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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046012
UUCD1 version UUC-HoS-00232
Ensembl Protein ID ENSP00000449294.1
UniProt Accession Q8N9I9; Q53ZZ2; Q8NAU6; Q8NDS8; DTX3_HUMAN
Genbank Protein ID AAP57520.1; BAC03801.1; BAC04344.1; BAG54727.1; EAW97033.1; AAI14442.1; AAI14499.1; CAD38593.2
Protein Name Probable E3 ubiquitin-protein ligase DTX3; Protein deltex-3; RING finger protein 154; RING-type E3 ubiquitin transferase DTX3
Genbank Nucleotide ID AY225126; AK092085; AK094385; AK128752; CH471054; BC114441; BC114498; AL831941
Gene Name DTX3; RNF154
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000178498.15 ENST00000548804.5 ENSP00000449294.1
ENSG00000178498.15 ENST00000551632.1 ENSP00000448696.1
ENSG00000178498.15 ENST00000550300.1 ENSP00000446996.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 12670957
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0002 23.4 164 202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlC 45
           C+iCl ++++  ++l  C H f++ C+ +        + +  CP C
   Q: 164  CPICLGEIQN-AKTLEkCRHSFCEGCITRA------LQVKKACPMC 202
           ********99.555445**********888......888889**** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Protein Sequence
(Fasta)
MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI DGETSDIYVL 60
QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG ELMGCLALGG GGEHPEMHRA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046012|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CATTTTTGTT TTGGGGAGGA AGGGCAGGGG CTTGCGGATA GAAGGGGGTC AAAGGAACGG 60
TGATTATCAC CTGTGAGGGG AAAGGGGGTG CTGTCCTCCC TCCTTCCCTT TTCCTCAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046012|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
KEGG hsa:196403
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001955 Ailuropoda melanoleuca 89.63 1.00e-146 512.00
IUUC-Aca-004581 Anolis carolinensis 73.71 8.00e-132 462.00
IUUC-Ame-010892 Astyanax mexicanus 45.71 8.00e-77 280.00
IUUC-Bta-013176 Bos taurus 98.56 4.00e-159 553.00
IUUC-Cja-020011 Callithrix jacchus 99.71 3.00e-161 561.00
IUUC-Csa-023491 Chlorocebus sabaeus 99.71 1.00e-160 559.00
IUUC-Dre-027528 Danio rerio 45.33 8.00e-79 287.00
IUUC-Dor-030132 Dipodomys ordii 99.20 4.00e-99 353.00
IUUC-Eca-034031 Equus caballus 99.42 8.00e-161 559.00
IUUC-Fca-035841 Felis catus 90.20 3.00e-150 524.00
IUUC-Gmo-039399 Gadus morhua 66.14 1.00e-74 272.00
IUUC-Gac-041788 Gasterosteus aculeatus 68.25 6.00e-77 280.00
IUUC-Itr-048095 Ictidomys tridecemlineatus 99.38 5.00e-145 506.00
IUUC-Lch-049613 Latimeria chalumnae 49.28 2.00e-90 325.00
IUUC-Loc-052211 Lepisosteus oculatus 66.67 5.00e-74 271.00
IUUC-Laf-054581 Loxodonta africana 97.52 2.00e-136 478.00
IUUC-Mcc-054728 Macaca mulatta 99.71 1.00e-160 559.00
IUUC-Meu-056607 Macropus eugenii 91.49 2.00e-56 213.00
IUUC-Mmr-061590 Microcebus murinus 98.85 8.00e-160 556.00
IUUC-Mmu-063092 Mus musculus 98.56 1.00e-159 555.00
IUUC-Mlu-067304 Myotis lucifugus 98.85 1.00e-159 555.00
IUUC-Nle-069146 Nomascus leucogenys 99.71 4.00e-162 563.00
IUUC-Opr-070349 Ochotona princeps 96.25 9.00e-153 532.00
IUUC-Ont-072659 Oreochromis niloticus 68.78 3.00e-77 281.00
IUUC-Oan-073678 Ornithorhynchus anatinus 59.44 3.00e-62 230.00
IUUC-Ocu-074233 Oryctolagus cuniculus 99.41 1.00e-154 538.00
IUUC-Ola-086410 Oryzias latipes 62.33 3.00e-51 193.00
IUUC-Oga-088601 Otolemur garnettii 98.55 5.00e-159 553.00
IUUC-Oar-089267 Ovis aries 90.49 1.00e-157 548.00
IUUC-Ptr-090762 Pan troglodytes 99.69 1.00e-145 509.00
IUUC-Pan-092025 Papio anubis 100.00 3.00e-161 561.00
IUUC-Pma-094498 Petromyzon marinus 56.15 5.00e-61 227.00
IUUC-Ppa-095323 Physcomitrella patens 49.74 3.00e-49 189.00
IUUC-Pfo-096782 Poecilia formosa 42.44 7.00e-65 241.00
IUUC-Pab-098746 Pongo abelii 96.36 2.00e-93 335.00
IUUC-Pva-102316 Pteropus vampyrus 98.27 2.00e-157 548.00
IUUC-Rno-105615 Rattus norvegicus 98.56 1.00e-159 555.00
IUUC-Sha-107204 Sarcophilus harrisii 95.10 1.00e-155 542.00
IUUC-Ssc-115485 Sus scrofa 99.13 2.00e-157 548.00
IUUC-Tru-118523 Takifugu rubripes 67.91 4.00e-75 274.00
IUUC-Tni-120280 Tetraodon nigroviridis 68.98 7.00e-76 276.00
IUUC-Ttr-128361 Tursiops truncatus 98.27 5.00e-157 546.00
IUUC-Xtr-131966 Xenopus tropicalis 72.65 6.00e-132 463.00
Created Date 25-Jun-2017

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