iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000064726.9	ENST00000261721.8	ENSP00000261721.4
ENSG00000064726.9	ENST00000379403.2	ENSP00000368713.2
ENSG00000064726.9	ENST00000559652.5	ENSP00000453104.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.40e-14	55.1	70	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    Dvilvv..........ggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv +v+          g ++++ah+ vLaa S vF a+f++++  +  + ++e+ dv+p +f all+FlY++++++
   Q: 70   DVRFVLgkgrgaaaagGPQRIPAHRFVLAAGSAVFDAMFNGGMATT--SAEIELPDVEPAAFLALLRFLYSDEVQI 143
           6666666666666654489*************************88..69**********************9986 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MASLGPAAAG EQASGAEAEP GPAGPPPPPS PSSLGPLLPL QREPLYNWQA TKASLKERFA 60
FLFNSELLSD VRFVLGKGRG AAAAGGPQRI PAHRFVLAAG SAVFDAMFNG GMATTSAEIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCCTGTTA CACCTCCCGC GGCCGCGCAC AGCGGCAACC CGGGCGTGCG GGGGCGCGCG 60
CGGTCAGGGA GGGGCCTGCG GAGGCGCGAG GCCCCCGGAA GCGCCTTTCC CGGAAGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0000932--C:P-body
GO:0043234--C:protein complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043393--P:regulation of protein binding
GO:0030162--P:regulation of proteolysis

KEGG

hsa:53339

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002337	Ailuropoda melanoleuca	99.10	0.00e+00	870.00
IUUC-Aca-004409	Anolis carolinensis	92.44	0.00e+00	832.00
IUUC-Bta-012943	Bos taurus	94.20	0.00e+00	867.00
IUUC-Cja-018932	Callithrix jacchus	99.55	0.00e+00	898.00
IUUC-Cpo-021442	Cavia porcellus	98.63	0.00e+00	862.00
IUUC-Csa-023065	Chlorocebus sabaeus	99.55	0.00e+00	900.00
IUUC-Cho-024988	Choloepus hoffmanni	97.42	9.00e-112	397.00
IUUC-Dno-029188	Dasypus novemcinctus	98.42	0.00e+00	863.00
IUUC-Gmo-039530	Gadus morhua	88.21	0.00e+00	766.00
IUUC-Gac-041292	Gasterosteus aculeatus	88.46	0.00e+00	789.00
IUUC-Ggo-044634	Gorilla gorilla	100.00	0.00e+00	878.00
IUUC-Itr-048421	Ictidomys tridecemlineatus	99.10	0.00e+00	875.00
IUUC-Loc-052236	Lepisosteus oculatus	90.05	0.00e+00	822.00
IUUC-Laf-054062	Loxodonta africana	99.10	0.00e+00	872.00
IUUC-Meu-056514	Macropus eugenii	77.53	0.00e+00	636.00
IUUC-Mmr-060924	Microcebus murinus	99.55	0.00e+00	873.00
IUUC-Mdo-062855	Monodelphis domestica	96.63	0.00e+00	864.00
IUUC-Mmu-063259	Mus musculus	98.87	0.00e+00	886.00
IUUC-Ont-072535	Oreochromis niloticus	84.39	0.00e+00	722.00
IUUC-Ocu-074518	Oryctolagus cuniculus	98.92	0.00e+00	763.00
IUUC-Ola-087042	Oryzias latipes	87.00	0.00e+00	752.00
IUUC-Oga-088986	Otolemur garnettii	99.77	0.00e+00	878.00
IUUC-Ptr-091613	Pan troglodytes	100.00	0.00e+00	878.00
IUUC-Pan-092323	Papio anubis	99.77	0.00e+00	904.00
IUUC-Psi-094048	Pelodiscus sinensis	92.15	0.00e+00	833.00
IUUC-Pfo-097347	Poecilia formosa	87.78	0.00e+00	797.00
IUUC-Pab-098330	Pongo abelii	99.77	0.00e+00	877.00
IUUC-Pca-100420	Procavia capensis	99.19	2.00e-135	475.00
IUUC-Rno-105116	Rattus norvegicus	98.87	0.00e+00	888.00
IUUC-Ssc-115374	Sus scrofa	96.50	0.00e+00	873.00
IUUC-Tgu-117423	Taeniopygia guttata	92.17	0.00e+00	850.00
IUUC-Tru-118529	Takifugu rubripes	87.53	0.00e+00	801.00
IUUC-Tsy-118878	Tarsius syrichta	98.78	3.00e-131	461.00
IUUC-Tni-120187	Tetraodon nigroviridis	87.36	0.00e+00	782.00
IUUC-Vpa-130673	Vicugna pacos	97.43	0.00e+00	816.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence