iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028960.18	ENSMUST00000103212.9	ENSMUSP00000099501.3
ENSMUSG00000028960.18	ENSMUST00000174343.7	ENSMUSP00000134556.1
ENSMUSG00000028960.18	ENSMUST00000172836.1	ENSMUSP00000134452.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	15466860

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	4.60e-22	79.0	1099	1170

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
            p+ef++p++ +lM+dPv lpsG ++drs I ++l ++ + +P++rq lte++l P  +l++ iqaw+ e++s
   Q: 1099 APDEFRDPLMDTLMTDPVRLPSGTVMDRSIILRHLLNSPT-DPFNRQMLTESMLEPVPELKEQIQAWMREKQS 1170
           79**********************************9998.****************************9986 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

Protein Sequence
(Fasta)

MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 60
TPATSPIGAA GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGAGGGG GTGGGGCAGG GGGCGGGGAC AGGATGCAAG CGAAGAGGAA ATCGGCGGCG 60
CGACGCCCGC TGCTTATTGG CTGGCGAATC CCAGAGCGAG AAGCCCCGCC TCCCCGGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX

Pfam

PF04564--U-box
PF10408--Ufd2P_core

SMART

SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0051082--F:unfolded protein binding
GO:0044257--P:cellular protein catabolic process
GO:0008626--P:granzyme-mediated apoptotic signaling pathway
GO:0031175--P:neuron projection development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006457--P:protein folding
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0034976--P:response to endoplasmic reticulum stress
GO:0009411--P:response to UV
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0003222--P:ventricular trabecula myocardium morphogenesis

KEGG

mmu:63958

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000585	Aegilops tauschii	32.83	1.00e-98	354.00
IUUC-Aml-002396	Ailuropoda melanoleuca	97.76	0.00e+00	1716.00
IUUC-Atr-002479	Amborella trichopoda	31.78	1.00e-100	360.00
IUUC-Apl-003747	Anas platyrhynchos	93.38	0.00e+00	1677.00
IUUC-Aca-004866	Anolis carolinensis	92.47	0.00e+00	1652.00
IUUC-Aly-006300	Arabidopsis lyrata	30.41	4.00e-88	320.00
IUUC-Ath-006962	Arabidopsis thaliana	30.50	1.00e-85	311.00
IUUC-Ago-007880	Ashbya gossypii	29.97	8.00e-80	292.00
IUUC-Acl-008289	Aspergillus clavatus	30.41	2.00e-102	367.00
IUUC-Afl-008711	Aspergillus flavus	31.15	2.00e-107	384.00
IUUC-Afu-008766	Aspergillus fumigatus	30.76	1.00e-106	381.00
IUUC-Ani-009126	Aspergillus nidulans	30.78	5.00e-104	372.00
IUUC-Ang-009837	Aspergillus niger	30.56	5.00e-103	369.00
IUUC-Aor-009919	Aspergillus oryzae	30.73	2.00e-103	370.00
IUUC-Ate-010300	Aspergillus terreus	31.63	5.00e-109	389.00
IUUC-Ame-011355	Astyanax mexicanus	84.61	0.00e+00	1573.00
IUUC-Bgr-011995	Blumeria graminis	29.89	1.00e-101	364.00
IUUC-Bta-013056	Bos taurus	97.99	0.00e+00	1715.00
IUUC-Bci-013605	Botrytis cinerea	28.60	3.00e-90	327.00
IUUC-Bdi-015032	Brachypodium distachyon	30.57	6.00e-93	335.00
IUUC-Bol-016124	Brassica oleracea	30.75	2.00e-95	344.00
IUUC-Bra-017426	Brassica rapa	30.60	1.00e-95	344.00
IUUC-Cel-018606	Caenorhabditis elegans	30.84	5.00e-99	355.00
IUUC-Cja-018872	Callithrix jacchus	97.65	0.00e+00	1721.00
IUUC-Cfa-020045	Canis familiaris	97.65	0.00e+00	1713.00
IUUC-Cpo-022309	Cavia porcellus	96.25	0.00e+00	2037.00
IUUC-Cre-022726	Chlamydomonas reinhardtii	29.87	1.00e-49	190.00
IUUC-Csa-024003	Chlorocebus sabaeus	96.35	0.00e+00	1087.00
IUUC-Cho-025092	Choloepus hoffmanni	96.84	0.00e+00	676.00
IUUC-Cin-025533	Ciona intestinalis	47.17	0.00e+00	831.00
IUUC-Csv-026081	Ciona savignyi	64.52	3.00e-60	224.00
IUUC-Cgl-026710	Colletotrichum gloeosporioides	31.44	5.00e-107	382.00
IUUC-Cne-027098	Cryptococcus neoformans	29.75	4.00e-108	386.00
IUUC-Cme-027352	Cyanidioschyzon merolae	32.51	2.00e-87	317.00
IUUC-Dre-027979	Danio rerio	83.91	0.00e+00	1514.00
IUUC-Dno-029282	Dasypus novemcinctus	97.76	0.00e+00	1712.00
IUUC-Dor-030904	Dipodomys ordii	78.53	0.00e+00	739.00
IUUC-Dse-031393	Dothistroma septosporum	29.74	1.00e-99	358.00
IUUC-Dme-031666	Drosophila melanogaster	39.04	0.00e+00	692.00
IUUC-Ete-032519	Echinops telfairi	97.85	1.00e-178	621.00
IUUC-Eca-033778	Equus caballus	97.32	0.00e+00	1701.00
IUUC-Eeu-035315	Erinaceus europaeus	89.16	0.00e+00	872.00
IUUC-Fca-035658	Felis catus	97.43	0.00e+00	1705.00
IUUC-Fal-037638	Ficedula albicollis	92.68	0.00e+00	1666.00
IUUC-Fox-037909	Fusarium oxysporum	29.17	3.00e-96	347.00
IUUC-Fso-038406	Fusarium solani	29.59	3.00e-96	347.00
IUUC-Gmo-039379	Gadus morhua	79.71	0.00e+00	1745.00
IUUC-Ggr-039851	Gaeumannomyces graminis	31.65	1.00e-105	378.00
IUUC-Gga-041136	Gallus gallus	93.36	0.00e+00	1679.00
IUUC-Gac-041910	Gasterosteus aculeatus	80.37	0.00e+00	1753.00
IUUC-Gma-043587	Glycine max	31.08	2.00e-93	337.00
IUUC-Ggo-045354	Gorilla gorilla	88.93	0.00e+00	1834.00
IUUC-Hsa-046880	Homo sapiens	97.77	0.00e+00	1748.00
IUUC-Hvu-047157	Hordeum vulgare	32.87	9.00e-94	338.00
IUUC-Itr-048213	Ictidomys tridecemlineatus	97.60	0.00e+00	636.00
IUUC-Kpa-049211	Komagataella pastoris	28.56	1.00e-78	288.00
IUUC-Lch-050534	Latimeria chalumnae	87.77	0.00e+00	1592.00
IUUC-Lpe-051022	Leersia perrieri	31.14	1.00e-92	334.00
IUUC-Loc-052622	Lepisosteus oculatus	85.88	0.00e+00	1545.00
IUUC-Lma-053241	Leptosphaeria maculans	30.21	8.00e-100	358.00
IUUC-Laf-053646	Loxodonta africana	97.65	0.00e+00	1714.00
IUUC-Mcc-055588	Macaca mulatta	97.88	0.00e+00	1720.00
IUUC-Meu-055999	Macropus eugenii	78.63	0.00e+00	1321.00
IUUC-Mor-057064	Magnaporthe oryzae	30.68	2.00e-105	377.00
IUUC-Mpo-057452	Magnaporthe poae	31.87	1.00e-106	381.00
IUUC-Mtr-058016	Medicago truncatula	29.47	4.00e-100	359.00
IUUC-Mla-058887	Melampsora laricipopulina	32.81	3.00e-109	389.00
IUUC-Mga-059497	Meleagris gallopavo	93.13	0.00e+00	1674.00
IUUC-Mvi-060343	Microbotryum violaceum	34.38	8.00e-114	405.00
IUUC-Mmr-061173	Microcebus murinus	89.06	0.00e+00	1480.00
IUUC-Mdo-062102	Monodelphis domestica	94.46	0.00e+00	2046.00
IUUC-Mac-065531	Musa acuminata	30.86	3.00e-96	347.00
IUUC-Mpu-066624	Mustela putorius furo	66.01	0.00e+00	1041.00
IUUC-Mlu-068018	Myotis lucifugus	96.98	0.00e+00	1697.00
IUUC-Nfi-068590	Neosartorya fischeri	31.19	3.00e-108	386.00
IUUC-Ncr-068901	Neurospora crassa	31.24	5.00e-104	372.00
IUUC-Nle-069605	Nomascus leucogenys	96.65	0.00e+00	1689.00
IUUC-Opr-071011	Ochotona princeps	83.01	0.00e+00	827.00
IUUC-Ont-072304	Oreochromis niloticus	83.95	0.00e+00	1480.00
IUUC-Oan-073410	Ornithorhynchus anatinus	96.33	0.00e+00	1096.00
IUUC-Ocu-074910	Oryctolagus cuniculus	96.96	0.00e+00	1711.00
IUUC-Oba-075073	Oryza barthii	31.32	9.00e-99	355.00
IUUC-Obr-076452	Oryza brachyantha	31.44	7.00e-97	348.00
IUUC-Ogl-077141	Oryza glaberrima	31.11	7.00e-99	355.00
IUUC-Ogu-078116	Oryza glumaepatula	31.11	5.00e-99	356.00
IUUC-Oin-079066	Oryza indica	31.23	3.00e-99	356.00
IUUC-Olo-080253	Oryza longistaminata	29.43	8.00e-86	311.00
IUUC-Ome-081263	Oryza meridionalis	30.99	4.00e-98	353.00
IUUC-Oni-082019	Oryza nivara	31.23	5.00e-99	356.00
IUUC-Opu-083558	Oryza punctata	31.36	3.00e-99	356.00
IUUC-Oru-085002	Oryza rufipogon	31.11	9.00e-99	355.00
IUUC-Osa-085980	Oryza sativa	31.23	4.00e-99	356.00
IUUC-Ola-086323	Oryzias latipes	81.01	0.00e+00	1430.00
IUUC-Olu-087901	Ostreococcus lucimarinus	29.94	4.00e-101	362.00
IUUC-Oga-087969	Otolemur garnettii	93.86	0.00e+00	1598.00
IUUC-Oar-090020	Ovis aries	94.54	0.00e+00	1641.00
IUUC-Ptr-091589	Pan troglodytes	97.77	0.00e+00	1750.00
IUUC-Pan-091718	Papio anubis	98.17	0.00e+00	856.00
IUUC-Psi-093013	Pelodiscus sinensis	92.95	0.00e+00	1684.00
IUUC-Pma-094627	Petromyzon marinus	74.87	0.00e+00	628.00
IUUC-Pno-094840	Phaeosphaeria nodorum	30.04	7.00e-106	379.00
IUUC-Ppa-095989	Physcomitrella patens	29.06	2.00e-98	353.00
IUUC-Pfo-096436	Poecilia formosa	85.07	0.00e+00	1532.00
IUUC-Pab-098275	Pongo abelii	86.65	0.00e+00	1758.00
IUUC-Pop-098797	Populus trichocarpa	30.39	2.00e-103	370.00
IUUC-Pca-100478	Procavia capensis	72.56	0.00e+00	670.00
IUUC-Ppe-101230	Prunus persica	30.71	8.00e-104	372.00
IUUC-Pva-102459	Pteropus vampyrus	92.73	0.00e+00	1600.00
IUUC-Pgr-103485	Puccinia graminis	32.81	4.00e-109	389.00
IUUC-Ptt-104001	Puccinia triticina	41.77	5.00e-45	176.00
IUUC-Pte-104084	Pyrenophora teres	31.84	2.00e-112	400.00
IUUC-Pyt-104484	Pyrenophora triticirepentis	31.72	2.00e-111	397.00
IUUC-Rno-105719	Rattus norvegicus	98.81	0.00e+00	2136.00
IUUC-Sce-106135	Saccharomyces cerevisiae	28.95	1.00e-77	285.00
IUUC-Sha-106760	Sarcophilus harrisii	94.43	0.00e+00	1979.00
IUUC-Sja-107698	Schizosaccharomyces japonicus	32.59	5.00e-118	419.00
IUUC-Spo-108076	Schizosaccharomyces pombe	32.85	2.00e-106	380.00
IUUC-Ssl-108624	Sclerotinia sclerotiorum	29.41	9.00e-102	365.00
IUUC-Smo-108769	Selaginella moellendorffii	29.20	7.00e-92	332.00
IUUC-Sit-109949	Setaria italica	31.34	2.00e-94	340.00
IUUC-Sly-110973	Solanum lycopersicum	31.09	3.00e-83	303.00
IUUC-Stu-112372	Solanum tuberosum	29.84	4.00e-102	366.00
IUUC-Sar-113469	Sorex araneus	89.07	0.00e+00	1024.00
IUUC-Sbi-113828	Sorghum bicolor	31.13	6.00e-98	352.00
IUUC-Sre-114967	Sporisorium reilianum	32.37	3.00e-103	370.00
IUUC-Ssc-115655	Sus scrofa	96.53	0.00e+00	1092.00
IUUC-Tgu-117290	Taeniopygia guttata	93.04	0.00e+00	1630.00
IUUC-Tru-118193	Takifugu rubripes	84.12	0.00e+00	1516.00
IUUC-Tsy-118926	Tarsius syrichta	97.21	0.00e+00	1708.00
IUUC-Tni-120862	Tetraodon nigroviridis	82.25	0.00e+00	1748.00
IUUC-Tca-121096	Theobroma cacao	31.28	9.00e-102	365.00
IUUC-Tre-122104	Trichoderma reesei	30.47	6.00e-99	356.00
IUUC-Tvi-122345	Trichoderma virens	30.76	2.00e-102	368.00
IUUC-Tae-124839	Triticum aestivum	32.83	8.00e-99	355.00
IUUC-Tur-126056	Triticum urartu	32.83	1.00e-98	354.00
IUUC-Tme-127074	Tuber melanosporum	32.77	9.00e-102	365.00
IUUC-Tbe-127533	Tupaia belangeri	93.41	0.00e+00	1636.00
IUUC-Ttr-128757	Tursiops truncatus	95.75	0.00e+00	1675.00
IUUC-Uma-129550	Ustilago maydis	33.07	1.00e-104	374.00
IUUC-Vda-129901	Verticillium dahliae	31.18	8.00e-104	372.00
IUUC-Vpa-130636	Vicugna pacos	96.58	0.00e+00	1027.00
IUUC-Vvi-130891	Vitis vinifera	30.82	5.00e-101	362.00
IUUC-Xtr-132364	Xenopus tropicalis	87.37	0.00e+00	1564.00
IUUC-Xma-133772	Xiphophorus maculatus	84.96	0.00e+00	1529.00
IUUC-Yli-134506	Yarrowia lipolytica	30.82	5.00e-84	306.00
IUUC-Zma-135695	Zea mays	31.19	9.00e-92	332.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence