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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063291
UUCD1 version UUC-MuM-00975
Ensembl Protein ID ENSMUSP00000003310.5
UniProt Accession Q9ERU9; E9QM01; Q61992; Q8C9K9; RBP2_MOUSE
Genbank Protein ID AAG17403.1; BAC31101.1; CAA60778.1
Protein Name E3 SUMO-protein ligase RanBP2; Ran-binding protein 2
Genbank Nucleotide ID AF279458; AC158593; X87337
Gene Name Ranbp2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000003226.6 ENSMUST00000003310.5 ENSMUSP00000003310.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/NZF 3.60e-30 104.3 1618 1646
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           e++W C +C  +Ne++++kC++C+  +++
   Q: 1618 EGEWECAVCSVQNESSSLKCVACEASKPT 1646
           789**********************9985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle.
 E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle.
Protein Sequence
(Fasta)
MRRSKADVER YIASVQGSAP SPREKSMKGF YFAKLYYEAK EYDLAKKYIS TYINVQERDP 60
KAHRFLGLLY EVEENIDKAV ECYKRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063291|UBD,NZF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGCCCTGTG CCCATCCGTT CGCGACGGAG CTGCGTCACC GGTGTTCGGC GCTCACCTCC 60
TGGAGCCCGC AGTCGCTGTA GGCCCCAGGG CTGGTCTGCC GCTCCTGGGG AGCCTGGTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063291|UBD,NZF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0802--TPR repeat
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR029000--Cyclophilin-like_dom
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR022011--IR1-M
IPR011993--PH_dom-like
IPR000156--Ran_bind_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR001876--Znf_RanBP2
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS50196--RANBD1
PS50005--TPR
PS50293--TPR_REGION
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF12185--IR1-M
PF00160--Pro_isomerase
PF00638--Ran_BP1
PF00641--zf-RanBP
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00160--RanBD
SM00028--TPR
SM00547--ZnF_RBZ
Gene Ontology

GO:0005642--C:annulate lamellae
GO:0005813--C:centrosome
GO:1990723--C:cytoplasmic periphery of the nuclear pore complex
GO:0005739--C:mitochondrion
GO:0005635--C:nuclear envelope
GO:0042405--C:nuclear inclusion body
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044614--C:nuclear pore cytoplasmic filaments
GO:0044615--C:nuclear pore nuclear basket
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0008536--F:Ran GTPase binding
GO:0003723--F:RNA binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0051028--P:mRNA transport
GO:0033133--P:positive regulation of glucokinase activity
GO:0043547--P:positive regulation of GTPase activity
GO:0046604--P:positive regulation of mitotic centrosome separation
GO:0006457--P:protein folding
GO:0006606--P:protein import into nucleus
GO:0016925--P:protein sumoylation
GO:0090526--P:regulation of gluconeogenesis involved in cellular glucose homeostasis
GO:0001975--P:response to amphetamine
GO:0006405--P:RNA export from nucleus
GO:0007051--P:spindle organization
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:19386
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002141 Ailuropoda melanoleuca 83.31 0.00e+00 2783.00
IUUC-Apl-004213 Anas platyrhynchos 64.75 0.00e+00 1042.00
IUUC-Aca-005244 Anolis carolinensis 64.26 0.00e+00 3509.00
IUUC-Ame-011486 Astyanax mexicanus 53.82 0.00e+00 1272.00
IUUC-Bta-012952 Bos taurus 81.22 0.00e+00 4788.00
IUUC-Cja-019112 Callithrix jacchus 85.06 0.00e+00 2787.00
IUUC-Cfa-020158 Canis familiaris 81.39 0.00e+00 2741.00
IUUC-Cpo-022292 Cavia porcellus 81.91 0.00e+00 2519.00
IUUC-Csa-023696 Chlorocebus sabaeus 85.21 0.00e+00 2721.00
IUUC-Cho-024560 Choloepus hoffmanni 76.83 0.00e+00 1035.00
IUUC-Dre-027540 Danio rerio 47.26 0.00e+00 1347.00
IUUC-Dno-029177 Dasypus novemcinctus 78.65 0.00e+00 4600.00
IUUC-Dor-030161 Dipodomys ordii 80.80 0.00e+00 1471.00
IUUC-Dme-032206 Drosophila melanogaster 33.08 5.00e-38 154.00
IUUC-Ete-032679 Echinops telfairi 76.71 0.00e+00 2055.00
IUUC-Eca-034415 Equus caballus 84.43 0.00e+00 2739.00
IUUC-Eeu-035195 Erinaceus europaeus 72.33 0.00e+00 2640.00
IUUC-Fca-036339 Felis catus 82.31 0.00e+00 4784.00
IUUC-Fal-036665 Ficedula albicollis 63.12 0.00e+00 3589.00
IUUC-Gmo-038469 Gadus morhua 44.94 0.00e+00 1273.00
IUUC-Gga-041154 Gallus gallus 60.91 0.00e+00 3112.00
IUUC-Gac-042057 Gasterosteus aculeatus 49.78 0.00e+00 2747.00
IUUC-Hsa-046168 Homo sapiens 84.49 0.00e+00 2779.00
IUUC-Itr-049075 Ictidomys tridecemlineatus 85.40 0.00e+00 4498.00
IUUC-Lch-050060 Latimeria chalumnae 57.88 0.00e+00 1790.00
IUUC-Loc-052650 Lepisosteus oculatus 53.12 0.00e+00 2922.00
IUUC-Laf-053667 Loxodonta africana 83.80 0.00e+00 4977.00
IUUC-Mcc-055115 Macaca mulatta 85.39 0.00e+00 2778.00
IUUC-Mga-059419 Meleagris gallopavo 62.53 0.00e+00 3591.00
IUUC-Mmr-061001 Microcebus murinus 83.10 0.00e+00 2875.00
IUUC-Mdo-061922 Monodelphis domestica 69.84 0.00e+00 2503.00
IUUC-Mpu-066011 Mustela putorius furo 80.00 0.00e+00 2474.00
IUUC-Mlu-067422 Myotis lucifugus 81.60 0.00e+00 2672.00
IUUC-Nle-069190 Nomascus leucogenys 83.03 0.00e+00 2622.00
IUUC-Opr-070420 Ochotona princeps 74.57 0.00e+00 2757.00
IUUC-Ont-071362 Oreochromis niloticus 51.94 0.00e+00 2878.00
IUUC-Oan-072832 Ornithorhynchus anatinus 68.44 0.00e+00 2133.00
IUUC-Ocu-073902 Oryctolagus cuniculus 80.49 0.00e+00 4769.00
IUUC-Ola-087304 Oryzias latipes 48.74 0.00e+00 2615.00
IUUC-Oga-088196 Otolemur garnettii 85.65 0.00e+00 5133.00
IUUC-Oar-089627 Ovis aries 80.71 0.00e+00 4734.00
IUUC-Ptr-091152 Pan troglodytes 84.31 0.00e+00 2773.00
IUUC-Pan-091914 Papio anubis 85.39 0.00e+00 2778.00
IUUC-Psi-093994 Pelodiscus sinensis 69.97 0.00e+00 4041.00
IUUC-Pma-094629 Petromyzon marinus 40.10 0.00e+00 830.00
IUUC-Pfo-096897 Poecilia formosa 45.94 0.00e+00 1237.00
IUUC-Pab-097566 Pongo abelii 80.02 0.00e+00 2462.00
IUUC-Pca-100141 Procavia capensis 77.72 0.00e+00 2624.00
IUUC-Pva-102323 Pteropus vampyrus 81.12 0.00e+00 1879.00
IUUC-Rno-105473 Rattus norvegicus 90.13 0.00e+00 5437.00
IUUC-Sha-106537 Sarcophilus harrisii 75.06 0.00e+00 4414.00
IUUC-Sar-113031 Sorex araneus 86.45 0.00e+00 1235.00
IUUC-Ssc-115622 Sus scrofa 75.93 0.00e+00 2392.00
IUUC-Tgu-116781 Taeniopygia guttata 63.33 0.00e+00 1943.00
IUUC-Tru-118684 Takifugu rubripes 42.91 0.00e+00 1028.00
IUUC-Tsy-119490 Tarsius syrichta 72.33 0.00e+00 1731.00
IUUC-Tbe-127349 Tupaia belangeri 85.52 0.00e+00 1769.00
IUUC-Ttr-128883 Tursiops truncatus 78.36 0.00e+00 2252.00
IUUC-Vpa-130224 Vicugna pacos 78.29 0.00e+00 2456.00
IUUC-Xtr-132557 Xenopus tropicalis 57.19 0.00e+00 3008.00
Created Date 25-Jun-2017

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