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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046361
Ensembl Protein ID ENSP00000261739.4
UniProt Accession Q8IZ07; O60736; AN13A_HUMAN
Genbank Protein ID AAH32833.2; AAC17109.1
Protein Name Ankyrin repeat domain-containing protein 13A; Protein KE03
Genbank Nucleotide ID BC032833; AF064604
Gene Name ANKRD13A; ANKRD13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000076513.16 ENST00000553025.5 ENSP00000474172.1
ENSG00000076513.16 ENST00000261739.8 ENSP00000261739.4
ENSG00000076513.16 ENST00000547639.5 ENSP00000449781.1
ENSG00000076513.16 ENST00000547419.6 ENSP00000474745.1
ENSG00000076513.16 ENST00000551491.1 ENSP00000447110.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 22298428
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 0.00024 22.4 551 567
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 3    deeLqlAlalSlqEeee 19
           d +LqlA++lS +E ee
   Q: 551  DNDLQLAMELSAKELEE 567
           88************887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Protein Sequence
(Fasta)
MSSACDAGDH YPLHLLVWKN DYRQLEKELQ GQNVEAVDPR GRTLLHLAVS LGHLESARVL 60
LRHKADVTKE NRQGWTVLHE AVSTGDPEMV YTVLQHRDYH NTSMALEGVP ELLQKILEAP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046361|UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGGCTAC TGGAGCAGGG GGAAAGAAGC TGGGGACAGG TAGACGGAAC TTTCCGCGTG 60
GAGATCTTTG GCCAAGAGAA TGAGCCTCAG CTCTGTTCTG TGGGCTGCAC TGAGTTTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046361|UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR021832--ANKRD13
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR003903--UIM_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM
Pfam

PF11904--GPCR_chapero_1
SMART

SM00248--ANK
SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005770--C:late endosome
GO:0005886--C:plasma membrane
KEGG hsa:88455
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003583 Anas platyrhynchos 76.22 0.00e+00 835.00
IUUC-Ame-011766 Astyanax mexicanus 61.96 0.00e+00 687.00
IUUC-Bta-012454 Bos taurus 93.55 0.00e+00 1033.00
IUUC-Cja-019299 Callithrix jacchus 98.05 0.00e+00 1127.00
IUUC-Cfa-020519 Canis familiaris 94.24 0.00e+00 1099.00
IUUC-Cpo-022361 Cavia porcellus 94.32 0.00e+00 1113.00
IUUC-Csa-023720 Chlorocebus sabaeus 99.28 0.00e+00 1137.00
IUUC-Cho-025017 Choloepus hoffmanni 90.68 0.00e+00 1046.00
IUUC-Dre-028557 Danio rerio 63.59 0.00e+00 707.00
IUUC-Dno-029547 Dasypus novemcinctus 93.23 0.00e+00 999.00
IUUC-Dor-030905 Dipodomys ordii 86.92 0.00e+00 966.00
IUUC-Ete-032445 Echinops telfairi 87.05 0.00e+00 974.00
IUUC-Eca-034374 Equus caballus 94.69 0.00e+00 1117.00
IUUC-Fca-035872 Felis catus 94.11 0.00e+00 1071.00
IUUC-Fal-037420 Ficedula albicollis 73.68 0.00e+00 825.00
IUUC-Gmo-039087 Gadus morhua 62.52 0.00e+00 696.00
IUUC-Gga-040676 Gallus gallus 74.23 0.00e+00 724.00
IUUC-Gac-042445 Gasterosteus aculeatus 62.12 0.00e+00 671.00
IUUC-Ggo-044701 Gorilla gorilla 99.47 0.00e+00 1139.00
IUUC-Itr-048701 Ictidomys tridecemlineatus 95.00 0.00e+00 883.00
IUUC-Lch-050665 Latimeria chalumnae 72.12 0.00e+00 629.00
IUUC-Loc-052905 Lepisosteus oculatus 65.27 0.00e+00 722.00
IUUC-Laf-053531 Loxodonta africana 93.59 0.00e+00 1100.00
IUUC-Mcc-054987 Macaca mulatta 99.64 0.00e+00 1134.00
IUUC-Meu-056395 Macropus eugenii 91.53 0.00e+00 1023.00
IUUC-Mla-059024 Melampsora laricipopulina 32.61 6.20e-01 29.60
IUUC-Mga-059750 Meleagris gallopavo 76.25 0.00e+00 870.00
IUUC-Mmr-061570 Microcebus murinus 94.62 0.00e+00 1109.00
IUUC-Mdo-062680 Monodelphis domestica 88.48 0.00e+00 1043.00
IUUC-Mmu-064293 Mus musculus 90.50 0.00e+00 1062.00
IUUC-Mpu-066697 Mustela putorius furo 94.14 0.00e+00 1080.00
IUUC-Mlu-067506 Myotis lucifugus 92.86 0.00e+00 1086.00
IUUC-Nle-069249 Nomascus leucogenys 99.82 0.00e+00 1146.00
IUUC-Opr-070751 Ochotona princeps 94.16 0.00e+00 1083.00
IUUC-Ont-072652 Oreochromis niloticus 64.09 0.00e+00 702.00
IUUC-Oan-073637 Ornithorhynchus anatinus 87.37 0.00e+00 867.00
IUUC-Ocu-074568 Oryctolagus cuniculus 94.10 0.00e+00 1070.00
IUUC-Ola-087282 Oryzias latipes 65.64 0.00e+00 677.00
IUUC-Oga-089125 Otolemur garnettii 88.27 0.00e+00 1021.00
IUUC-Oar-089947 Ovis aries 93.37 0.00e+00 1030.00
IUUC-Ptr-090995 Pan troglodytes 100.00 0.00e+00 1147.00
IUUC-Pan-091908 Papio anubis 98.75 0.00e+00 1123.00
IUUC-Psi-093017 Pelodiscus sinensis 74.46 0.00e+00 843.00
IUUC-Pfo-096285 Poecilia formosa 64.05 0.00e+00 713.00
IUUC-Pab-098541 Pongo abelii 100.00 0.00e+00 1147.00
IUUC-Pva-102946 Pteropus vampyrus 91.71 0.00e+00 1009.00
IUUC-Ptt-103794 Puccinia triticina 31.34 1.30e+00 28.90
IUUC-Rno-105860 Rattus norvegicus 90.78 0.00e+00 1043.00
IUUC-Sha-106472 Sarcophilus harrisii 91.17 0.00e+00 1011.00
IUUC-Sar-113275 Sorex araneus 80.34 0.00e+00 663.00
IUUC-Ssc-116021 Sus scrofa 96.38 0.00e+00 730.00
IUUC-Tgu-117508 Taeniopygia guttata 73.76 0.00e+00 845.00
IUUC-Tru-118161 Takifugu rubripes 63.00 0.00e+00 706.00
IUUC-Tsy-119511 Tarsius syrichta 89.52 0.00e+00 1019.00
IUUC-Tni-120857 Tetraodon nigroviridis 62.01 0.00e+00 692.00
IUUC-Tbe-128109 Tupaia belangeri 96.55 0.00e+00 1000.00
IUUC-Ttr-128175 Tursiops truncatus 90.05 0.00e+00 1026.00
IUUC-Vpa-130380 Vicugna pacos 74.83 9.00e-126 443.00
IUUC-Xtr-132267 Xenopus tropicalis 75.22 0.00e+00 868.00
Created Date 25-Jun-2017

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