iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132256.18	ENST00000380034.7	ENSP00000369373.3
ENSG00000132256.18	ENST00000380027.5	ENSP00000369366.1
ENSG00000132256.18	ENST00000433961.5	ENSP00000393052.1
ENSG00000132256.18	ENST00000396847.7	ENSP00000380058.3
ENSG00000132256.18	ENST00000438025.5	ENSP00000398196.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18312418; 26101372

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.00e-05	27.1	9	79
E3 activity/RING/RING	2.30e-08	36.0	15	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl.....asggktcPvtrqplteedlvPnltlrrliqa 67
           v ee  CpI lel ++P  l +G+++ ++++         ++g+++cPv+r + ++e++ Pn  + +++++
   Q: 9    VKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHkksmlDKGESSCPVCRISYQPENIRPNRHVANIVEK 79
           78999*************************975322223377777*****************998887776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ Cl + + ++ + ++e +CP+Cr
   Q: 15   CPICLELLTQ-PLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCR 59
           ********99.***************555457788**********8 PP

Organism

Homo sapiens

Functional Description
(View)

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

Protein Sequence
(Fasta)

MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK GESSCPVCRI 60
SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS 120

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Nucleotide Sequence
(Fasta)

TCCGTTCTGC TGGAACACAA ACGCGCTTCT CAGTTTCTCT GGAGGAACTT GGTTGGCGAA 60
GAGCTTGGCG CTTCTTGTAA ACCTTGTCCC GCTGGACAAA GACTTGTGAA GGAACACGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0042802--F:identical protein binding
GO:0030674--F:protein binding, bridging
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002218--P:activation of innate immune response
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0070206--P:protein trimerization
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

KEGG

hsa:85363

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	57.99	3.00e-159	555.00
IUUC-Cja-019944	Callithrix jacchus	68.83	0.00e+00	658.00
IUUC-Csa-023609	Chlorocebus sabaeus	83.30	0.00e+00	879.00
IUUC-Cho-024416	Choloepus hoffmanni	62.89	2.00e-93	336.00
IUUC-Dor-030700	Dipodomys ordii	53.24	5.00e-148	517.00
IUUC-Ete-033021	Echinops telfairi	54.47	3.00e-126	445.00
IUUC-Eeu-034968	Erinaceus europaeus	50.65	1.00e-116	412.00
IUUC-Ggo-044783	Gorilla gorilla	92.90	0.00e+00	905.00
IUUC-Mcc-055525	Macaca mulatta	86.92	0.00e+00	895.00
IUUC-Mmr-061336	Microcebus murinus	63.20	5.00e-154	537.00
IUUC-Mlu-067695	Myotis lucifugus	60.12	9.00e-158	550.00
IUUC-Nle-069081	Nomascus leucogenys	88.66	0.00e+00	869.00
IUUC-Opr-071057	Ochotona princeps	53.16	1.00e-132	466.00
IUUC-Oar-090073	Ovis aries	56.72	7.00e-145	507.00
IUUC-Ptr-090927	Pan troglodytes	96.15	0.00e+00	954.00
IUUC-Pan-092730	Papio anubis	86.92	0.00e+00	893.00
IUUC-Pab-098782	Pongo abelii	93.51	0.00e+00	936.00
IUUC-Pca-100502	Procavia capensis	52.73	8.00e-134	470.00
IUUC-Sar-113094	Sorex araneus	49.60	6.00e-112	397.00
IUUC-Ssc-115715	Sus scrofa	57.88	9.00e-146	510.00
IUUC-Tsy-119055	Tarsius syrichta	62.42	3.00e-169	588.00
IUUC-Tbe-127426	Tupaia belangeri	53.41	2.00e-132	465.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence