iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.00e-12	45.2	614	643

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           + v+cla+ ++   l+ G+ Dgt+ + D+ 
   Q: 614  SNVYCLAWsPNcLELAFGTFDGTVGILDVE 643
           78*******77677**************85 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Nuclear receptor cofactor for the ecdysone-regulated processes of molting and puparium formation. Acts downstream from ecdysone biosynthesis and release to control the expression of specific ecdysone-regulated genes such as Eip74EF (E74).

Protein Sequence
(Fasta)

MNSQVMYHNV PTPPGNVSLA AAAPDGGLLY AGIRCINYIS APPANGEQPQ VVTMSTRINI 60
LALDVSPMWG LGNGGPTKPF AIVGDDLSVQ VWDCALGEAV IGHKAHQHQH EARDVRVVHH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAACACTAAC AGCTTTACAG AAGTTTTTTC CCCGAACGAC GCCAACTGTT AGCGGGAAAT 60
ATTCCTTCAT CCTGCAGATG CCAAGTCCTT ATTGTTCGCC ATGAACTCGC AGGTGATGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1

Pfam

PF12894--ANAPC4_WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0071254--C:cytoplasmic U snRNP body
GO:0005634--C:nucleus
GO:0032797--C:SMN complex
GO:0008344--P:adult locomotory behavior
GO:0060429--P:epithelium development
GO:0007629--P:flight behavior
GO:0007293--P:germarium-derived egg chamber formation
GO:0007591--P:molting cycle, chitin-based cuticle
GO:0007275--P:multicellular organism development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0035075--P:response to ecdysone
GO:0000387--P:spliceosomal snRNP assembly
GO:0006351--P:transcription, DNA-templated

KEGG

dme:Dmel_CG30149

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010753	Astyanax mexicanus	35.35	1.00e-11	65.50
IUUC-Cho-024860	Choloepus hoffmanni	31.25	9.00e-11	62.80
IUUC-Cin-025778	Ciona intestinalis	24.79	3.00e-12	67.00
IUUC-Dor-030885	Dipodomys ordii	29.07	1.00e-10	62.00
IUUC-Ete-032918	Echinops telfairi	32.14	2.00e-10	61.60
IUUC-Lch-050489	Latimeria chalumnae	29.17	6.00e-11	62.80
IUUC-Loc-052259	Lepisosteus oculatus	33.81	1.00e-11	65.50
IUUC-Meu-056245	Macropus eugenii	31.25	5.00e-11	63.20
IUUC-Oan-073056	Ornithorhynchus anatinus	32.14	7.00e-13	69.30
IUUC-Pfo-096348	Poecilia formosa	30.25	3.00e-11	64.30
IUUC-Tru-118491	Takifugu rubripes	31.93	2.00e-12	68.20
IUUC-Tsy-119629	Tarsius syrichta	31.25	3.00e-10	60.80
IUUC-Tni-120240	Tetraodon nigroviridis	30.25	1.00e-11	65.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence