• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063227
Ensembl Protein ID ENSMUSP00000038761.10
UniProt Accession Q8CFH6; SIK2_MOUSE
Genbank Protein ID BAC53845.1
Protein Name Serine/threonine-protein kinase SIK2; Salt-inducible kinase 2; Serine/threonine-protein kinase SNF1-like kinase 2
Genbank Nucleotide ID AB067780
Gene Name Sik2; Snf1lk2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000037112.16 ENSMUST00000176824.7 ENSMUSP00000134936.1
ENSMUSG00000037112.16 ENSMUST00000176663.7 ENSMUSP00000135376.1
ENSMUSG00000037112.16 ENSMUST00000041375.10 ENSMUSP00000038761.10
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 24561619
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.004 18.4 296 333
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLl 39
    ++e++l+ + + G+d+++ ++ L++ ++n aA+++Ll
   Q: 296 FNEQVLRLMHSLGIDQQKTVESLQNKSYNHFAAIYFLL 333
    68999********************************8 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Protein Sequence
(Fasta)
MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60
LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063227|UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGTCGGCT CACGTCAGCG CCGGCGCGCG CCTGGCTGGG CCCTGTGGGG CGGGAGGGAA 60
GCAGCGCCGG AGCGAGAGCC GCGGCCGTCG CCCAGAGCCC AGGCGCGCCG CCCGACGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063227|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR017090--Ser/Thr_kinase_SIK1/2
IPR034672--SIK
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0046626--P:regulation of insulin receptor signaling pathway

KEGG mmu:235344
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001538 Ailuropoda melanoleuca 89.74 0.00e+00 1146.00
IUUC-Cin-025762 Ciona intestinalis 62.57 2.00e-133 469.00
IUUC-Dme-031957 Drosophila melanogaster 69.39 3.00e-138 486.00
IUUC-Gac-041875 Gasterosteus aculeatus 70.77 0.00e+00 975.00
IUUC-Loc-051827 Lepisosteus oculatus 68.40 0.00e+00 966.00
IUUC-Pfo-096944 Poecilia formosa 71.54 0.00e+00 1027.00
IUUC-Pca-100848 Procavia capensis 91.87 2.00e-174 606.00
IUUC-Ssc-116288 Sus scrofa 92.59 2.00e-153 535.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved