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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046639
Ensembl Protein ID ENSP00000297533.4
UniProt Accession Q9BVT8; D3DX06; Q53AQ2; TMUB1_HUMAN
Genbank Protein ID AAU00156.1; AAK67645.1; AAQ88845.1; BAG36745.1; EAW54030.1; EAW54032.1; AAH00936.1; AAH33182.1
Protein Name Transmembrane and ubiquitin-like domain-containing protein 1; Dendritic cell-derived ubiquitin-like protein; Hepatocyte odd protein shuttling protein; Ubiquitin-like protein SB144; iHOPS
Genbank Nucleotide ID AY603380; AY037155; AY358481; AK314035; AC010973; CH471173; BC000936; BC033182
Gene Name TMUB1; C7orf21; DULP; HOPS; SB144; UNQ763/PRO1555
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164897.12 ENST00000297533.8 ENSP00000297533.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 4.10e-11 44.2 110 175
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 8    ldgs.eltlkvnpsdtVaeLKekiekklgip.pe.qqrLiykGkiL.eddktLadyglkdgstihllekksg 75
           l++s    +  +p+dt++ LK+     + +p +e q+rLiy+G++L +d +tL++++l++++++h+ +++++
   Q: 110  LNDSeQVAR-AWPHDTIGSLKR-----TQFPgREqQVRLIYQGQLLgDDTQTLGSLHLPPNCVLHCHVSTRV 175
           555533343.49**********.....9999988799******************************99986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).
 iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).
Protein Sequence
(Fasta)
MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS QPSAAMAATD 60
SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ EPLVLRLKFL NDSEQVARAW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046639|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATGCCCCGG GCCGCGGCGG CGGGGAAGGA GGGGTGCTTC AGGTGCCTGC GACCTCCGCG 60
CCTCCCGCCC GGAAGTGCCC GAGGGGCCGC GATGGAGCTG GGGGAGCCGG GCGGTGAGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046639|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0055037--C:recycling endosome
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:83590
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001821 Ailuropoda melanoleuca 92.28 2.00e-85 308.00
IUUC-Aca-004375 Anolis carolinensis 46.49 3.00e-33 135.00
IUUC-Bta-012542 Bos taurus 93.09 5.00e-77 280.00
IUUC-Cel-018429 Caenorhabditis elegans 39.81 3.00e-13 70.50
IUUC-Cja-019142 Callithrix jacchus 96.37 3.00e-82 298.00
IUUC-Cfa-020517 Canis familiaris 93.90 1.00e-91 328.00
IUUC-Cpo-021653 Cavia porcellus 88.26 3.00e-69 254.00
IUUC-Csa-023914 Chlorocebus sabaeus 97.97 2.00e-84 305.00
IUUC-Cin-025480 Ciona intestinalis 28.90 7.00e-13 67.80
IUUC-Csv-025923 Ciona savignyi 28.89 2.00e-14 72.80
IUUC-Dno-029028 Dasypus novemcinctus 92.68 1.00e-75 276.00
IUUC-Dor-030758 Dipodomys ordii 91.50 3.00e-81 294.00
IUUC-Ete-032267 Echinops telfairi 87.67 2.00e-52 197.00
IUUC-Eca-034010 Equus caballus 92.28 1.00e-77 282.00
IUUC-Fca-035402 Felis catus 93.50 1.00e-90 325.00
IUUC-Fal-037183 Ficedula albicollis 72.09 5.00e-13 66.20
IUUC-Gac-041487 Gasterosteus aculeatus 44.85 6.00e-39 154.00
IUUC-Ggo-045556 Gorilla gorilla 96.34 1.00e-80 292.00
IUUC-Itr-048729 Ictidomys tridecemlineatus 91.06 2.00e-86 311.00
IUUC-Laf-054495 Loxodonta africana 58.54 6.00e-36 143.00
IUUC-Mcc-055870 Macaca mulatta 98.37 3.00e-85 308.00
IUUC-Meu-056759 Macropus eugenii 71.43 7.00e-59 220.00
IUUC-Mdo-062740 Monodelphis domestica 71.43 4.00e-61 227.00
IUUC-Mmu-063171 Mus musculus 89.43 2.00e-74 271.00
IUUC-Mpu-066100 Mustela putorius furo 91.87 3.00e-86 311.00
IUUC-Mlu-067839 Myotis lucifugus 90.61 2.00e-79 288.00
IUUC-Nle-069603 Nomascus leucogenys 99.19 1.00e-85 309.00
IUUC-Opr-070539 Ochotona princeps 94.04 2.00e-44 171.00
IUUC-Ont-072413 Oreochromis niloticus 42.91 8.00e-39 153.00
IUUC-Ocu-074589 Oryctolagus cuniculus 91.53 2.00e-78 285.00
IUUC-Ola-087411 Oryzias latipes 44.57 1.00e-40 159.00
IUUC-Oga-088156 Otolemur garnettii 91.46 7.00e-84 303.00
IUUC-Oar-089302 Ovis aries 92.28 5.00e-75 274.00
IUUC-Ptr-091176 Pan troglodytes 100.00 3.00e-87 314.00
IUUC-Pab-098432 Pongo abelii 98.37 1.00e-81 296.00
IUUC-Pca-100595 Procavia capensis 68.33 1.00e-48 186.00
IUUC-Pva-102157 Pteropus vampyrus 49.10 7.00e-29 120.00
IUUC-Rno-105447 Rattus norvegicus 90.24 1.00e-82 299.00
IUUC-Sha-106499 Sarcophilus harrisii 73.47 3.00e-63 234.00
IUUC-Ssc-116410 Sus scrofa 91.46 3.00e-80 291.00
IUUC-Tgu-117495 Taeniopygia guttata 70.67 3.00e-25 107.00
IUUC-Tru-118609 Takifugu rubripes 43.75 1.00e-39 156.00
IUUC-Tni-120885 Tetraodon nigroviridis 45.88 5.00e-43 167.00
IUUC-Tbe-127898 Tupaia belangeri 89.92 3.00e-54 203.00
IUUC-Ttr-129209 Tursiops truncatus 92.68 4.00e-84 304.00
IUUC-Uma-129636 Ustilago maydis 44.90 3.00e-01 30.00
Created Date 25-Jun-2017

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