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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104828
UUCD1 version UUC-RaN-01029
Ensembl Protein ID ENSRNOP00000014708.3
UniProt Accession Q8R424; STABP_RAT
Genbank Protein ID AAL92520.1; AAH61711.1
Protein Name STAM-binding protein; Associated molecule with the SH3 domain of STAM
Genbank Nucleotide ID AY083159; BC061711
Gene Name Stambp; Amsh
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000012227.7 ENSRNOT00000014708.5 ENSRNOP00000014708.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Jab_MPN 2.60e-55 186.5 256 381
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Jab_MPN
   S: 5    vvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvfdlldqeGlivlGWiHthpeelkfl 93
           ++v+p++l+  fl+l+++++a+++e++G+l+g+l+++++++t+vl+p+q++g +++++en+e++f ++d  Gl +lGWiHthp++++fl
   Q: 256  HIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFL 344
           89*************************************************************************************** PP
   S: 94   ssvdvathsslealkkrsvaivsspkfqelsafkltd 130
           ssvd++th+s+++++++s+aiv+spkfqe+++fkltd
   Q: 345  SSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTD 381
           ************************************9 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (By similarity).
 Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (By similarity).
Protein Sequence
(Fasta)
MSDHADVSLP PQDRVRILSQ LGSAVELNED IPPRRYFRSG VEIIRMASIY SEEGNIEHAF 60
ILYNKYITLF IEKLPKHRDY KSAIIPEKKD AVKKLKNVAF PKAEELKTEL LKRYTKEYEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104828|UBD,Jab_MPN|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTAGTCCACC CCTGCCATCC TGGGGACCGT GAGTGAGACA GACGACCTTT CCCTCAGTGC 60
ACATCCAAGA ATGTGTATTG AGTTTGGGAC CACAAGTCAT GGAGACGGAG CTAAGTAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104828|UBD,Jab_MPN|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
IPR007330--MIT
IPR015063--USP8_dimer
Pfam

PF01398--JAB
PF08969--USP8_dimer
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0032154--C:cleavage furrow
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000281--P:mitotic cytokinesis
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0014067--P:negative regulation of phosphatidylinositol 3-kinase signaling
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0016579--P:protein deubiquitination
KEGG rno:171565
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001743 Ailuropoda melanoleuca 81.37 8.00e-180 622.00
IUUC-Atr-002473 Amborella trichopoda 42.15 7.00e-44 171.00
IUUC-Apl-003743 Anas platyrhynchos 71.43 3.00e-173 600.00
IUUC-Aca-005310 Anolis carolinensis 68.06 3.00e-152 531.00
IUUC-Aly-005808 Arabidopsis lyrata 48.42 4.00e-46 179.00
IUUC-Afl-008565 Aspergillus flavus 54.36 1.00e-40 160.00
IUUC-Ani-009164 Aspergillus nidulans 55.03 4.00e-42 166.00
IUUC-Ang-009659 Aspergillus niger 53.69 5.00e-42 165.00
IUUC-Aor-010102 Aspergillus oryzae 54.36 1.00e-40 160.00
IUUC-Ate-010360 Aspergillus terreus 53.38 7.00e-42 165.00
IUUC-Ame-011255 Astyanax mexicanus 57.04 5.00e-139 487.00
IUUC-Bgr-012260 Blumeria graminis 49.72 1.00e-39 157.00
IUUC-Bta-012791 Bos taurus 80.73 2.00e-177 615.00
IUUC-Bol-015371 Brassica oleracea 48.21 5.00e-46 178.00
IUUC-Bra-017428 Brassica rapa 48.21 7.00e-46 178.00
IUUC-Cja-019600 Callithrix jacchus 84.43 0.00e+00 646.00
IUUC-Cfa-020125 Canis familiaris 71.73 6.00e-159 553.00
IUUC-Cpo-021625 Cavia porcellus 83.49 0.00e+00 676.00
IUUC-Csa-023635 Chlorocebus sabaeus 85.14 0.00e+00 671.00
IUUC-Cho-024997 Choloepus hoffmanni 66.04 1.00e-140 493.00
IUUC-Cin-025539 Ciona intestinalis 54.89 3.00e-54 206.00
IUUC-Csv-026138 Ciona savignyi 48.86 2.00e-52 199.00
IUUC-Dre-027611 Danio rerio 61.08 5.00e-137 480.00
IUUC-Dno-028859 Dasypus novemcinctus 83.25 0.00e+00 650.00
IUUC-Dme-031787 Drosophila melanogaster 55.33 7.00e-60 224.00
IUUC-Ete-032412 Echinops telfairi 72.88 7.00e-161 560.00
IUUC-Eca-033504 Equus caballus 82.55 3.00e-178 617.00
IUUC-Eeu-034539 Erinaceus europaeus 80.90 6.00e-138 483.00
IUUC-Fca-035810 Felis catus 83.25 0.00e+00 644.00
IUUC-Fal-037001 Ficedula albicollis 68.88 2.00e-135 474.00
IUUC-Fox-037879 Fusarium oxysporum 49.71 6.00e-39 155.00
IUUC-Fso-038095 Fusarium solani 52.17 8.00e-36 144.00
IUUC-Gmo-038927 Gadus morhua 65.62 1.00e-79 290.00
IUUC-Ggr-039788 Gaeumannomyces graminis 45.81 1.00e-37 151.00
IUUC-Gac-041538 Gasterosteus aculeatus 58.92 1.00e-144 505.00
IUUC-Ggo-045287 Gorilla gorilla 84.20 0.00e+00 664.00
IUUC-Hsa-046543 Homo sapiens 84.20 0.00e+00 662.00
IUUC-Hvu-047336 Hordeum vulgare 53.40 2.00e-28 119.00
IUUC-Itr-048682 Ictidomys tridecemlineatus 83.25 0.00e+00 656.00
IUUC-Lch-049666 Latimeria chalumnae 57.76 5.00e-138 484.00
IUUC-Loc-052848 Lepisosteus oculatus 69.63 4.00e-84 305.00
IUUC-Lma-053221 Leptosphaeria maculans 46.53 2.00e-38 154.00
IUUC-Laf-053773 Loxodonta africana 82.31 0.00e+00 630.00
IUUC-Mcc-055868 Macaca mulatta 85.14 0.00e+00 671.00
IUUC-Meu-056009 Macropus eugenii 74.94 4.00e-168 584.00
IUUC-Mor-057282 Magnaporthe oryzae 45.81 7.00e-39 155.00
IUUC-Mpo-057473 Magnaporthe poae 45.81 6.00e-38 152.00
IUUC-Mtr-058598 Medicago truncatula 50.00 1.00e-45 177.00
IUUC-Mla-058952 Melampsora laricipopulina 48.61 9.00e-10 54.30
IUUC-Mga-059613 Meleagris gallopavo 70.49 2.00e-174 605.00
IUUC-Mmu-063182 Mus musculus 97.64 0.00e+00 737.00
IUUC-Mac-065426 Musa acuminata 47.18 2.00e-43 170.00
IUUC-Mlu-067130 Myotis lucifugus 79.25 0.00e+00 661.00
IUUC-Ncr-068670 Neurospora crassa 47.56 1.00e-35 144.00
IUUC-Nle-069588 Nomascus leucogenys 84.91 0.00e+00 667.00
IUUC-Ont-072010 Oreochromis niloticus 60.97 1.00e-141 496.00
IUUC-Ocu-073794 Oryctolagus cuniculus 83.96 0.00e+00 625.00
IUUC-Oga-088669 Otolemur garnettii 83.25 0.00e+00 649.00
IUUC-Oar-089535 Ovis aries 80.73 4.00e-177 613.00
IUUC-Ptr-090610 Pan troglodytes 84.20 0.00e+00 663.00
IUUC-Pan-091821 Papio anubis 80.57 3.00e-175 607.00
IUUC-Psi-093278 Pelodiscus sinensis 70.33 5.00e-153 533.00
IUUC-Pma-094125 Petromyzon marinus 53.10 9.00e-109 387.00
IUUC-Ppa-095880 Physcomitrella patens 46.39 2.00e-44 174.00
IUUC-Pfo-096766 Poecilia formosa 60.00 2.00e-147 514.00
IUUC-Pab-097770 Pongo abelii 84.67 0.00e+00 668.00
IUUC-Pop-098795 Populus trichocarpa 50.00 1.00e-47 183.00
IUUC-Pca-100291 Procavia capensis 66.59 4.00e-145 507.00
IUUC-Ppe-101461 Prunus persica 44.14 6.00e-47 181.00
IUUC-Pva-102762 Pteropus vampyrus 83.49 0.00e+00 656.00
IUUC-Pgr-103491 Puccinia graminis 50.00 2.00e-36 147.00
IUUC-Ptt-103871 Puccinia triticina 50.33 4.00e-34 139.00
IUUC-Pyt-104611 Pyrenophora triticirepentis 50.89 3.00e-39 156.00
IUUC-Sha-107440 Sarcophilus harrisii 75.41 1.00e-157 549.00
IUUC-Sly-111040 Solanum lycopersicum 45.25 4.00e-46 179.00
IUUC-Stu-112649 Solanum tuberosum 44.80 2.00e-45 176.00
IUUC-Ssc-116248 Sus scrofa 83.25 0.00e+00 635.00
IUUC-Tgu-117057 Taeniopygia guttata 64.93 1.00e-137 483.00
IUUC-Tru-118459 Takifugu rubripes 62.24 9.00e-147 513.00
IUUC-Tsy-119283 Tarsius syrichta 73.15 2.00e-163 568.00
IUUC-Tni-120745 Tetraodon nigroviridis 61.14 3.00e-145 508.00
IUUC-Tca-121398 Theobroma cacao 44.40 2.00e-47 183.00
IUUC-Tre-121910 Trichoderma reesei 52.17 3.00e-37 149.00
IUUC-Tvi-122647 Trichoderma virens 52.90 2.00e-37 149.00
IUUC-Tbe-128135 Tupaia belangeri 83.81 5.00e-86 311.00
IUUC-Ttr-129114 Tursiops truncatus 81.53 1.00e-172 598.00
IUUC-Vvi-131419 Vitis vinifera 47.03 1.00e-47 184.00
Created Date 25-Jun-2017

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