CTCAAAGGGC AAGGGCAGTG CGCAGGCAGC 60
ACCACTGCGG CTACCTGGGA GCTGGGTCAC CTGAGTCTAG ACTGCCCAAA GGCGGTGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063284|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA
SMART

SM00721--BAR
SM00326--SH3
Gene Ontology

GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0045202--C:synapse
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:1990416--P:cellular response to brain-derived neurotrophic factor stimulus
GO:0097484--P:dendrite extension
GO:0031175--P:neuron projection development
GO:0002090--P:regulation of receptor internalization
GO:0048488--P:synaptic vesicle endocytosis
GO:0016191--P:synaptic vesicle uncoating
KEGG mmu:20404
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001915 Ailuropoda melanoleuca 98.81 0.00e+00 687.00
IUUC-Apl-003760 Anas platyrhynchos 84.59 0.00e+00 642.00
IUUC-Aca-004816 Anolis carolinensis 89.17 0.00e+00 653.00
IUUC-Ame-011714 Astyanax mexicanus 77.56 1.00e-165 575.00
IUUC-Bgr-012305 Blumeria graminis 43.40 8.00e-11 63.20
IUUC-Bta-012465 Bos taurus 98.86 0.00e+00 719.00
IUUC-Cja-019054 Callithrix jacchus 98.86 0.00e+00 718.00
IUUC-Cfa-020276 Canis familiaris 98.74 0.00e+00 648.00
IUUC-Cpo-021492 Cavia porcellus 98.22 0.00e+00 685.00
IUUC-Csa-023432 Chlorocebus sabaeus 98.74 0.00e+00 649.00
IUUC-Cho-024348 Choloepus hoffmanni 96.59 0.00e+00 704.00
IUUC-Dre-028301 Danio rerio 75.28 2.00e-156 545.00
IUUC-Dno-029915 Dasypus novemcinctus 98.01 2.00e-177 614.00
IUUC-Dor-030855 Dipodomys ordii 88.72 2.00e-176 611.00
IUUC-Ete-032686 Echinops telfairi 89.32 7.00e-177 612.00
IUUC-Eca-033814 Equus caballus 98.82 0.00e+00 689.00
IUUC-Eeu-034924 Erinaceus europaeus 96.88 0.00e+00 700.00
IUUC-Fca-035895 Felis catus 98.52 0.00e+00 684.00
IUUC-Fal-037607 Ficedula albicollis 92.33 0.00e+00 681.00
IUUC-Gga-041254 Gallus gallus 90.93 0.00e+00 670.00
IUUC-Gac-041419 Gasterosteus aculeatus 76.56 1.00e-151 528.00
IUUC-Ggo-045606 Gorilla gorilla 98.86 0.00e+00 718.00
IUUC-Hsa-046258 Homo sapiens 98.86 0.00e+00 718.00
IUUC-Lch-049520 Latimeria chalumnae 76.97 3.00e-138 484.00
IUUC-Loc-052760 Lepisosteus oculatus 80.69 3.00e-158 551.00
IUUC-Mcc-055545 Macaca mulatta 98.23 0.00e+00 687.00
IUUC-Meu-056119 Macropus eugenii 96.31 0.00e+00 704.00
IUUC-Mmr-061111 Microcebus murinus 96.54 0.00e+00 684.00
IUUC-Mdo-062217 Monodelphis domestica 96.02 0.00e+00 701.00
IUUC-Mpu-066706 Mustela putorius furo 98.09 0.00e+00 641.00
IUUC-Mlu-067212 Myotis lucifugus 89.43 0.00e+00 671.00
IUUC-Ont-072622 Oreochromis niloticus 79.55 2.00e-169 587.00
IUUC-Oan-073674 Ornithorhynchus anatinus 95.27 0.00e+00 667.00
IUUC-Ocu-074005 Oryctolagus cuniculus 98.58 0.00e+00 716.00
IUUC-Ola-086840 Oryzias latipes 74.58 3.00e-152 530.00
IUUC-Oga-089025 Otolemur garnettii 95.71 0.00e+00 688.00
IUUC-Oar-089614 Ovis aries 98.82 0.00e+00 689.00
IUUC-Ptr-090943 Pan troglodytes 98.86 0.00e+00 718.00
IUUC-Pan-091990 Papio anubis 98.23 0.00e+00 687.00
IUUC-Psi-093052 Pelodiscus sinensis 90.91 0.00e+00 673.00
IUUC-Pva-102745 Pteropus vampyrus 97.73 0.00e+00 713.00
IUUC-Rno-105095 Rattus norvegicus 99.43 0.00e+00 723.00
IUUC-Sha-106694 Sarcophilus harrisii 94.30 0.00e+00 684.00
IUUC-Sar-113540 Sorex araneus 92.88 0.00e+00 643.00
IUUC-Ssc-116180 Sus scrofa 89.49 2.00e-173 601.00
IUUC-Tgu-117366 Taeniopygia guttata 92.05 0.00e+00 679.00
IUUC-Tru-118509 Takifugu rubripes 78.12 8.00e-167 579.00
IUUC-Vpa-130032 Vicugna pacos 84.03 7.00e-152 529.00
IUUC-Xtr-131877 Xenopus tropicalis 78.74 3.00e-161 561.00
Created Date 25-Jun-2017

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