iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064133

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 17-like protein A; Deubiquitinating enzyme 1; Ubiquitin carboxyl-terminal hydrolase DUB-1; Ubiquitin thioesterase DUB-1; Ubiquitin-specific-processing protease DUB-1

Genbank Nucleotide ID

U41636

Gene Name

Usp17la; Dub-1; Dub1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000054568.7	ENSMUST00000067695.7	ENSMUSP00000068997.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	10467179

Classification

Family	E-value	Score	Start	End
DUB/USP	1.10e-80	272.5	51	347

Active Site

Position(s)	Description	Evidence
60	Nucleophile
307	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsg 86
           +Gl+N gN+CY+N++LQcL+++p+l++++l+ ++++++      +p+g+ l++++ l+++ +  +++  +++p+++l++       f++
   Q: 51   CGLQNTGNSCYLNAALQCLTHTPPLADYMLSqEHSQTC-----CSPEGCKLCAMEALVTQSLlhSHSGDVMKPSHILTSA------FHK 128
           7******************************3333333.....47899999999999999887788888999*9988764......889 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
            +q+Da+Efl+f l++++e++                  l+ ++++k++++ +s+i+d+F+g ++sqikcl c+ +s +++ fld++l+
   Q: 129  HQQEDAHEFLMFTLETMHESC------------------LQVHRQSKPTSEDSSPIHDIFGGWWRSQIKCLLCQGTSDTYDRFLDIPLD 199
           9********************..................77888999****************************************** PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +++ +     s++++L +  k eel+g+n+yyc kc++k  a+k+l ++  P+vL++ L+Rfs        +k+++kv++p+ Ldl+p+
   Q: 200  ISSAQ-----SVKQALWDTEKSEELCGDNAYYCGKCRQKMPASKTLHVHIAPKVLMVVLNRFS----AFTGNKLDRKVSYPEFLDLKPY 279
           *****.....9***************************************************3....37889***************** PP
   S: 265  ctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++p+ +   +  Y L+av+vH G +++sGHY+++vk  +gkW+++dD+kVt ++ ++vl+   ++aYvlfY +
   Q: 280  LSEPTGG---PLPYALYAVLVHDGaTSHSGHYFCCVKAGHGKWYKMDDTKVTRCDVTSVLN---ENAYVLFYVQ 347
           ***9988...89*************************************************...********87 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Has deubiquitinating enzyme activity for DNAH5, suggesting a role in the regulation of DNAH5 degradation by the ubiquitin-proteasome pathway. Has growth-suppressing activity; induces arrest in G1 phase upon controlled expression.

Protein Sequence
(Fasta)

MVVALSFPEA DPALSSPDAP ELHQDEAQVV EELTVNGKHS LSWESPQGPG CGLQNTGNSC 60
YLNAALQCLT HTPPLADYML SQEHSQTCCS PEGCKLCAME ALVTQSLLHS HSGDVMKPSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGGAGAGG AAAAACTTCC TTCTGCTCCC TTAGAAGACT CCAGCTAGTT ATTTGAAGAG 60
GTCTTTGTAG ACACGGTGGT TGCTCTTTCC TCCCAAGAAG GTAAGTCTCA CTGTAAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:13531

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence