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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046043
UUCD1 version UUC-HoS-01125
Ensembl Protein ID ENSP00000258399.3
UniProt Accession Q86T82; A2RUQ8; B7ZM38; B7ZM41; E9PHL3; Q2KHT2; Q53S10; Q7Z3A5; Q9HCH8; UBP37_HUMAN
Genbank Protein ID CAD89955.1; CAD97970.1; AAY14887.1; EAW70621.1; AAI12902.1; AAI33008.1; AAI33010.1; AAI44250.1; AAI44253.1; BAB13420.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37
Genbank Nucleotide ID AL832645; BX538024; AC012510; CH471063; BC112901; BC133007; BC133009; BC144249; BC144252; AB046814
Gene Name USP37; KIAA1594
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135913.10 ENST00000258399.7 ENSP00000258399.3
ENSG00000135913.10 ENST00000415516.5 ENSP00000400902.1
ENSG00000135913.10 ENST00000338465.5 ENSP00000345043.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 14715245
UBD/Alpha-Helix/UIM UIM 11406394
Classification
Family E-value Score Start End
DUB/USP 2.60e-88 298.1 341 950
UBD/Alpha-Helix/UIM 0.0013 20.2 807 824
UBD/Alpha-Helix/UIM 0.00036 12.7 828 846
Active Site
Position(s) Description Evidence
350 Nucleophile {ECO:0000269|PubMed:27296872}
906 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqq 90
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy+q+
   Q: 341  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGYMQN 427
           69*****************************...*****9..679999999999999776567***************************** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet 182
           Da+Efl+++ldql+e+++k  nk++++e  + +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++p++++ 
   Q: 428  DAHEFLSQCLDQLKEDMEK-LNKTWKTEPVSGEENSPDI---SATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKP 515
           *****************55.9999999999999999999...7999*****************************************99988 PP
   S: 183  kke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...... 267
            ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++ct+      
   Q: 516  LPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTEntkppf 602
           6545***************9....*********9.89999**********************************************99**** PP
   S: 268  ............................................................................................ 267
                                                                                                       
   Q: 603  tlgwsahmaisrplkasqmvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrlcemlgneqqqedlekdsklcpiepdkse 694
           *************9999999999999999999999999999999999999999999999999999999999888888888888888888888 PP
   S: 268  ............................................................................................ 267
                                                                                                       
   Q: 695  lensgfdrmseeellaavleiskrdaspslshedddkptsspdtgfaeddiqempenpdtmetekpktiteldpasfteitkdcdenkenkt 786
           88888888888888888888888888888887777777777777777777777777777777777777777776666666666665555555 PP
   S: 268  peekqke..................................................................................... 274
           p     e                                                                                     
   Q: 787  P-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfvdalgsdedsgnedvfdmeyteaea 873
           0.....05555555555555555555556666666666666677777777777777777777888888888888888888888888888888 PP
   S: 275  ............kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
                       +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v++++++++Y++fY++
   Q: 874  eelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMH 950
           888899999999****************************99999******************************98 PP
   

   UBD/Alpha-Helix/UIM
   S: 2    EdeeLqlAlalSlqEeee 19
           E++eLq+Ala+SlqE+e 
   Q: 807  EEQELQQALAQSLQEQEA 824
           9**************985 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +Ed++L +A +lSlqE ++
   Q: 828  KEDDDLKRATELSLQEFNN 846
           69**************876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
 Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
Protein Sequence
(Fasta)
MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLPAA MKPSQGSGSF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046043|DUB,USP;UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGCGTGCGT GTTTGCGTGT GGTCACAGTT CCCGCCATCA GCCGCTCTCC CTGACTAGGG 60
GTAGCTAGCG GCCTCCCTCC TTTGGGTTCG GTATCCCTAC TTCCATTACC CTCGGCTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046043|DUB,USP;UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM
SMART

SM00726--UIM
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0019901--F:protein kinase binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0051301--P:cell division
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:57695
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001400 Ailuropoda melanoleuca 95.52 0.00e+00 1743.00
IUUC-Apl-004033 Anas platyrhynchos 77.47 0.00e+00 1435.00
IUUC-Aca-005370 Anolis carolinensis 69.73 0.00e+00 1312.00
IUUC-Ame-011884 Astyanax mexicanus 57.43 0.00e+00 985.00
IUUC-Bta-012725 Bos taurus 94.69 0.00e+00 1711.00
IUUC-Cja-019939 Callithrix jacchus 97.04 0.00e+00 1715.00
IUUC-Cfa-020835 Canis familiaris 95.72 0.00e+00 1798.00
IUUC-Cpo-022067 Cavia porcellus 93.43 0.00e+00 1559.00
IUUC-Cre-022867 Chlamydomonas reinhardtii 29.63 2.00e-24 107.00
IUUC-Csa-023085 Chlorocebus sabaeus 98.88 0.00e+00 1820.00
IUUC-Cho-024390 Choloepus hoffmanni 87.11 2.00e-165 576.00
IUUC-Cin-025496 Ciona intestinalis 37.25 1.00e-42 168.00
IUUC-Csv-025812 Ciona savignyi 36.22 7.00e-42 165.00
IUUC-Dre-028255 Danio rerio 57.26 0.00e+00 946.00
IUUC-Dno-028986 Dasypus novemcinctus 94.40 0.00e+00 1697.00
IUUC-Dor-031062 Dipodomys ordii 80.00 0.00e+00 887.00
IUUC-Ete-032359 Echinops telfairi 82.76 0.00e+00 817.00
IUUC-Eca-033964 Equus caballus 94.29 0.00e+00 1732.00
IUUC-Eeu-034492 Erinaceus europaeus 86.21 0.00e+00 824.00
IUUC-Fca-036359 Felis catus 94.90 0.00e+00 1734.00
IUUC-Fal-037640 Ficedula albicollis 77.58 0.00e+00 1405.00
IUUC-Gmo-039600 Gadus morhua 54.51 0.00e+00 933.00
IUUC-Gga-040126 Gallus gallus 77.37 0.00e+00 1368.00
IUUC-Gac-041557 Gasterosteus aculeatus 53.91 0.00e+00 914.00
IUUC-Ggo-045571 Gorilla gorilla 95.69 0.00e+00 1609.00
IUUC-Itr-048207 Ictidomys tridecemlineatus 94.79 0.00e+00 1700.00
IUUC-Lch-050357 Latimeria chalumnae 64.16 0.00e+00 1036.00
IUUC-Loc-052849 Lepisosteus oculatus 61.37 0.00e+00 1004.00
IUUC-Laf-054570 Loxodonta africana 92.36 0.00e+00 1643.00
IUUC-Mcc-054989 Macaca mulatta 98.77 0.00e+00 1684.00
IUUC-Meu-056273 Macropus eugenii 64.73 4.00e-171 595.00
IUUC-Mga-059814 Meleagris gallopavo 75.76 0.00e+00 1375.00
IUUC-Mmr-061726 Microcebus murinus 95.10 0.00e+00 1746.00
IUUC-Mdo-062974 Monodelphis domestica 85.22 0.00e+00 1572.00
IUUC-Mmu-064069 Mus musculus 90.41 0.00e+00 1619.00
IUUC-Mpu-066008 Mustela putorius furo 94.90 0.00e+00 1703.00
IUUC-Nle-069259 Nomascus leucogenys 99.29 0.00e+00 1785.00
IUUC-Opr-070882 Ochotona princeps 78.42 1.00e-140 494.00
IUUC-Ont-072441 Oreochromis niloticus 54.65 0.00e+00 927.00
IUUC-Oan-073151 Ornithorhynchus anatinus 76.26 7.00e-119 420.00
IUUC-Ocu-074879 Oryctolagus cuniculus 93.57 0.00e+00 1714.00
IUUC-Ola-087007 Oryzias latipes 53.35 0.00e+00 885.00
IUUC-Oga-088385 Otolemur garnettii 93.81 0.00e+00 1729.00
IUUC-Oar-090305 Ovis aries 92.76 0.00e+00 1736.00
IUUC-Ptr-091299 Pan troglodytes 99.80 0.00e+00 1808.00
IUUC-Pan-091996 Papio anubis 98.85 0.00e+00 1765.00
IUUC-Psi-093176 Pelodiscus sinensis 77.82 0.00e+00 1435.00
IUUC-Pma-094331 Petromyzon marinus 48.62 0.00e+00 768.00
IUUC-Ppa-095732 Physcomitrella patens 31.09 9.00e-25 108.00
IUUC-Pfo-096503 Poecilia formosa 56.29 0.00e+00 928.00
IUUC-Pab-098543 Pongo abelii 98.01 0.00e+00 960.00
IUUC-Pca-101099 Procavia capensis 87.20 0.00e+00 1298.00
IUUC-Pva-103163 Pteropus vampyrus 88.16 0.00e+00 1603.00
IUUC-Rno-105766 Rattus norvegicus 91.43 0.00e+00 1636.00
IUUC-Sha-106610 Sarcophilus harrisii 81.37 0.00e+00 1472.00
IUUC-Sar-113256 Sorex araneus 89.22 4.00e-110 392.00
IUUC-Ssc-116353 Sus scrofa 94.60 0.00e+00 1689.00
IUUC-Tgu-116971 Taeniopygia guttata 77.37 0.00e+00 1372.00
IUUC-Tru-117932 Takifugu rubripes 45.12 0.00e+00 664.00
IUUC-Tsy-119185 Tarsius syrichta 90.48 0.00e+00 1129.00
IUUC-Tni-119842 Tetraodon nigroviridis 60.13 1.00e-110 393.00
IUUC-Tbe-127281 Tupaia belangeri 83.68 0.00e+00 656.00
IUUC-Ttr-128177 Tursiops truncatus 94.81 0.00e+00 1340.00
IUUC-Vpa-130031 Vicugna pacos 94.90 0.00e+00 1770.00
IUUC-Xtr-132949 Xenopus tropicalis 65.22 0.00e+00 1162.00
Created Date 25-Jun-2017

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