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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106462
Ensembl Protein ID YDR080W
UniProt Accession P38959; D6VS67; P87334; Q12011; VPS41_YEAST
Genbank Protein ID BAA19071.1; CAA57607.1; CAA98899.1; CAA86802.1; DAA11927.1
Protein Name Vacuolar protein sorting-associated protein 41; Vacuolar morphogenesis protein 2
Genbank Nucleotide ID AB000223; X82086; Z74376; Z46796; BK006938
Gene Name VPS41; FET2; VAM2; YDR080W; D446; YD8554.13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDR080W YDR080W YDR080W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 24.79 2.00e-56 219.00 IUUC-Hsa-047030
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Required for vacuolar assembly and vacuolar traffic. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
 Required for vacuolar assembly and vacuolar traffic. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
Protein Sequence
(Fasta)
MTTDNHQNDS VLDQQSGERT IDESNSISDE NNVDNKREDV NVTSPTKSVS CISQAENGVA 60
SRTDESTITG SATDAETGDD DDDDDDDDDE DEDDEDEPPL LKYTRISQLP KNFFQRDSIS 120
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Protein Fasta Sequence


>IUUC-Sce-106462|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGACTACAG ATAATCATCA GAATGATTCT GTTTTGGATC AACAATCAGG CGAACGAACA 60
ATTGATGAGA GTAATTCCAT CTCTGACGAG AATAATGTTG ATAATAAGAG GGAAGACGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106462|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat
Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR011990--TPR-like_helical_dom
IPR016902--VPS41
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50236--CHCR
Pfam

PF00637--Clathrin
SMART

SM00299--CLH
SM00320--WD40
Gene Ontology

GO:0033263--C:CORVET complex
GO:0000329--C:fungal-type vacuole membrane
GO:0030897--C:HOPS complex
GO:0005770--C:late endosome
GO:0017137--F:Rab GTPase binding
GO:0032258--P:CVT pathway
GO:0016236--P:macroautophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0015031--P:protein transport
GO:0035542--P:regulation of SNARE complex assembly
GO:0032889--P:regulation of vacuole fusion, non-autophagic
GO:0006624--P:vacuolar protein processing
GO:0042144--P:vacuole fusion, non-autophagic
GO:0007033--P:vacuole organization
GO:0099022--P:vesicle tethering
GO:0016192--P:vesicle-mediated transport
KEGG sce:YDR080W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000207 Aegilops tauschii 24.20 4.00e-44 171.00
IUUC-Aml-001435 Ailuropoda melanoleuca 24.50 3.00e-62 231.00
IUUC-Atr-002975 Amborella trichopoda 23.67 7.00e-56 210.00
IUUC-Apl-003254 Anas platyrhynchos 24.72 9.00e-61 226.00
IUUC-Aca-005067 Anolis carolinensis 24.50 2.00e-57 215.00
IUUC-Aly-005839 Arabidopsis lyrata 23.74 5.00e-53 201.00
IUUC-Ath-006625 Arabidopsis thaliana 23.90 9.00e-53 200.00
IUUC-Ago-007960 Ashbya gossypii 43.70 0.00e+00 741.00
IUUC-Acl-008174 Aspergillus clavatus 25.06 1.00e-33 136.00
IUUC-Afl-008524 Aspergillus flavus 23.00 2.00e-31 130.00
IUUC-Afu-009054 Aspergillus fumigatus 23.39 2.00e-36 146.00
IUUC-Ani-009250 Aspergillus nidulans 26.35 2.00e-31 129.00
IUUC-Ang-009665 Aspergillus niger 21.71 1.00e-31 130.00
IUUC-Aor-010230 Aspergillus oryzae 23.00 1.00e-31 130.00
IUUC-Ate-010464 Aspergillus terreus 24.37 2.00e-32 132.00
IUUC-Ame-011311 Astyanax mexicanus 24.85 4.00e-47 181.00
IUUC-Bgr-012099 Blumeria graminis 23.84 2.00e-31 129.00
IUUC-Bta-013327 Bos taurus 24.05 3.00e-60 224.00
IUUC-Bci-013660 Botrytis cinerea 22.09 1.00e-25 110.00
IUUC-Bdi-014641 Brachypodium distachyon 23.12 6.00e-50 190.00
IUUC-Bol-015685 Brassica oleracea 24.15 2.00e-57 215.00
IUUC-Bra-016918 Brassica rapa 23.82 1.00e-54 206.00
IUUC-Cel-018385 Caenorhabditis elegans 24.09 7.00e-25 107.00
IUUC-Cja-018994 Callithrix jacchus 24.44 2.00e-61 228.00
IUUC-Cfa-020405 Canis familiaris 24.61 7.00e-62 230.00
IUUC-Cpo-022163 Cavia porcellus 24.33 8.00e-61 226.00
IUUC-Cre-022626 Chlamydomonas reinhardtii 31.15 3.00e-12 65.50
IUUC-Csa-023134 Chlorocebus sabaeus 24.39 7.00e-62 230.00
IUUC-Cho-024913 Choloepus hoffmanni 22.44 1.00e-30 126.00
IUUC-Cin-025239 Ciona intestinalis 22.76 6.00e-42 164.00
IUUC-Cgl-026706 Colletotrichum gloeosporioides 22.24 2.00e-29 123.00
IUUC-Cne-026799 Cryptococcus neoformans 24.75 1.00e-79 289.00
IUUC-Cme-027200 Cyanidioschyzon merolae 26.88 4.00e-03 35.00
IUUC-Dre-028115 Danio rerio 25.45 9.00e-63 233.00
IUUC-Dor-030947 Dipodomys ordii 23.60 6.00e-56 210.00
IUUC-Dse-031544 Dothistroma septosporum 22.18 2.00e-30 126.00
IUUC-Dme-031830 Drosophila melanogaster 21.60 3.00e-34 138.00
IUUC-Ete-033051 Echinops telfairi 31.69 2.00e-21 95.90
IUUC-Eca-033501 Equus caballus 24.33 3.00e-61 228.00
IUUC-Eeu-034555 Erinaceus europaeus 21.70 3.00e-23 101.00
IUUC-Fca-035809 Felis catus 24.55 4.00e-60 224.00
IUUC-Fal-037056 Ficedula albicollis 24.72 2.00e-60 225.00
IUUC-Fox-037949 Fusarium oxysporum 21.58 6.00e-30 124.00
IUUC-Fso-038282 Fusarium solani 21.69 1.00e-27 117.00
IUUC-Gmo-038540 Gadus morhua 25.67 6.00e-60 223.00
IUUC-Ggr-039733 Gaeumannomyces graminis 24.79 6.00e-31 128.00
IUUC-Gga-040446 Gallus gallus 24.72 3.00e-60 224.00
IUUC-Gac-041462 Gasterosteus aculeatus 25.86 1.00e-60 226.00
IUUC-Gma-043148 Glycine max 23.46 1.00e-56 213.00
IUUC-Hsa-047030 Homo sapiens 24.50 1.00e-61 229.00
IUUC-Hvu-047693 Hordeum vulgare 23.91 1.00e-47 183.00
IUUC-Itr-048318 Ictidomys tridecemlineatus 24.16 1.00e-60 226.00
IUUC-Kpa-049224 Komagataella pastoris 31.63 1.00e-130 458.00
IUUC-Lch-049444 Latimeria chalumnae 23.82 3.00e-58 218.00
IUUC-Lpe-050942 Leersia perrieri 23.33 6.00e-44 171.00
IUUC-Loc-052260 Lepisosteus oculatus 25.00 3.00e-63 234.00
IUUC-Lma-053173 Leptosphaeria maculans 22.46 5.00e-26 112.00
IUUC-Laf-054185 Loxodonta africana 24.44 2.00e-61 228.00
IUUC-Mcc-054816 Macaca mulatta 24.28 1.00e-61 229.00
IUUC-Meu-056483 Macropus eugenii 32.34 4.00e-26 111.00
IUUC-Mor-056979 Magnaporthe oryzae 22.50 4.00e-33 135.00
IUUC-Mpo-057312 Magnaporthe poae 24.53 1.00e-30 127.00
IUUC-Mtr-057630 Medicago truncatula 22.76 7.00e-55 207.00
IUUC-Mla-058930 Melampsora laricipopulina 27.32 3.00e-21 92.80
IUUC-Mga-059942 Meleagris gallopavo 24.69 8.00e-60 223.00
IUUC-Mvi-060386 Microbotryum violaceum 25.71 1.00e-72 266.00
IUUC-Mmr-060640 Microcebus murinus 24.55 4.00e-61 227.00
IUUC-Mdo-062934 Monodelphis domestica 22.49 1.00e-34 139.00
IUUC-Mmu-063488 Mus musculus 24.33 2.00e-60 225.00
IUUC-Mac-064975 Musa acuminata 22.57 4.00e-49 187.00
IUUC-Mpu-065777 Mustela putorius furo 24.67 1.00e-61 229.00
IUUC-Mlu-068052 Myotis lucifugus 24.61 6.00e-63 233.00
IUUC-Nfi-068436 Neosartorya fischeri 22.32 1.00e-34 140.00
IUUC-Ncr-068840 Neurospora crassa 22.28 1.00e-31 130.00
IUUC-Nle-070063 Nomascus leucogenys 24.39 9.00e-60 223.00
IUUC-Opr-070385 Ochotona princeps 23.00 2.00e-24 105.00
IUUC-Ont-072367 Oreochromis niloticus 25.72 2.00e-61 228.00
IUUC-Oan-073085 Ornithorhynchus anatinus 23.87 3.00e-55 207.00
IUUC-Ocu-074672 Oryctolagus cuniculus 24.39 1.00e-61 229.00
IUUC-Oba-075574 Oryza barthii 24.37 7.00e-55 207.00
IUUC-Obr-076203 Oryza brachyantha 24.61 3.00e-53 201.00
IUUC-Ogl-077909 Oryza glaberrima 24.37 7.00e-55 207.00
IUUC-Ogu-078053 Oryza glumaepatula 24.26 2.00e-54 206.00
IUUC-Oin-079700 Oryza indica 24.49 2.00e-55 208.00
IUUC-Olo-080707 Oryza longistaminata 24.24 2.00e-57 215.00
IUUC-Oni-082754 Oryza nivara 24.47 8.00e-55 206.00
IUUC-Opu-083854 Oryza punctata 24.73 3.00e-55 208.00
IUUC-Oru-085071 Oryza rufipogon 24.31 9.00e-55 206.00
IUUC-Osa-085370 Oryza sativa 24.37 7.00e-55 207.00
IUUC-Ola-086362 Oryzias latipes 24.55 2.00e-57 215.00
IUUC-Oga-088078 Otolemur garnettii 24.61 8.00e-58 216.00
IUUC-Oar-089679 Ovis aries 23.94 5.00e-60 223.00
IUUC-Ptr-091680 Pan troglodytes 24.50 1.00e-61 229.00
IUUC-Pan-092816 Papio anubis 26.20 8.00e-42 162.00
IUUC-Psi-093890 Pelodiscus sinensis 24.05 1.00e-58 219.00
IUUC-Pma-094654 Petromyzon marinus 23.27 6.00e-51 193.00
IUUC-Pno-095071 Phaeosphaeria nodorum 23.19 8.00e-34 137.00
IUUC-Ppa-095198 Physcomitrella patens 21.92 4.00e-24 105.00
IUUC-Pfo-097465 Poecilia formosa 24.44 1.00e-54 206.00
IUUC-Pab-098686 Pongo abelii 24.50 2.00e-61 228.00
IUUC-Pop-100066 Populus trichocarpa 22.12 6.00e-57 213.00
IUUC-Pca-100990 Procavia capensis 23.92 1.00e-49 189.00
IUUC-Ppe-101500 Prunus persica 22.83 4.00e-57 214.00
IUUC-Pva-102809 Pteropus vampyrus 24.39 3.00e-61 228.00
IUUC-Pgr-103404 Puccinia graminis 24.97 2.00e-72 265.00
IUUC-Ptt-103952 Puccinia triticina 24.63 3.00e-67 248.00
IUUC-Pte-104216 Pyrenophora teres 22.24 3.00e-31 129.00
IUUC-Rno-105949 Rattus norvegicus 24.68 1.00e-59 223.00
IUUC-Sha-106689 Sarcophilus harrisii 25.11 7.00e-61 226.00
IUUC-Sja-107696 Schizosaccharomyces japonicus 22.89 1.00e-45 176.00
IUUC-Spo-108173 Schizosaccharomyces pombe 25.40 4.00e-52 197.00
IUUC-Smo-109505 Selaginella moellendorffii 24.54 8.00e-51 193.00
IUUC-Sit-110176 Setaria italica 23.60 3.00e-57 215.00
IUUC-Sly-111840 Solanum lycopersicum 22.81 4.00e-60 224.00
IUUC-Sar-113073 Sorex araneus 25.29 2.00e-40 159.00
IUUC-Sbi-114139 Sorghum bicolor 23.89 4.00e-54 204.00
IUUC-Sre-115158 Sporisorium reilianum 25.08 1.00e-74 273.00
IUUC-Ssc-115894 Sus scrofa 24.27 4.00e-62 231.00
IUUC-Tgu-117481 Taeniopygia guttata 24.72 8.00e-61 226.00
IUUC-Tru-118468 Takifugu rubripes 25.17 7.00e-60 223.00
IUUC-Tni-120478 Tetraodon nigroviridis 25.72 8.00e-59 219.00
IUUC-Tca-121780 Theobroma cacao 21.67 2.00e-55 209.00
IUUC-Tre-121900 Trichoderma reesei 25.77 6.00e-29 121.00
IUUC-Tvi-122343 Trichoderma virens 25.32 2.00e-28 119.00
IUUC-Tae-123578 Triticum aestivum 24.20 3.00e-49 188.00
IUUC-Tur-126430 Triticum urartu 24.33 2.00e-46 179.00
IUUC-Tme-127007 Tuber melanosporum 29.74 3.00e-24 105.00
IUUC-Tbe-128073 Tupaia belangeri 23.85 9.00e-49 186.00
IUUC-Ttr-128879 Tursiops truncatus 24.86 1.00e-60 226.00
IUUC-Uma-129356 Ustilago maydis 25.08 8.00e-72 263.00
IUUC-Vda-129676 Verticillium dahliae 23.47 6.00e-32 131.00
IUUC-Vvi-131744 Vitis vinifera 21.50 2.00e-51 195.00
IUUC-Xtr-132093 Xenopus tropicalis 25.43 1.00e-59 223.00
IUUC-Xma-133199 Xiphophorus maculatus 24.89 9.00e-57 213.00
IUUC-Yli-134385 Yarrowia lipolytica 32.09 6.00e-120 423.00
IUUC-Zma-135567 Zea mays 23.92 4.00e-52 197.00
Created Date 25-Jun-2017

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