iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	1.00e-12	48.5	20	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           e+ W+Cs+CTf+N++ea+kC mC+ ++g+
   Q: 20   EGYWDCSVCTFRNSAEAFKCMMCDVRKGT 48
           677************************95 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.

Protein Sequence
(Fasta)

MGDKKSPTRP KRQPKPASDE GYWDCSVCTF RNSAEAFKCM MCDVRKGTST RKPRPVSQLV 60
AQQVTQQFVP PTQSKKEKKD RVEKDKSEKE AASKKNCHKK TRPRLKNVDR SSAQHLEVTV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTGGGATC CGGCGGCGGC GGCGGCAGCG GCGGCGGCGA CGGCGGCGGC GGCGGCTGCA 60
GCTCGCGGCG CGGCCTTCCC CGCCCCCTCG CCTCCGCGCT TCCGCCGGCC CCTCACCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033774--YAF2_RYBP
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF17219--YAF2_RYBP
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:67057

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001905	Ailuropoda melanoleuca	86.59	8.00e-40	155.00
IUUC-Aca-004478	Anolis carolinensis	88.89	7.00e-56	209.00
IUUC-Ame-011908	Astyanax mexicanus	78.02	7.00e-63	233.00
IUUC-Bta-012681	Bos taurus	84.44	3.00e-40	157.00
IUUC-Cja-018878	Callithrix jacchus	78.43	1.00e-45	176.00
IUUC-Cfa-020696	Canis familiaris	77.55	9.00e-41	159.00
IUUC-Cpo-022486	Cavia porcellus	89.53	4.00e-45	173.00
IUUC-Cho-024392	Choloepus hoffmanni	86.96	1.00e-38	152.00
IUUC-Cin-025723	Ciona intestinalis	46.67	3.00e-21	94.40
IUUC-Dre-028175	Danio rerio	73.45	4.00e-45	173.00
IUUC-Dno-030093	Dasypus novemcinctus	83.70	3.00e-18	83.60
IUUC-Dme-031799	Drosophila melanogaster	50.38	4.00e-28	117.00
IUUC-Ete-032826	Echinops telfairi	57.93	4.00e-30	123.00
IUUC-Eeu-034971	Erinaceus europaeus	86.79	2.00e-37	147.00
IUUC-Fca-036586	Felis catus	85.38	2.00e-17	81.30
IUUC-Gmo-038950	Gadus morhua	70.59	6.00e-52	196.00
IUUC-Gga-040428	Gallus gallus	88.33	1.00e-44	172.00
IUUC-Gac-042503	Gasterosteus aculeatus	74.39	8.00e-51	192.00
IUUC-Ggo-044644	Gorilla gorilla	88.37	1.00e-44	172.00
IUUC-Hsa-046310	Homo sapiens	78.43	1.00e-45	176.00
IUUC-Itr-048494	Ictidomys tridecemlineatus	98.04	4.00e-27	112.00
IUUC-Lch-050130	Latimeria chalumnae	83.33	5.00e-62	229.00
IUUC-Loc-052825	Lepisosteus oculatus	70.83	3.00e-52	197.00
IUUC-Laf-054318	Loxodonta africana	88.89	7.00e-48	182.00
IUUC-Mcc-054885	Macaca mulatta	98.04	3.00e-27	113.00
IUUC-Meu-056465	Macropus eugenii	66.10	2.00e-49	188.00
IUUC-Mga-059338	Meleagris gallopavo	82.28	6.00e-15	72.80
IUUC-Mmr-060766	Microcebus murinus	76.81	3.00e-28	116.00
IUUC-Mdo-062390	Monodelphis domestica	87.22	3.00e-48	184.00
IUUC-Nle-070014	Nomascus leucogenys	78.43	1.00e-45	176.00
IUUC-Ont-071471	Oreochromis niloticus	78.02	4.00e-61	226.00
IUUC-Ocu-073946	Oryctolagus cuniculus	86.47	1.00e-61	228.00
IUUC-Ola-086923	Oryzias latipes	77.90	1.00e-62	231.00
IUUC-Oga-089162	Otolemur garnettii	68.21	1.00e-23	102.00
IUUC-Oar-090289	Ovis aries	60.98	2.00e-23	100.00
IUUC-Ptr-091285	Pan troglodytes	78.43	1.00e-45	176.00
IUUC-Pma-094646	Petromyzon marinus	67.41	3.00e-45	174.00
IUUC-Pfo-097428	Poecilia formosa	71.08	6.00e-45	173.00
IUUC-Pva-102993	Pteropus vampyrus	88.89	2.00e-49	188.00
IUUC-Rno-105835	Rattus norvegicus	90.56	3.00e-53	200.00
IUUC-Sha-107285	Sarcophilus harrisii	87.22	2.00e-48	185.00
IUUC-Tgu-116993	Taeniopygia guttata	87.78	3.00e-44	170.00
IUUC-Tru-118599	Takifugu rubripes	78.03	4.00e-51	193.00
IUUC-Tsy-119409	Tarsius syrichta	83.72	7.00e-17	79.30
IUUC-Tni-120574	Tetraodon nigroviridis	75.27	1.00e-57	215.00
IUUC-Ttr-128187	Tursiops truncatus	86.47	1.00e-40	158.00
IUUC-Vpa-130247	Vicugna pacos	88.30	4.00e-43	167.00
IUUC-Xtr-132148	Xenopus tropicalis	85.56	4.00e-66	243.00
IUUC-Xma-133191	Xiphophorus maculatus	70.27	3.00e-46	177.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence