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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063089
UUCD1 version UUC-MuM-00509
Ensembl Protein ID ENSMUSP00000095249.3
UniProt Accession Q6NZM9; Q3TRZ9; Q3U2J3; Q3V3Y4; HDAC4_MOUSE
Genbank Protein ID BAE43272.1; BAE33147.1; BAE36877.1; AAH66052.1
Protein Name Histone deacetylase 4
Genbank Nucleotide ID AK029933; AK155250; AK162369; BC066052
Gene Name Hdac4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026313.16 ENSMUST00000097644.8 ENSMUSP00000095249.3
ENSMUSG00000026313.16 ENSMUST00000187308.1 ENSMUSP00000140092.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
miRecordsRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 93.56 0.00e+00 1727.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
795 N/A {ECO:0000250}
Organism Mus musculus
Functional Description
(View)

Functional Description



     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Protein Sequence
(Fasta)
MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPTAVPMD LRLDHQFSLP 60
LEPALREQQL QQELLALKQK QQIQRQILIA EFQRQHEQLS RQHEAQLHEH IKQQQEMLAM 120
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Protein Fasta Sequence



>IUUC-Mmu-063089|E3,E3 activity/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT GAGAATAAGA GAATTGAAAA GATCGAGGTT 60
CGTTCTGGAA GCTGGAGTTC TTTGACTTCC ATCTGCCCCC ACATCTTGGA GTTCGCCCAG 120
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Nucleotide Fasta Sequence



>IUUC-Mmu-063089|E3,E3 activity/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0030017--C:sarcomere
GO:0017053--C:transcriptional repressor complex
GO:0030018--C:Z disc
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0003677--F:DNA binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0033558--F:protein deacetylase activity
GO:0019901--F:protein kinase binding
GO:0070491--F:repressing transcription factor binding
GO:0001025--F:RNA polymerase III transcription factor binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0071260--P:cellular response to mechanical stimulus
GO:0071374--P:cellular response to parathyroid hormone stimulus
GO:0071356--P:cellular response to tumor necrosis factor
GO:0006338--P:chromatin remodeling
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:1903428--P:positive regulation of reactive oxygen species biosynthetic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0051153--P:regulation of striated muscle cell differentiation
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0042493--P:response to drug
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

KEGG mmu:208727
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002279 Ailuropoda melanoleuca 91.33 0.00e+00 1682.00
IUUC-Apl-003250 Anas platyrhynchos 87.55 0.00e+00 1561.00
IUUC-Aca-004668 Anolis carolinensis 82.57 0.00e+00 1587.00
IUUC-Bta-013215 Bos taurus 91.47 0.00e+00 1668.00
IUUC-Cja-019816 Callithrix jacchus 93.26 0.00e+00 1729.00
IUUC-Cfa-020861 Canis familiaris 92.31 0.00e+00 1661.00
IUUC-Cpo-021562 Cavia porcellus 92.87 0.00e+00 1721.00
IUUC-Csa-023612 Chlorocebus sabaeus 93.11 0.00e+00 1713.00
IUUC-Csv-026359 Ciona savignyi 54.73 2.00e-94 338.00
IUUC-Dre-028284 Danio rerio 78.32 0.00e+00 1362.00
IUUC-Dno-029951 Dasypus novemcinctus 88.76 0.00e+00 1533.00
IUUC-Dor-030362 Dipodomys ordii 84.00 0.00e+00 1462.00
IUUC-Dme-031766 Drosophila melanogaster 59.34 2.00e-161 563.00
IUUC-Fca-036187 Felis catus 93.36 0.00e+00 1652.00
IUUC-Gmo-038473 Gadus morhua 77.14 0.00e+00 743.00
IUUC-Gga-040501 Gallus gallus 90.51 0.00e+00 1650.00
IUUC-Gac-042335 Gasterosteus aculeatus 69.81 0.00e+00 1253.00
IUUC-Ggo-045380 Gorilla gorilla 93.36 0.00e+00 1696.00
IUUC-Hsa-046925 Homo sapiens 93.73 0.00e+00 1734.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 94.13 0.00e+00 1662.00
IUUC-Lch-050325 Latimeria chalumnae 83.66 0.00e+00 1488.00
IUUC-Loc-052231 Lepisosteus oculatus 81.57 0.00e+00 1451.00
IUUC-Laf-054490 Loxodonta africana 86.37 0.00e+00 1611.00
IUUC-Mcc-055265 Macaca mulatta 93.23 0.00e+00 1729.00
IUUC-Meu-056676 Macropus eugenii 86.49 0.00e+00 729.00
IUUC-Mmr-061633 Microcebus murinus 85.28 0.00e+00 1500.00
IUUC-Mpu-065887 Mustela putorius furo 92.05 0.00e+00 1705.00
IUUC-Mlu-067470 Myotis lucifugus 92.58 0.00e+00 1665.00
IUUC-Nle-069099 Nomascus leucogenys 90.49 0.00e+00 1110.00
IUUC-Ont-071613 Oreochromis niloticus 72.14 0.00e+00 1271.00
IUUC-Oan-073275 Ornithorhynchus anatinus 89.94 0.00e+00 1626.00
IUUC-Ola-087031 Oryzias latipes 67.03 0.00e+00 1170.00
IUUC-Oga-088201 Otolemur garnettii 87.69 0.00e+00 1468.00
IUUC-Oar-089997 Ovis aries 83.41 0.00e+00 1361.00
IUUC-Ptr-091116 Pan troglodytes 93.64 0.00e+00 1737.00
IUUC-Pan-092132 Papio anubis 92.50 0.00e+00 1117.00
IUUC-Psi-093734 Pelodiscus sinensis 88.66 0.00e+00 1525.00
IUUC-Pma-094347 Petromyzon marinus 70.35 0.00e+00 719.00
IUUC-Pfo-096293 Poecilia formosa 69.75 0.00e+00 1196.00
IUUC-Pab-098491 Pongo abelii 90.55 0.00e+00 1636.00
IUUC-Pca-101004 Procavia capensis 82.64 0.00e+00 888.00
IUUC-Pva-102961 Pteropus vampyrus 69.81 0.00e+00 824.00
IUUC-Rno-105005 Rattus norvegicus 98.41 0.00e+00 1771.00
IUUC-Sha-107646 Sarcophilus harrisii 65.73 0.00e+00 944.00
IUUC-Ssc-115428 Sus scrofa 91.06 0.00e+00 1588.00
IUUC-Tgu-116776 Taeniopygia guttata 90.08 0.00e+00 1640.00
IUUC-Tru-118180 Takifugu rubripes 83.05 0.00e+00 826.00
IUUC-Tsy-119468 Tarsius syrichta 87.60 0.00e+00 738.00
IUUC-Tni-120196 Tetraodon nigroviridis 68.62 0.00e+00 1235.00
IUUC-Ttr-128360 Tursiops truncatus 82.16 0.00e+00 946.00
IUUC-Xtr-132956 Xenopus tropicalis 79.96 0.00e+00 1410.00
Created Date 25-Jun-2017

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