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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064344
UUCD1 version UUC-MuM-00528
Ensembl Protein ID ENSMUSP00000030439.8
UniProt Accession Q6PDX6; A2APP0; Q3T9M4; Q3V3D7; Q8JZY5; RN220_MOUSE
Genbank Protein ID BAE20604.1; BAE42996.1; CAM20839.1; CAM20837.1; CAM23616.1; AAH34875.1; AAH56359.1; AAH58415.1
Protein Name E3 ubiquitin-protein ligase Rnf220; RING finger protein 220; RING-type E3 ubiquitin transferase Rnf220
Genbank Nucleotide ID AK041785; AK172415; AL645740; AL844169; AL844169; BC034875; BC056359; BC058415
Gene Name Rnf220
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028677.18 ENSMUST00000030439.14 ENSMUSP00000030439.8
ENSMUSG00000028677.18 ENSMUST00000094853.8 ENSMUSP00000092449.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 97.88 0.00e+00 1095.00 IUUC-Hsa-045704
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (PubMed:20170641). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity).
 E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (PubMed:20170641). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity).
Protein Sequence
(Fasta)
MDLHRAAFKM ENSSYLPNPL ASPALMVLAS TAEASRDASI PCQQPRPFGV PVSVDKDVHI 60
PFTNGSYTFA SMYHRQGGVP GTFANRDFPP SLLHLHPQFA PPNLDCTPIS MLNHSGVGAF 120
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Protein Fasta Sequence


>IUUC-Mmu-064344|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GTGTGTGAGT GTGAGAGAAT GTGTGCGTGC ATGTGTGTGT GAGTGTGTGT GTGCGCGCGC 60
GCGTGTGTGT GCGCCTCCGA GTCCCTGGGA GAGTGGAGGC TCATTCACTG ATTAGAGCCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064344|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031824--RNF220_mid
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF15926--RNF220
Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
KEGG mmu:66743
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002101 Ailuropoda melanoleuca 95.24 0.00e+00 1053.00
IUUC-Apl-003248 Anas platyrhynchos 91.90 0.00e+00 1031.00
IUUC-Aca-004242 Anolis carolinensis 72.04 3.00e-125 441.00
IUUC-Ame-010840 Astyanax mexicanus 77.13 0.00e+00 868.00
IUUC-Bta-013469 Bos taurus 98.23 0.00e+00 1097.00
IUUC-Cja-019668 Callithrix jacchus 92.22 5.00e-176 610.00
IUUC-Cfa-020783 Canis familiaris 98.23 0.00e+00 1097.00
IUUC-Cpo-022329 Cavia porcellus 97.53 0.00e+00 1091.00
IUUC-Csa-024183 Chlorocebus sabaeus 96.98 2.00e-148 517.00
IUUC-Cho-024989 Choloepus hoffmanni 93.60 0.00e+00 687.00
IUUC-Cin-025335 Ciona intestinalis 35.54 2.00e-21 95.50
IUUC-Csv-025998 Ciona savignyi 38.92 2.00e-21 94.40
IUUC-Dre-027666 Danio rerio 78.52 0.00e+00 874.00
IUUC-Dno-029877 Dasypus novemcinctus 88.70 5.00e-143 500.00
IUUC-Dor-030123 Dipodomys ordii 88.54 0.00e+00 937.00
IUUC-Dme-031847 Drosophila melanogaster 41.10 6.00e-35 141.00
IUUC-Ete-032907 Echinops telfairi 90.31 0.00e+00 801.00
IUUC-Eca-033571 Equus caballus 96.48 0.00e+00 1055.00
IUUC-Eeu-034827 Erinaceus europaeus 78.88 0.00e+00 718.00
IUUC-Fca-036595 Felis catus 96.82 0.00e+00 1055.00
IUUC-Fal-036741 Ficedula albicollis 92.77 0.00e+00 1052.00
IUUC-Gmo-038853 Gadus morhua 68.75 3.00e-163 568.00
IUUC-Gga-040915 Gallus gallus 89.36 0.00e+00 1044.00
IUUC-Gac-041804 Gasterosteus aculeatus 75.73 0.00e+00 841.00
IUUC-Ggo-045244 Gorilla gorilla 93.09 0.00e+00 627.00
IUUC-Hsa-045704 Homo sapiens 97.88 0.00e+00 1095.00
IUUC-Itr-048567 Ictidomys tridecemlineatus 95.97 0.00e+00 1068.00
IUUC-Lch-049680 Latimeria chalumnae 94.29 7.00e-119 419.00
IUUC-Loc-052023 Lepisosteus oculatus 83.33 0.00e+00 960.00
IUUC-Laf-053349 Loxodonta africana 96.82 0.00e+00 1086.00
IUUC-Mcc-054596 Macaca mulatta 97.70 0.00e+00 1094.00
IUUC-Meu-056519 Macropus eugenii 86.27 0.00e+00 974.00
IUUC-Mga-059955 Meleagris gallopavo 90.02 0.00e+00 1008.00
IUUC-Mmr-061479 Microcebus murinus 97.20 0.00e+00 661.00
IUUC-Mdo-061811 Monodelphis domestica 93.66 0.00e+00 1053.00
IUUC-Mpu-066890 Mustela putorius furo 93.67 0.00e+00 1030.00
IUUC-Mlu-067364 Myotis lucifugus 90.08 3.00e-180 624.00
IUUC-Nle-070000 Nomascus leucogenys 97.01 0.00e+00 1084.00
IUUC-Opr-071140 Ochotona princeps 72.66 0.00e+00 793.00
IUUC-Ont-072377 Oreochromis niloticus 76.13 0.00e+00 827.00
IUUC-Oan-072918 Ornithorhynchus anatinus 95.69 2.00e-119 421.00
IUUC-Ocu-074560 Oryctolagus cuniculus 96.64 0.00e+00 1075.00
IUUC-Ola-086788 Oryzias latipes 58.22 6.00e-161 560.00
IUUC-Oga-088709 Otolemur garnettii 98.23 0.00e+00 1097.00
IUUC-Oar-089330 Ovis aries 90.37 0.00e+00 625.00
IUUC-Ptr-091304 Pan troglodytes 96.92 0.00e+00 661.00
IUUC-Pan-091776 Papio anubis 96.64 0.00e+00 658.00
IUUC-Psi-093769 Pelodiscus sinensis 83.85 2.00e-160 558.00
IUUC-Pma-094615 Petromyzon marinus 52.52 2.00e-36 144.00
IUUC-Pfo-096349 Poecilia formosa 73.39 0.00e+00 826.00
IUUC-Pab-098557 Pongo abelii 93.64 0.00e+00 1026.00
IUUC-Pca-100758 Procavia capensis 96.83 0.00e+00 1080.00
IUUC-Pva-102552 Pteropus vampyrus 97.53 0.00e+00 1081.00
IUUC-Rno-105430 Rattus norvegicus 91.64 0.00e+00 651.00
IUUC-Sha-107584 Sarcophilus harrisii 86.48 5.00e-164 570.00
IUUC-Sar-113640 Sorex araneus 96.56 0.00e+00 751.00
IUUC-Ssc-116017 Sus scrofa 88.44 2.00e-143 501.00
IUUC-Tgu-116450 Taeniopygia guttata 93.29 0.00e+00 1057.00
IUUC-Tru-117573 Takifugu rubripes 73.52 0.00e+00 775.00
IUUC-Tsy-118997 Tarsius syrichta 96.56 0.00e+00 748.00
IUUC-Tni-120609 Tetraodon nigroviridis 76.40 0.00e+00 825.00
IUUC-Tbe-127547 Tupaia belangeri 78.67 0.00e+00 648.00
IUUC-Ttr-128945 Tursiops truncatus 92.06 0.00e+00 1011.00
IUUC-Vpa-130219 Vicugna pacos 88.50 0.00e+00 953.00
IUUC-Xtr-132389 Xenopus tropicalis 89.40 0.00e+00 1035.00
Created Date 25-Jun-2017

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