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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106235
UUCD1 version UUC-SaC-00274
Ensembl Protein ID YGL094C
UniProt Accession P53010; D6VU51; PAN2_YEAST
Genbank Protein ID AAC49152.1; CAA96800.1; DAA08012.1
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID U39204; Z72616; BK006941
Gene Name PAN2; YGL094C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL094C YGL094C YGL094C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 7.30e-14 50.1 515 842
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 11   YmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs...gyeqqDaqEflafl.ldqleeelk 108
           Y N+++Q   +ipe+ +++       + ++  ++ +++ll+ l  lf  +  s+ k  s +++ ++lk++  + +   g  q+  +E+l+ l + +  e+++
   Q: 515  YTNAIIQLYRFIPEMFNFVVG-----CLKD--ENFETTLLTDLGYLFDMMERSHGKICSSSNFQASLKSLTDKRQlenGEPQEHLEEYLESLcIRESIEDFN 609
           9********************.....3322..345789*************************999999988833334666666666666541344445555 PP
   S: 109  keknkpkeeeeeedkselsdeaeekkkkknks.lisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....slqdcLesftkeeelegenk 205
           ++++ +++  ++ ++  ls+  +e+ ++ n++ ++++ F+ +++ ++ c +cd+  ++ +   +ls++  +k+  k++    + q++L  +  + +   +++
   Q: 610  SSESIKRNMPQKFNRFLLSQLIKEEAQTVNHNiTLNQCFGLETEIRTEC-SCDHYDTTVKLLPSLSISGINKTVIKQLnkksNGQNILPYIEYAMKNVTQKN 710
           555555555555555556665666666666651689*************.8***999999999999886655544333555555555533332222222334 PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekqke....kkkYeLiavvvHsG.slssGHYvayvkn 301
             c++c k  + ++++++k+lP vL+l+L+    + ++ +++k+    ef  + ++ + ++ s+ ++  +      kYeL + v     + ++   v+yvk+
   Q: 711  SICPTCGKTETITQECTVKNLPSVLSLELSLLDTEFSNIRSSKNWLTSEFYGSiIKNKAVLRSTASEL-KgtshIFKYELNGYVAKITdNNNETRLVTYVKK 811
           77***************************999666666666666666666555344444444433222.224449*************9************* PP
   S: 302  .....ekgkWllfdDskVtevkeeevleetg 327
                + +kWl f+D  V e++eee l++t 
   Q: 812  ynpkeNCFKWLMFNDYLVVEITEEEALKMTY 842
           877655666*****************99875 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
Protein Sequence
(Fasta)
MNNWQHFFNN PVDLSEHLKK PYFRFDNRDK EITAISFDEK ANLIWSGDSY GCISSYDPTF 60
QLYTRYRGHI GGNSVKDILS HRDGILSISE DSLHFANRRG VTKLNLTSID IAAFSELNTM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106235|DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAATAATT GGCAACATTT CTTCAACAAT CCAGTTGATC TTTCGGAACA TTTGAAGAAG 60
CCATACTTTC GCTTCGATAA TAGGGATAAG GAAATTACAG CGATTAGCTT CGATGAGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106235|DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0006301--P:postreplication repair
KEGG sce:YGL094C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 36.13 4.00e-61 228.00
IUUC-Apl-003500 Anas platyrhynchos 35.59 1.00e-43 169.00
IUUC-Aca-004930 Anolis carolinensis 38.59 7.00e-62 230.00
IUUC-Acl-008214 Aspergillus clavatus 31.96 4.00e-137 480.00
IUUC-Afu-009112 Aspergillus fumigatus 30.68 8.00e-131 459.00
IUUC-Ang-009531 Aspergillus niger 30.56 8.00e-129 452.00
IUUC-Ame-011259 Astyanax mexicanus 38.51 2.00e-59 222.00
IUUC-Bta-012371 Bos taurus 38.55 5.00e-61 227.00
IUUC-Bci-013684 Botrytis cinerea 30.82 1.00e-117 416.00
IUUC-Cja-019297 Callithrix jacchus 38.55 2.00e-60 225.00
IUUC-Cfa-020489 Canis familiaris 38.26 8.00e-61 227.00
IUUC-Cpo-022392 Cavia porcellus 37.92 2.00e-59 222.00
IUUC-Csa-023220 Chlorocebus sabaeus 38.26 3.00e-60 225.00
IUUC-Csv-025841 Ciona savignyi 40.06 1.00e-54 206.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 29.30 4.00e-123 434.00
IUUC-Cne-026932 Cryptococcus neoformans 28.82 6.00e-112 397.00
IUUC-Dre-028482 Danio rerio 37.39 2.00e-59 222.00
IUUC-Dno-029398 Dasypus novemcinctus 38.26 2.00e-60 226.00
IUUC-Dor-030307 Dipodomys ordii 34.02 9.00e-48 183.00
IUUC-Dme-032111 Drosophila melanogaster 37.57 1.00e-57 216.00
IUUC-Eca-033985 Equus caballus 38.26 2.00e-60 226.00
IUUC-Eeu-034928 Erinaceus europaeus 24.63 8.00e-15 74.30
IUUC-Fca-035587 Felis catus 36.39 4.00e-61 228.00
IUUC-Fal-037587 Ficedula albicollis 36.20 6.00e-60 224.00
IUUC-Fso-038133 Fusarium solani 28.43 1.00e-104 372.00
IUUC-Gmo-039076 Gadus morhua 38.78 8.00e-56 210.00
IUUC-Ggr-039957 Gaeumannomyces graminis 29.76 4.00e-119 420.00
IUUC-Gga-040948 Gallus gallus 36.46 9.00e-60 223.00
IUUC-Gac-042396 Gasterosteus aculeatus 38.18 7.00e-58 217.00
IUUC-Ggo-045412 Gorilla gorilla 38.60 7.00e-60 224.00
IUUC-Hsa-046076 Homo sapiens 38.55 3.00e-60 225.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 35.52 3.00e-53 201.00
IUUC-Kpa-049178 Komagataella pastoris 36.50 0.00e+00 648.00
IUUC-Lch-050279 Latimeria chalumnae 38.60 7.00e-60 224.00
IUUC-Loc-052872 Lepisosteus oculatus 38.01 6.00e-58 217.00
IUUC-Lma-052986 Leptosphaeria maculans 31.30 6.00e-144 503.00
IUUC-Laf-054181 Loxodonta africana 37.76 9.00e-61 227.00
IUUC-Mcc-054812 Macaca mulatta 38.55 3.00e-60 225.00
IUUC-Meu-056325 Macropus eugenii 38.78 3.00e-60 225.00
IUUC-Mor-057246 Magnaporthe oryzae 27.53 6.00e-106 377.00
IUUC-Mpo-057464 Magnaporthe poae 29.60 2.00e-121 428.00
IUUC-Mla-058911 Melampsora laricipopulina 30.96 2.00e-73 268.00
IUUC-Mga-059335 Meleagris gallopavo 37.94 2.00e-55 209.00
IUUC-Mvi-060461 Microbotryum violaceum 27.72 1.00e-95 343.00
IUUC-Mmr-060636 Microcebus murinus 38.55 3.00e-60 225.00
IUUC-Mmu-063503 Mus musculus 38.55 4.00e-60 224.00
IUUC-Mpu-066670 Mustela putorius furo 36.13 2.00e-60 226.00
IUUC-Mlu-068119 Myotis lucifugus 38.55 2.00e-61 229.00
IUUC-Nfi-068398 Neosartorya fischeri 31.75 7.00e-139 486.00
IUUC-Ncr-068927 Neurospora crassa 29.12 6.00e-104 370.00
IUUC-Nle-069651 Nomascus leucogenys 37.46 2.00e-60 225.00
IUUC-Opr-070614 Ochotona princeps 38.60 9.00e-60 223.00
IUUC-Ont-072433 Oreochromis niloticus 38.40 2.00e-60 226.00
IUUC-Oan-073283 Ornithorhynchus anatinus 35.39 2.00e-55 208.00
IUUC-Ocu-074401 Oryctolagus cuniculus 38.55 2.00e-60 225.00
IUUC-Ola-087522 Oryzias latipes 36.59 2.00e-61 229.00
IUUC-Oga-088226 Otolemur garnettii 33.48 7.00e-61 227.00
IUUC-Oar-089241 Ovis aries 38.35 3.00e-61 228.00
IUUC-Pan-092297 Papio anubis 38.55 3.00e-60 225.00
IUUC-Psi-094043 Pelodiscus sinensis 37.13 6.00e-49 187.00
IUUC-Pma-094394 Petromyzon marinus 39.05 2.00e-59 222.00
IUUC-Pno-095053 Phaeosphaeria nodorum 31.78 1.00e-125 442.00
IUUC-Ppa-095188 Physcomitrella patens 46.70 3.00e-47 182.00
IUUC-Pfo-097517 Poecilia formosa 36.32 2.00e-60 225.00
IUUC-Pca-100471 Procavia capensis 38.69 1.00e-60 226.00
IUUC-Pva-102805 Pteropus vampyrus 38.55 2.00e-60 226.00
IUUC-Pte-104021 Pyrenophora teres 31.20 1.00e-145 509.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 31.02 2.00e-144 504.00
IUUC-Rno-105471 Rattus norvegicus 38.55 4.00e-60 224.00
IUUC-Sha-106883 Sarcophilus harrisii 38.22 7.00e-61 227.00
IUUC-Spo-108169 Schizosaccharomyces pombe 29.36 2.00e-113 401.00
IUUC-Sar-113323 Sorex araneus 37.01 2.00e-60 225.00
IUUC-Sre-115075 Sporisorium reilianum 46.33 4.00e-52 198.00
IUUC-Ssc-116363 Sus scrofa 38.05 3.00e-61 228.00
IUUC-Tru-118427 Takifugu rubripes 35.56 1.00e-59 223.00
IUUC-Tni-120218 Tetraodon nigroviridis 38.11 8.00e-60 223.00
IUUC-Tre-122177 Trichoderma reesei 29.20 7.00e-125 439.00
IUUC-Tme-127176 Tuber melanosporum 30.99 4.00e-136 477.00
IUUC-Tbe-127641 Tupaia belangeri 46.67 3.00e-10 58.90
IUUC-Ttr-128888 Tursiops truncatus 37.39 6.00e-57 214.00
IUUC-Uma-129361 Ustilago maydis 45.41 8.00e-52 197.00
IUUC-Xtr-132811 Xenopus tropicalis 39.12 5.00e-61 227.00
Created Date 25-Jun-2017

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