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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046240
UUCD1 version UUC-HoS-00225
Ensembl Protein ID ENSP00000310686.5
UniProt Accession Q8N3Y1; Q9UK95; FBXW8_HUMAN
Genbank Protein ID AAF03129.1; AAH37296.1
Protein Name F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8; F-box only protein 29
Genbank Nucleotide ID AF176707; AC026368
Gene Name FBXW8; FBW6; FBW8; FBX29; FBXO29; FBXW6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174989.12 ENST00000309909.9 ENSP00000310686.5
ENSG00000174989.12 ENST00000455858.2 ENSP00000389144.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 17998335; 14990695; 18539111; 18498745; 17205132; 17588513
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 5.70e-05 24.9 115 159
E3 adaptor/Cullin RING/DCX/DWD 2.90e-12 48.0 436 467
UBD/Beta-Prp 9.00e-45 154.8 204 507
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
              +lp+e+ ++i+++ld++el+r+a+v+++w+ +a+++ lw ++
   Q: 115  FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
           5679*****************************999999999765 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 7    tclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++  s  +l+vsG+ Dg +++ Dlr+g+ 
   Q: 436  TCVNLsdSPpNLMVSGNMDGRVRIHDLRSGNI 467
           89999873359*****************9975 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlstgkc 86
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+tgk+
   Q: 204  ELEHVPDTVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRTGKY 291
           67888999***8888..************************9999777777789999999*********..9******************** PP
   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltg 177
            ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++  rtl  
   Q: 292  PVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETrRYPVAVAAAGDLM-YLLKAEDSARTLLY 382
           999999**********************************************************************8.************** PP
   S: 178  ghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsgdllktlqlh 263
           +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg++  +l+ h
   Q: 383  AHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAH 474
           ***********************************************************78899**************************** PP
   S: 264  nssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           + +v++v++   +d+++v+g+e++ v +w++++n++
   Q: 475  QLRVSAVQM---DDWKIVSGGEEGLVSVWDYRMNQK 507
           *******99...********************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).
 Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).
Protein Sequence
(Fasta)
MDDYSLDEFR RRWQEELAQA QAPKKRRRPE AAERRARRPE VGSGRGEQAS GDPALAQRLL 60
EGAGRPPAAR ATRAEGQDVA SRSRSPLARE GAGGGEQLVD QLIRDLNEMN DVPFFDIQLP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046240|E3,F-box;UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCGGACA CTTCCCTGGG CGGGACTGTC TCGTGGCACC CGGTGGAACC GAGGAGAACG 60
TGGAGCGCCG GGAGCGGCGA ATATGGACGA CTACAGCCTG GATGAGTTCC GTCGGCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046240|E3,F-box;UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060712--P:spongiotrophoblast layer development
KEGG hsa:26259
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001274 Ailuropoda melanoleuca 88.03 0.00e+00 945.00
IUUC-Apl-003239 Anas platyrhynchos 61.30 0.00e+00 674.00
IUUC-Aca-004756 Anolis carolinensis 57.88 3.00e-129 454.00
IUUC-Ame-011198 Astyanax mexicanus 54.30 1.00e-57 216.00
IUUC-Bta-012430 Bos taurus 61.25 4.00e-159 555.00
IUUC-Cja-019131 Callithrix jacchus 90.13 0.00e+00 1030.00
IUUC-Cfa-021022 Canis familiaris 78.70 0.00e+00 920.00
IUUC-Cpo-021898 Cavia porcellus 77.19 0.00e+00 902.00
IUUC-Csa-023452 Chlorocebus sabaeus 96.82 0.00e+00 1134.00
IUUC-Cho-024759 Choloepus hoffmanni 75.75 0.00e+00 835.00
IUUC-Dre-028123 Danio rerio 45.10 2.00e-141 496.00
IUUC-Dno-029045 Dasypus novemcinctus 87.31 0.00e+00 831.00
IUUC-Dor-030433 Dipodomys ordii 77.09 0.00e+00 769.00
IUUC-Ete-032465 Echinops telfairi 79.65 0.00e+00 744.00
IUUC-Eca-034134 Equus caballus 87.20 0.00e+00 898.00
IUUC-Eeu-035047 Erinaceus europaeus 76.94 0.00e+00 768.00
IUUC-Fca-036574 Felis catus 87.50 0.00e+00 882.00
IUUC-Fal-037665 Ficedula albicollis 59.28 4.00e-171 594.00
IUUC-Gmo-039137 Gadus morhua 46.83 2.00e-68 252.00
IUUC-Gga-040711 Gallus gallus 59.03 0.00e+00 663.00
IUUC-Gac-041675 Gasterosteus aculeatus 50.00 4.00e-50 190.00
IUUC-Ggo-045331 Gorilla gorilla 98.98 0.00e+00 1017.00
IUUC-Itr-048412 Ictidomys tridecemlineatus 88.21 0.00e+00 882.00
IUUC-Loc-052631 Lepisosteus oculatus 53.17 1.00e-163 570.00
IUUC-Laf-054127 Loxodonta africana 72.73 8.00e-56 209.00
IUUC-Mcc-055083 Macaca mulatta 97.66 0.00e+00 1119.00
IUUC-Mga-060113 Meleagris gallopavo 62.22 0.00e+00 646.00
IUUC-Mmr-061780 Microcebus murinus 86.48 0.00e+00 922.00
IUUC-Mdo-063066 Monodelphis domestica 61.35 0.00e+00 707.00
IUUC-Mmu-063524 Mus musculus 76.92 0.00e+00 842.00
IUUC-Mpu-066913 Mustela putorius furo 87.84 0.00e+00 919.00
IUUC-Mlu-067924 Myotis lucifugus 83.58 0.00e+00 932.00
IUUC-Nle-069558 Nomascus leucogenys 97.38 0.00e+00 1057.00
IUUC-Opr-070506 Ochotona princeps 83.16 0.00e+00 906.00
IUUC-Ont-071514 Oreochromis niloticus 47.94 7.00e-144 504.00
IUUC-Ocu-074477 Oryctolagus cuniculus 85.57 0.00e+00 865.00
IUUC-Ola-087416 Oryzias latipes 43.97 3.00e-144 505.00
IUUC-Oga-088643 Otolemur garnettii 86.62 0.00e+00 942.00
IUUC-Oar-090172 Ovis aries 86.48 0.00e+00 885.00
IUUC-Ptr-090870 Pan troglodytes 99.50 0.00e+00 1142.00
IUUC-Pan-092017 Papio anubis 96.49 0.00e+00 1134.00
IUUC-Psi-093794 Pelodiscus sinensis 63.23 0.00e+00 651.00
IUUC-Pfo-096192 Poecilia formosa 50.10 2.00e-146 512.00
IUUC-Pab-097882 Pongo abelii 97.99 0.00e+00 1118.00
IUUC-Pca-100902 Procavia capensis 83.14 6.00e-155 541.00
IUUC-Pva-103139 Pteropus vampyrus 85.48 0.00e+00 955.00
IUUC-Rno-105798 Rattus norvegicus 80.08 0.00e+00 849.00
IUUC-Sha-106576 Sarcophilus harrisii 64.96 0.00e+00 667.00
IUUC-Ssc-115923 Sus scrofa 76.88 0.00e+00 919.00
IUUC-Tgu-116667 Taeniopygia guttata 53.07 5.00e-108 384.00
IUUC-Tru-118323 Takifugu rubripes 43.09 1.00e-135 476.00
IUUC-Tsy-118818 Tarsius syrichta 70.08 5.00e-97 348.00
IUUC-Tni-120438 Tetraodon nigroviridis 42.49 2.00e-133 469.00
IUUC-Tbe-127784 Tupaia belangeri 83.98 1.00e-97 350.00
IUUC-Ttr-128288 Tursiops truncatus 78.32 0.00e+00 811.00
IUUC-Vpa-130307 Vicugna pacos 84.03 0.00e+00 801.00
Created Date 25-Jun-2017

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