iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000026965.12	ENSMUST00000028341.10	ENSMUSP00000028341.4
ENSMUSG00000026965.12	ENSMUST00000129300.1	ENSMUSP00000115177.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Cullin	94.50	0.00e+00	1429.00	IUUC-Hsa-045663
E3 adaptor/Cullin RING/APC_C/APC_C	94.50	0.00e+00	1429.00	IUUC-Hsa-045663
E3 adaptor/Cullin RING/APC_C/APC_C	26.23	2.00e-14	76.30	IUUC-Sce-106292

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Protein Sequence
(Fasta)

MEAEGVAVAA AAAAAAAAAT IIASDDCDSR PGQELLVAWN TVSTGLVPPA ALGLASSRTS 60
GAVPPKEEEL RAAVEVLRGH GLHSVLEEWF VEVLQNDLQG NIATEFWNAI ALRENSVDEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTGCGCTCT ACTGGGCGGG TCTGTTTTGT GGACAGTGAT GGAGGCCGAG GGTGTGGCGG 60
TGGCGGCGGC GGCGGCGGCG GCGGCGGCGG CGGCGACAAT TATTGCCTCC GATGACTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014786--APC_su2_C
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2

Pfam

PF08672--ANAPC2
PF00888--Cullin

SMART

SM01013--APC2
SM00182--CULLIN

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0045773--P:positive regulation of axon extension
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:99152

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000110	Aegilops tauschii	36.56	3.00e-87	316.00
IUUC-Aml-001248	Ailuropoda melanoleuca	93.53	0.00e+00	1394.00
IUUC-Atr-002679	Amborella trichopoda	30.70	1.00e-97	351.00
IUUC-Apl-003362	Anas platyrhynchos	71.39	0.00e+00	1067.00
IUUC-Aca-004655	Anolis carolinensis	68.04	0.00e+00	1011.00
IUUC-Aly-006274	Arabidopsis lyrata	35.08	3.00e-94	340.00
IUUC-Ath-007394	Arabidopsis thaliana	34.97	8.00e-95	341.00
IUUC-Ago-007945	Ashbya gossypii	21.14	1.00e-13	71.60
IUUC-Acl-008276	Aspergillus clavatus	34.98	4.00e-69	256.00
IUUC-Afl-008425	Aspergillus flavus	31.71	1.00e-67	251.00
IUUC-Afu-008876	Aspergillus fumigatus	35.08	2.00e-69	257.00
IUUC-Ani-009501	Aspergillus nidulans	33.83	1.00e-71	265.00
IUUC-Ang-009519	Aspergillus niger	32.72	3.00e-65	243.00
IUUC-Aor-009911	Aspergillus oryzae	31.71	2.00e-67	250.00
IUUC-Ate-010350	Aspergillus terreus	37.08	1.00e-59	225.00
IUUC-Ame-011184	Astyanax mexicanus	56.03	0.00e+00	776.00
IUUC-Bgr-011977	Blumeria graminis	32.08	4.00e-67	249.00
IUUC-Bta-013406	Bos taurus	94.13	0.00e+00	1079.00
IUUC-Bci-013817	Botrytis cinerea	33.72	1.00e-63	238.00
IUUC-Bdi-014198	Brachypodium distachyon	37.92	2.00e-88	320.00
IUUC-Bol-015766	Brassica oleracea	35.11	2.00e-93	337.00
IUUC-Bra-017977	Brassica rapa	34.77	3.00e-92	333.00
IUUC-Cel-018129	Caenorhabditis elegans	29.75	1.00e-49	191.00
IUUC-Cja-019940	Callithrix jacchus	94.59	0.00e+00	1464.00
IUUC-Cfa-020113	Canis familiaris	95.17	0.00e+00	1389.00
IUUC-Cpo-021669	Cavia porcellus	95.82	0.00e+00	1483.00
IUUC-Cre-022990	Chlamydomonas reinhardtii	37.98	2.00e-24	107.00
IUUC-Csa-023060	Chlorocebus sabaeus	90.10	0.00e+00	1408.00
IUUC-Cin-025736	Ciona intestinalis	38.70	1.00e-104	374.00
IUUC-Csv-026175	Ciona savignyi	29.89	3.00e-21	94.70
IUUC-Cgl-026442	Colletotrichum gloeosporioides	34.24	1.00e-63	238.00
IUUC-Cne-026902	Cryptococcus neoformans	33.33	2.00e-65	243.00
IUUC-Cme-027318	Cyanidioschyzon merolae	27.79	1.00e-21	98.60
IUUC-Dre-028318	Danio rerio	53.92	0.00e+00	840.00
IUUC-Dno-029026	Dasypus novemcinctus	88.10	0.00e+00	1271.00
IUUC-Dor-031148	Dipodomys ordii	95.26	0.00e+00	1333.00
IUUC-Dse-031458	Dothistroma septosporum	33.21	3.00e-33	137.00
IUUC-Dme-032025	Drosophila melanogaster	37.79	1.00e-140	494.00
IUUC-Ete-033154	Echinops telfairi	88.76	0.00e+00	704.00
IUUC-Eca-033812	Equus caballus	95.76	0.00e+00	1188.00
IUUC-Eeu-035246	Erinaceus europaeus	89.63	8.00e-114	404.00
IUUC-Fca-035890	Felis catus	91.92	0.00e+00	1384.00
IUUC-Fal-037639	Ficedula albicollis	71.58	0.00e+00	1003.00
IUUC-Fox-037792	Fusarium oxysporum	31.50	1.00e-57	218.00
IUUC-Fso-038191	Fusarium solani	30.23	6.00e-58	219.00
IUUC-Gmo-039138	Gadus morhua	60.87	0.00e+00	684.00
IUUC-Ggr-040106	Gaeumannomyces graminis	29.37	2.00e-45	177.00
IUUC-Gga-040327	Gallus gallus	71.03	0.00e+00	1024.00
IUUC-Gac-042053	Gasterosteus aculeatus	55.15	0.00e+00	666.00
IUUC-Gma-043658	Glycine max	29.61	4.00e-96	346.00
IUUC-Ggo-045094	Gorilla gorilla	94.50	0.00e+00	1477.00
IUUC-Hsa-045663	Homo sapiens	94.50	0.00e+00	1478.00
IUUC-Hvu-047677	Hordeum vulgare	40.57	4.00e-77	282.00
IUUC-Itr-047927	Ictidomys tridecemlineatus	95.90	0.00e+00	1468.00
IUUC-Kpa-049177	Komagataella pastoris	32.72	3.00e-67	249.00
IUUC-Lch-049435	Latimeria chalumnae	65.68	0.00e+00	1053.00
IUUC-Lpe-050728	Leersia perrieri	34.38	2.00e-86	313.00
IUUC-Loc-052561	Lepisosteus oculatus	57.41	0.00e+00	862.00
IUUC-Lma-052995	Leptosphaeria maculans	29.81	7.00e-51	196.00
IUUC-Laf-053447	Loxodonta africana	94.20	0.00e+00	1459.00
IUUC-Mcc-054960	Macaca mulatta	94.50	0.00e+00	1476.00
IUUC-Meu-056836	Macropus eugenii	71.48	0.00e+00	1042.00
IUUC-Mor-057155	Magnaporthe oryzae	30.84	2.00e-49	191.00
IUUC-Mpo-057560	Magnaporthe poae	29.12	2.00e-49	191.00
IUUC-Mtr-058784	Medicago truncatula	30.58	2.00e-107	383.00
IUUC-Mla-058965	Melampsora laricipopulina	37.44	2.00e-59	223.00
IUUC-Mga-059511	Meleagris gallopavo	70.28	0.00e+00	1016.00
IUUC-Mvi-060393	Microbotryum violaceum	33.81	9.00e-77	281.00
IUUC-Mmr-061594	Microcebus murinus	95.44	0.00e+00	1473.00
IUUC-Mdo-063009	Monodelphis domestica	74.66	0.00e+00	1095.00
IUUC-Mac-065167	Musa acuminata	29.35	2.00e-93	337.00
IUUC-Mpu-065758	Mustela putorius furo	94.29	0.00e+00	1424.00
IUUC-Nfi-068614	Neosartorya fischeri	34.84	1.00e-68	254.00
IUUC-Ncr-068900	Neurospora crassa	31.28	1.00e-33	138.00
IUUC-Nle-069236	Nomascus leucogenys	87.83	0.00e+00	1311.00
IUUC-Opr-070724	Ochotona princeps	91.28	0.00e+00	784.00
IUUC-Ont-072662	Oreochromis niloticus	50.82	0.00e+00	734.00
IUUC-Oan-073106	Ornithorhynchus anatinus	52.98	2.00e-75	276.00
IUUC-Oba-075268	Oryza barthii	38.38	5.00e-83	302.00
IUUC-Obr-076594	Oryza brachyantha	38.13	5.00e-92	332.00
IUUC-Ogl-077092	Oryza glaberrima	38.52	1.00e-91	330.00
IUUC-Ogu-078791	Oryza glumaepatula	38.25	4.00e-83	303.00
IUUC-Oin-079065	Oryza indica	38.52	1.00e-91	330.00
IUUC-Olo-080300	Oryza longistaminata	38.43	1.00e-81	297.00
IUUC-Ome-081502	Oryza meridionalis	38.59	3.00e-83	303.00
IUUC-Oni-082212	Oryza nivara	38.38	5.00e-83	302.00
IUUC-Opu-083508	Oryza punctata	39.21	7.00e-87	315.00
IUUC-Oru-084815	Oryza rufipogon	38.25	4.00e-83	302.00
IUUC-Osa-085494	Oryza sativa	38.52	1.00e-91	330.00
IUUC-Ola-087495	Oryzias latipes	54.01	0.00e+00	799.00
IUUC-Olu-087578	Ostreococcus lucimarinus	34.48	5.00e-92	332.00
IUUC-Oga-088026	Otolemur garnettii	94.38	0.00e+00	1492.00
IUUC-Oar-089448	Ovis aries	66.40	0.00e+00	851.00
IUUC-Ptr-090626	Pan troglodytes	87.41	0.00e+00	1343.00
IUUC-Pan-092841	Papio anubis	94.50	0.00e+00	1477.00
IUUC-Psi-093519	Pelodiscus sinensis	67.35	3.00e-141	495.00
IUUC-Pno-094923	Phaeosphaeria nodorum	24.90	2.00e-26	114.00
IUUC-Ppa-095741	Physcomitrella patens	40.79	1.00e-63	238.00
IUUC-Pfo-096798	Poecilia formosa	52.17	0.00e+00	763.00
IUUC-Pab-097600	Pongo abelii	94.98	0.00e+00	1480.00
IUUC-Pop-099171	Populus trichocarpa	30.89	2.00e-101	363.00
IUUC-Pca-101085	Procavia capensis	88.40	0.00e+00	1338.00
IUUC-Ppe-101600	Prunus persica	38.85	9.00e-100	358.00
IUUC-Pva-102210	Pteropus vampyrus	93.94	0.00e+00	1449.00
IUUC-Pgr-103279	Puccinia graminis	37.73	3.00e-73	270.00
IUUC-Ptt-103707	Puccinia triticina	35.87	1.00e-60	227.00
IUUC-Pte-104344	Pyrenophora teres	28.36	2.00e-49	191.00
IUUC-Pyt-104781	Pyrenophora triticirepentis	36.99	4.00e-35	143.00
IUUC-Rno-104923	Rattus norvegicus	98.65	0.00e+00	1488.00
IUUC-Sce-106292	Saccharomyces cerevisiae	22.93	1.00e-18	88.60
IUUC-Sha-107256	Sarcophilus harrisii	74.65	0.00e+00	1082.00
IUUC-Sja-107869	Schizosaccharomyces japonicus	34.71	1.00e-69	258.00
IUUC-Spo-108218	Schizosaccharomyces pombe	29.38	8.00e-53	201.00
IUUC-Smo-108710	Selaginella moellendorffii	42.49	1.00e-73	271.00
IUUC-Sit-110252	Setaria italica	37.62	1.00e-86	314.00
IUUC-Sly-111678	Solanum lycopersicum	35.00	2.00e-94	340.00
IUUC-Stu-112740	Solanum tuberosum	30.01	3.00e-97	350.00
IUUC-Sbi-114620	Sorghum bicolor	39.68	7.00e-81	295.00
IUUC-Sre-115165	Sporisorium reilianum	32.71	2.00e-21	97.80
IUUC-Ssc-116411	Sus scrofa	69.57	5.00e-62	229.00
IUUC-Tgu-116996	Taeniopygia guttata	71.14	0.00e+00	1056.00
IUUC-Tru-118128	Takifugu rubripes	57.10	0.00e+00	798.00
IUUC-Tni-120443	Tetraodon nigroviridis	55.84	0.00e+00	756.00
IUUC-Tca-121062	Theobroma cacao	30.38	2.00e-96	347.00
IUUC-Tre-121916	Trichoderma reesei	29.05	3.00e-64	240.00
IUUC-Tvi-122395	Trichoderma virens	27.16	4.00e-56	213.00
IUUC-Tae-124638	Triticum aestivum	38.58	6.00e-89	322.00
IUUC-Tme-126929	Tuber melanosporum	33.88	1.00e-68	254.00
IUUC-Ttr-128180	Tursiops truncatus	87.82	0.00e+00	1345.00
IUUC-Uma-129453	Ustilago maydis	30.39	7.00e-30	125.00
IUUC-Vda-129887	Verticillium dahliae	37.92	2.00e-32	134.00
IUUC-Vvi-130919	Vitis vinifera	34.19	2.00e-97	350.00
IUUC-Xtr-132418	Xenopus tropicalis	67.86	0.00e+00	1059.00
IUUC-Xma-133612	Xiphophorus maculatus	62.17	0.00e+00	690.00
IUUC-Yli-134637	Yarrowia lipolytica	34.90	9.00e-70	258.00
IUUC-Zma-135885	Zea mays	38.03	4.00e-88	319.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence