iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21554762

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.10e-06	29.7	66	127
E3 activity/RING/RING	7.30e-05	24.3	70	108

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C+iCl  +++  + +pCgH f++ C+ + +           +CP++
   Q: 70   CPICLMALRE-AVQTPCGHRFCKACIiKSI------RDAGHKCPVD 108
           ********88.888***********97777......8888889997 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSSSDCC AAMAASCSAA VKDDSVSGSA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAAGGCGG AAGCAGCGGC GGCCGCGGCT GGGGCTGAGG CTCCGGCCGT CGGCGGACGC 60
AGCAGCCGCG GCCCACGAGC CGGGAGTTTG GCGTCGGAGC CACTTGGTCT CGGAGTGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0551--Lipid droplet
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0892--Osteogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0042826--F:histone deacetylase binding
GO:0042802--F:identical protein binding
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0043422--F:protein kinase B binding
GO:0019901--F:protein kinase binding
GO:0047485--F:protein N-terminus binding
GO:0004871--F:signal transducer activity
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0009887--P:animal organ morphogenesis
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0046849--P:bone remodeling
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006955--P:immune response
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0007254--P:JNK cascade
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043065--P:positive regulation of apoptotic process
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0070555--P:response to interleukin-1
GO:0007165--P:signal transduction
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

mmu:22034

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	86.88	0.00e+00	903.00
IUUC-Apl-004062	Anas platyrhynchos	73.55	0.00e+00	795.00
IUUC-Aca-004636	Anolis carolinensis	72.15	0.00e+00	771.00
IUUC-Ame-011682	Astyanax mexicanus	55.85	3.00e-164	571.00
IUUC-Bta-012692	Bos taurus	83.39	0.00e+00	922.00
IUUC-Bdi-014180	Brachypodium distachyon	25.14	2.00e-07	50.40
IUUC-Cja-019426	Callithrix jacchus	87.92	0.00e+00	928.00
IUUC-Cfa-020948	Canis familiaris	85.28	0.00e+00	797.00
IUUC-Cpo-021378	Cavia porcellus	86.56	0.00e+00	915.00
IUUC-Csa-024045	Chlorocebus sabaeus	87.74	0.00e+00	931.00
IUUC-Cho-024973	Choloepus hoffmanni	73.42	8.00e-94	337.00
IUUC-Csv-026300	Ciona savignyi	40.27	1.00e-45	176.00
IUUC-Dre-027557	Danio rerio	58.32	3.00e-173	601.00
IUUC-Dno-030032	Dasypus novemcinctus	81.90	4.00e-134	470.00
IUUC-Dor-030790	Dipodomys ordii	88.68	0.00e+00	934.00
IUUC-Dse-031478	Dothistroma septosporum	24.46	8.00e-11	62.00
IUUC-Dme-031921	Drosophila melanogaster	27.16	2.00e-40	159.00
IUUC-Ete-032952	Echinops telfairi	83.84	5.00e-164	570.00
IUUC-Eca-033924	Equus caballus	82.32	0.00e+00	826.00
IUUC-Eeu-034734	Erinaceus europaeus	81.73	0.00e+00	835.00
IUUC-Fca-036222	Felis catus	79.96	0.00e+00	798.00
IUUC-Fal-036834	Ficedula albicollis	73.25	0.00e+00	729.00
IUUC-Fox-037935	Fusarium oxysporum	30.70	8.00e-23	101.00
IUUC-Gmo-039061	Gadus morhua	62.20	1.00e-88	320.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.16	7.00e-13	68.90
IUUC-Gga-040599	Gallus gallus	73.98	0.00e+00	802.00
IUUC-Gac-041977	Gasterosteus aculeatus	54.44	3.00e-167	581.00
IUUC-Ggo-044508	Gorilla gorilla	83.27	0.00e+00	855.00
IUUC-Hsa-046349	Homo sapiens	87.92	0.00e+00	936.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	90.62	0.00e+00	939.00
IUUC-Lch-049821	Latimeria chalumnae	69.09	0.00e+00	724.00
IUUC-Loc-051995	Lepisosteus oculatus	60.92	0.00e+00	636.00
IUUC-Laf-054115	Loxodonta africana	82.26	0.00e+00	894.00
IUUC-Mcc-055298	Macaca mulatta	87.36	0.00e+00	926.00
IUUC-Mpo-057517	Magnaporthe poae	30.29	4.00e-15	76.30
IUUC-Mga-059340	Meleagris gallopavo	73.93	0.00e+00	801.00
IUUC-Mvi-060553	Microbotryum violaceum	28.57	2.00e-16	80.50
IUUC-Mmr-061063	Microcebus murinus	88.37	0.00e+00	926.00
IUUC-Mdo-062075	Monodelphis domestica	79.26	0.00e+00	862.00
IUUC-Mpu-065748	Mustela putorius furo	85.95	0.00e+00	912.00
IUUC-Mlu-067888	Myotis lucifugus	86.03	0.00e+00	914.00
IUUC-Nle-069234	Nomascus leucogenys	87.92	0.00e+00	933.00
IUUC-Opr-070393	Ochotona princeps	93.43	2.00e-119	422.00
IUUC-Ont-072459	Oreochromis niloticus	57.39	4.00e-174	604.00
IUUC-Oan-073578	Ornithorhynchus anatinus	79.23	0.00e+00	863.00
IUUC-Ocu-074201	Oryctolagus cuniculus	88.70	0.00e+00	939.00
IUUC-Ola-087319	Oryzias latipes	63.40	1.00e-90	327.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.84	4.00e-10	58.90
IUUC-Oga-087936	Otolemur garnettii	86.36	0.00e+00	914.00
IUUC-Oar-089379	Ovis aries	82.84	0.00e+00	916.00
IUUC-Ptr-090758	Pan troglodytes	88.30	0.00e+00	935.00
IUUC-Pan-092590	Papio anubis	87.55	0.00e+00	928.00
IUUC-Psi-093948	Pelodiscus sinensis	70.75	0.00e+00	795.00
IUUC-Pma-094434	Petromyzon marinus	44.24	4.00e-123	435.00
IUUC-Pfo-096912	Poecilia formosa	54.89	9.00e-167	580.00
IUUC-Pab-097651	Pongo abelii	88.30	0.00e+00	937.00
IUUC-Pop-099898	Populus trichocarpa	25.62	1.00e-08	54.70
IUUC-Pca-100958	Procavia capensis	83.46	0.00e+00	687.00
IUUC-Pva-103247	Pteropus vampyrus	89.68	7.00e-125	441.00
IUUC-Pte-104279	Pyrenophora teres	27.31	5.00e-14	73.20
IUUC-Pyt-104429	Pyrenophora triticirepentis	27.31	8.00e-13	68.60
IUUC-Rno-104994	Rattus norvegicus	95.85	0.00e+00	1017.00
IUUC-Sha-106494	Sarcophilus harrisii	80.94	0.00e+00	872.00
IUUC-Sar-113375	Sorex araneus	85.31	0.00e+00	897.00
IUUC-Sre-115218	Sporisorium reilianum	27.19	6.00e-15	76.30
IUUC-Ssc-115417	Sus scrofa	85.06	0.00e+00	927.00
IUUC-Tgu-117232	Taeniopygia guttata	74.15	0.00e+00	777.00
IUUC-Tru-118321	Takifugu rubripes	56.02	5.00e-171	594.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.67	9.00e-166	576.00
IUUC-Tbe-127719	Tupaia belangeri	76.69	0.00e+00	784.00
IUUC-Ttr-129264	Tursiops truncatus	89.86	4.00e-120	424.00
IUUC-Uma-129620	Ustilago maydis	27.24	2.00e-17	84.30
IUUC-Vpa-130244	Vicugna pacos	86.56	5.00e-123	434.00
IUUC-Xtr-131948	Xenopus tropicalis	64.70	0.00e+00	718.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence