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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031905
UUCD1 version UUC-DrM-00007
Ensembl Protein ID FBpp0080391
UniProt Accession Q24044; Q24044_DROME
Genbank Protein ID AAA83150.1; AAF53523.1; ABK57089.1; ACL68690.1
Protein Name FI02843p; Fizzy; LD44795p
Genbank Nucleotide ID U22419; AE014134; BT029432; BT056243
Gene Name fzy; fzy-RA; CG4274; Dmel_CG4274
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0001086 FBtr0080833 FBpp0080391
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 19906849
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.50e-24 83.5 332 364
E3 adaptor/Cullin RING/APC_C/CDC20 1.30e-143 477.9 199 504
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gHt +v++l++ +d ++l+sG++D+ + vW+  
   Q: 332  GHTQEVCGLKWsTDfKYLASGGNDNLVNVWSAA 364
           8**********999****************965 PP
   

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 2    ekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltghsarv 99
           e++ldap++ +d+ylnL+dWs++n++avaLgs+vylw+a+tg++++l+++ee+d+  s+swi+eg++la+G+++g+ve++D+++ k++r+++ghsarv
   Q: 199  ERILDAPDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARV 296
           79************************************************************************************************ PP
   S: 100  gaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse......PlkkfkehkaavkaiawsPwq 191
           g+L+Wn+ ++ssGsrdg+i+h+dvr++e+klstl++h+qevCGlkw++d k+LasGGnDn v+vw+a+s        Pl+kf++h+aav+a+aw+Pwq
   Q: 297  GSLAWNSFLVSSGSRDGTIVHHDVRAREHKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGvgtatdPLHKFNDHQAAVRALAWCPWQ 394
           *******************************************************************9987778888********************* PP
   S: 192  kslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgeaivtaagDe 289
           +s LasGGGtaDrcikfwn+++g+l++++d++sqvcsll+s+++kel+s+hGfa+n++t+wkyp++ k+a+l+gh++Rvl++a+spdg+++++a++De
   Q: 395  PSTLASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADE 492
           ************************************************************************************************** PP
   S: 290  tlrfwklfdkkk 301
           tlr+w++f +++
   Q: 493  TLRLWNCFAPDP 504
           ********9876 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MSQFNFVSDL QNALIMDGET RGPAPRWKKK LEASLNGSVN TTRSVLSVSY NTSFSGVQAP 60
TKTPGKSSEG KTKKSNTTPS KTPGGGDRFI PNRAATNFEL AHFLVNKDSG DKSDEENDKA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031905|E3,CDC20;E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TACATTTCCA AATCGAACCG CCATTTGTGT TGCATCTCGA AATCTGGAAA AAATTCGATC 60
CAAGTGTTCT ATGAGCTTCT GTTTTTTAAT AATAATAAAT AAATAAATTC GATAATCAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031905|E3,CDC20;E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0000776--C:kinetochore
GO:0005819--C:spindle
GO:0061630--F:ubiquitin protein ligase activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0007144--P:female meiosis I
GO:0007147--P:female meiosis II
GO:0030718--P:germ-line stem cell population maintenance
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0060547--P:negative regulation of necrotic cell death
GO:0022008--P:neurogenesis
GO:0097150--P:neuronal stem cell population maintenance
GO:0006909--P:phagocytosis
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0030163--P:protein catabolic process
GO:0007096--P:regulation of exit from mitosis
GO:0030162--P:regulation of proteolysis
KEGG dme:Dmel_CG4274
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000974 Aegilops tauschii 47.48 5.00e-112 397.00
IUUC-Aml-001545 Ailuropoda melanoleuca 50.75 2.00e-139 488.00
IUUC-Atr-003103 Amborella trichopoda 45.37 8.00e-111 392.00
IUUC-Apl-003255 Anas platyrhynchos 52.09 2.00e-134 471.00
IUUC-Aca-004920 Anolis carolinensis 48.50 2.00e-130 458.00
IUUC-Aly-006012 Arabidopsis lyrata 46.98 1.00e-110 392.00
IUUC-Ath-006795 Arabidopsis thaliana 47.67 1.00e-110 392.00
IUUC-Bta-012625 Bos taurus 50.66 5.00e-138 483.00
IUUC-Bdi-014344 Brachypodium distachyon 45.38 1.00e-113 402.00
IUUC-Bol-015368 Brassica oleracea 47.66 1.00e-111 397.00
IUUC-Bra-016738 Brassica rapa 47.60 1.00e-111 396.00
IUUC-Cja-019132 Callithrix jacchus 50.28 4.00e-138 483.00
IUUC-Cfa-020780 Canis familiaris 50.85 8.00e-139 486.00
IUUC-Cpo-022223 Cavia porcellus 49.63 1.00e-126 445.00
IUUC-Cre-022701 Chlamydomonas reinhardtii 46.68 6.00e-111 393.00
IUUC-Csa-023666 Chlorocebus sabaeus 50.37 2.00e-138 484.00
IUUC-Cho-024920 Choloepus hoffmanni 42.54 1.00e-61 229.00
IUUC-Cin-025675 Ciona intestinalis 48.17 7.00e-126 443.00
IUUC-Csv-026019 Ciona savignyi 46.47 5.00e-119 420.00
IUUC-Cme-027234 Cyanidioschyzon merolae 46.87 9.00e-104 369.00
IUUC-Dre-028026 Danio rerio 47.45 8.00e-129 452.00
IUUC-Dno-028865 Dasypus novemcinctus 48.79 5.00e-135 473.00
IUUC-Dor-030958 Dipodomys ordii 49.63 4.00e-133 467.00
IUUC-Dse-031391 Dothistroma septosporum 37.63 7.00e-95 340.00
IUUC-Ete-032387 Echinops telfairi 46.63 2.00e-129 455.00
IUUC-Eca-033522 Equus caballus 44.30 5.00e-117 414.00
IUUC-Eeu-035059 Erinaceus europaeus 45.90 2.00e-111 395.00
IUUC-Fca-036346 Felis catus 49.58 2.00e-121 427.00
IUUC-Fal-037558 Ficedula albicollis 49.72 1.00e-135 475.00
IUUC-Gmo-039284 Gadus morhua 46.90 2.00e-125 441.00
IUUC-Gga-040790 Gallus gallus 50.19 5.00e-143 500.00
IUUC-Gac-041431 Gasterosteus aculeatus 45.39 5.00e-118 417.00
IUUC-Gma-043985 Glycine max 48.56 4.00e-107 380.00
IUUC-Ggo-045052 Gorilla gorilla 50.37 2.00e-138 484.00
IUUC-Hsa-046305 Homo sapiens 50.37 2.00e-138 484.00
IUUC-Hvu-047476 Hordeum vulgare 45.88 2.00e-111 395.00
IUUC-Itr-048461 Ictidomys tridecemlineatus 49.81 2.00e-127 448.00
IUUC-Lch-050174 Latimeria chalumnae 42.14 8.00e-106 376.00
IUUC-Lpe-050954 Leersia perrieri 45.45 9.00e-103 366.00
IUUC-Loc-052638 Lepisosteus oculatus 47.67 1.00e-124 439.00
IUUC-Lma-052998 Leptosphaeria maculans 36.12 2.00e-89 322.00
IUUC-Laf-053742 Loxodonta africana 50.19 3.00e-138 484.00
IUUC-Mcc-054948 Macaca mulatta 50.37 2.00e-138 484.00
IUUC-Mtr-057725 Medicago truncatula 47.42 2.00e-104 372.00
IUUC-Mga-060102 Meleagris gallopavo 51.04 1.00e-143 501.00
IUUC-Mmr-061615 Microcebus murinus 51.56 3.00e-138 484.00
IUUC-Mdo-061982 Monodelphis domestica 49.36 3.00e-113 403.00
IUUC-Mmu-063864 Mus musculus 50.75 2.00e-135 474.00
IUUC-Mac-064861 Musa acuminata 45.98 1.00e-110 392.00
IUUC-Mpu-066502 Mustela putorius furo 49.81 4.00e-138 484.00
IUUC-Mlu-067277 Myotis lucifugus 49.34 1.00e-133 469.00
IUUC-Nle-070149 Nomascus leucogenys 50.19 1.00e-136 479.00
IUUC-Opr-070778 Ochotona princeps 46.19 2.00e-85 308.00
IUUC-Ont-071660 Oreochromis niloticus 45.05 3.00e-117 414.00
IUUC-Oan-073677 Ornithorhynchus anatinus 56.99 1.00e-121 429.00
IUUC-Ocu-073797 Oryctolagus cuniculus 50.38 3.00e-138 484.00
IUUC-Oba-075514 Oryza barthii 46.53 5.00e-103 367.00
IUUC-Obr-076018 Oryza brachyantha 45.40 1.00e-112 399.00
IUUC-Ogl-077254 Oryza glaberrima 46.76 2.00e-102 365.00
IUUC-Ogu-078562 Oryza glumaepatula 46.76 6.00e-102 363.00
IUUC-Oin-080094 Oryza indica 46.76 2.00e-102 365.00
IUUC-Olo-080798 Oryza longistaminata 47.82 3.00e-110 392.00
IUUC-Ome-081186 Oryza meridionalis 47.20 4.00e-111 395.00
IUUC-Oni-082243 Oryza nivara 46.76 2.00e-102 365.00
IUUC-Opu-083901 Oryza punctata 46.88 2.00e-110 392.00
IUUC-Oru-084357 Oryza rufipogon 46.76 3.00e-102 364.00
IUUC-Osa-086094 Oryza sativa 46.76 2.00e-102 364.00
IUUC-Ola-086907 Oryzias latipes 45.66 1.00e-110 392.00
IUUC-Olu-087647 Ostreococcus lucimarinus 49.06 6.00e-120 423.00
IUUC-Oga-088184 Otolemur garnettii 49.72 9.00e-135 472.00
IUUC-Oar-090023 Ovis aries 48.20 2.00e-125 441.00
IUUC-Ptr-090935 Pan troglodytes 50.98 1.00e-132 465.00
IUUC-Pan-091845 Papio anubis 50.37 2.00e-138 484.00
IUUC-Psi-093188 Pelodiscus sinensis 49.52 7.00e-139 486.00
IUUC-Pma-094187 Petromyzon marinus 47.00 8.00e-125 439.00
IUUC-Pno-094809 Phaeosphaeria nodorum 37.53 3.00e-92 332.00
IUUC-Ppa-095457 Physcomitrella patens 47.56 1.00e-106 379.00
IUUC-Pfo-097429 Poecilia formosa 39.85 9.00e-98 349.00
IUUC-Pab-098603 Pongo abelii 50.37 2.00e-138 485.00
IUUC-Pop-098890 Populus trichocarpa 46.63 2.00e-108 385.00
IUUC-Pca-101062 Procavia capensis 49.81 4.00e-136 477.00
IUUC-Ppe-101865 Prunus persica 48.56 1.00e-102 365.00
IUUC-Pva-102925 Pteropus vampyrus 50.37 9.00e-140 489.00
IUUC-Pyt-104693 Pyrenophora triticirepentis 42.09 2.00e-88 319.00
IUUC-Rno-106005 Rattus norvegicus 50.00 3.00e-134 471.00
IUUC-Sha-107472 Sarcophilus harrisii 49.25 4.00e-133 467.00
IUUC-Sja-107919 Schizosaccharomyces japonicus 45.99 5.00e-92 330.00
IUUC-Spo-108075 Schizosaccharomyces pombe 45.01 2.00e-91 328.00
IUUC-Smo-108922 Selaginella moellendorffii 47.30 1.00e-121 429.00
IUUC-Sit-110032 Setaria italica 45.02 3.00e-111 394.00
IUUC-Sly-111202 Solanum lycopersicum 47.72 1.00e-110 392.00
IUUC-Stu-112024 Solanum tuberosum 47.63 4.00e-111 394.00
IUUC-Sar-113092 Sorex araneus 48.78 1.00e-126 445.00
IUUC-Sbi-114558 Sorghum bicolor 47.14 3.00e-110 391.00
IUUC-Ssc-115710 Sus scrofa 50.19 5.00e-138 483.00
IUUC-Tgu-117100 Taeniopygia guttata 49.15 3.00e-135 474.00
IUUC-Tru-118184 Takifugu rubripes 45.84 1.00e-103 369.00
IUUC-Tsy-118931 Tarsius syrichta 45.05 1.00e-69 256.00
IUUC-Tni-120474 Tetraodon nigroviridis 43.67 6.00e-113 400.00
IUUC-Tca-120949 Theobroma cacao 43.59 2.00e-109 388.00
IUUC-Tae-123765 Triticum aestivum 46.49 1.00e-112 399.00
IUUC-Tur-126018 Triticum urartu 45.22 5.00e-105 374.00
IUUC-Tbe-127384 Tupaia belangeri 60.40 9.00e-107 379.00
IUUC-Ttr-128511 Tursiops truncatus 50.56 5.00e-139 486.00
IUUC-Vpa-130775 Vicugna pacos 43.10 5.00e-67 247.00
IUUC-Vvi-131245 Vitis vinifera 48.58 2.00e-103 368.00
IUUC-Xtr-131993 Xenopus tropicalis 48.78 6.00e-134 469.00
IUUC-Xma-133332 Xiphophorus maculatus 45.85 1.00e-113 402.00
Created Date 25-Jun-2017

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