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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-032126
UUCD1 version UUC-DrM-00154
Ensembl Protein ID FBpp0082511
UniProt Accession Q24572; A0AP04; Q9VFB4; CAF1_DROME
Genbank Protein ID AAB37257.1; CAL26322.1; CAL26323.1; CAL26324.1; CAL26325.1; CAL26330.1; CAL26335.1; CAL26337.1; CAL26338.1; CAL26339.1; CAL26340.1; CAL26341.1; CAL26342.1; AAF55146.1; AAL28956.1
Protein Name Probable histone-binding protein Caf1; Chromatin assembly factor 1 p55 subunit; Nucleosome-remodeling factor 55 kDa subunit; dCAF-1
Genbank Nucleotide ID U62388; AM294392; AM294393; AM294394; AM294395; AM294396; AM294397; AM294398; AM294399; AM294400; AM294401; AM294402; AM294403; AE014297; AY061408
Gene Name Caf1; CG4236
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0263979 FBtr0083052 FBpp0082511
FBgn0263979 FBtr0301845 FBpp0291059
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA
Protein-protein Interaction
IIDPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-38 128.1 276 310
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 276  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 310
           **********96554568*************9875 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.
 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.
Protein Sequence
(Fasta)
MVDRSDNAAE SFDDAVEERV INEEYKIWKK NTPFLYDLVM THALEWPSLT AQWLPDVTKQ 60
DGKDYSVHRL ILGTHTSDEQ NHLLIASVQL PSEDAQFDGS HYDNEKGEFG GFGSVCGKIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032126|E3,WD_repeat|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
GCAGTCGTCT CGACAATCTT TAGCATTGCA TCTCTATCAT CGACGACGCG CTTGCAAAAA 60
AACGAAGGAA ATTAGCCAAT TTCTATTTTG CCCTGACGTT ACGCCGTTTA AAGTGTAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032126|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0033186--C:CAF-1 complex
GO:0035098--C:ESC/E(Z) complex
GO:0035097--C:histone methyltransferase complex
GO:0031523--C:Myb complex
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0016589--C:NURF complex
GO:0005700--C:polytene chromosome
GO:0070822--C:Sin3-type complex
GO:0005667--C:transcription factor complex
GO:0035035--F:histone acetyltransferase binding
GO:0042393--F:histone binding
GO:0042826--F:histone deacetylase binding
GO:0042803--F:protein homodimerization activity
GO:0031497--P:chromatin assembly
GO:0006342--P:chromatin silencing
GO:0048813--P:dendrite morphogenesis
GO:0006281--P:DNA repair
GO:0007307--P:eggshell chorion gene amplification
GO:0016573--P:histone acetylation
GO:0070734--P:histone H3-K27 methylation
GO:0051567--P:histone H3-K9 methylation
GO:0016571--P:histone methylation
GO:0000281--P:mitotic cytokinesis
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048666--P:neuron development
GO:0048812--P:neuron projection morphogenesis
GO:0006334--P:nucleosome assembly
GO:0042766--P:nucleosome mobilization
GO:0016584--P:nucleosome positioning
GO:0008284--P:positive regulation of cell proliferation
GO:0007346--P:regulation of mitotic cell cycle
GO:0007379--P:segment specification
GO:0006351--P:transcription, DNA-templated
KEGG dme:Dmel_CG4236
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 58.60 9.00e-139 485.00
IUUC-Aml-001339 Ailuropoda melanoleuca 91.20 0.00e+00 786.00
IUUC-Atr-003075 Amborella trichopoda 66.59 3.00e-169 587.00
IUUC-Apl-003952 Anas platyrhynchos 91.93 0.00e+00 800.00
IUUC-Aca-004508 Anolis carolinensis 91.04 0.00e+00 801.00
IUUC-Aly-006342 Arabidopsis lyrata 66.25 3.00e-163 567.00
IUUC-Ath-006855 Arabidopsis thaliana 66.50 9.00e-164 568.00
IUUC-Ago-007892 Ashbya gossypii 38.42 2.00e-80 292.00
IUUC-Acl-008163 Aspergillus clavatus 49.76 1.00e-122 432.00
IUUC-Afl-008645 Aspergillus flavus 50.24 2.00e-122 431.00
IUUC-Afu-009091 Aspergillus fumigatus 50.24 3.00e-123 434.00
IUUC-Ani-009478 Aspergillus nidulans 46.59 3.00e-103 367.00
IUUC-Ang-009707 Aspergillus niger 49.27 2.00e-118 418.00
IUUC-Aor-010028 Aspergillus oryzae 50.24 2.00e-122 431.00
IUUC-Ate-010416 Aspergillus terreus 49.76 2.00e-122 431.00
IUUC-Ame-011771 Astyanax mexicanus 89.10 0.00e+00 800.00
IUUC-Bgr-012001 Blumeria graminis 48.47 2.00e-108 384.00
IUUC-Bta-012851 Bos taurus 91.93 0.00e+00 800.00
IUUC-Bci-013815 Botrytis cinerea 49.19 1.00e-125 441.00
IUUC-Bdi-014926 Brachypodium distachyon 64.86 2.00e-160 557.00
IUUC-Bol-015856 Brassica oleracea 67.16 3.00e-163 567.00
IUUC-Bra-016725 Brassica rapa 64.02 2.00e-158 551.00
IUUC-Cel-018587 Caenorhabditis elegans 72.22 0.00e+00 641.00
IUUC-Cja-019884 Callithrix jacchus 91.93 0.00e+00 800.00
IUUC-Cfa-020343 Canis familiaris 91.93 0.00e+00 800.00
IUUC-Cpo-021591 Cavia porcellus 91.93 0.00e+00 800.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 62.35 2.00e-157 547.00
IUUC-Csa-023738 Chlorocebus sabaeus 85.92 0.00e+00 767.00
IUUC-Cho-024506 Choloepus hoffmanni 91.44 0.00e+00 791.00
IUUC-Cin-025589 Ciona intestinalis 86.76 0.00e+00 781.00
IUUC-Csv-026216 Ciona savignyi 86.67 0.00e+00 779.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 46.04 4.00e-115 407.00
IUUC-Cne-026792 Cryptococcus neoformans 54.24 5.00e-134 469.00
IUUC-Cme-027307 Cyanidioschyzon merolae 51.40 3.00e-127 447.00
IUUC-Dre-028742 Danio rerio 91.44 0.00e+00 796.00
IUUC-Dno-029114 Dasypus novemcinctus 91.93 0.00e+00 800.00
IUUC-Dor-030733 Dipodomys ordii 75.18 0.00e+00 643.00
IUUC-Dse-031282 Dothistroma septosporum 45.36 2.00e-101 361.00
IUUC-Ete-032731 Echinops telfairi 91.93 0.00e+00 800.00
IUUC-Eca-033533 Equus caballus 90.71 0.00e+00 783.00
IUUC-Eeu-034644 Erinaceus europaeus 88.69 2.00e-119 421.00
IUUC-Fca-036202 Felis catus 91.93 0.00e+00 800.00
IUUC-Fal-037084 Ficedula albicollis 91.93 0.00e+00 800.00
IUUC-Fox-037974 Fusarium oxysporum 48.81 4.00e-122 430.00
IUUC-Fso-038246 Fusarium solani 46.92 2.00e-109 387.00
IUUC-Gmo-038593 Gadus morhua 90.36 0.00e+00 799.00
IUUC-Ggr-039741 Gaeumannomyces graminis 48.55 7.00e-115 406.00
IUUC-Gga-040396 Gallus gallus 91.93 0.00e+00 800.00
IUUC-Gac-042627 Gasterosteus aculeatus 89.29 0.00e+00 788.00
IUUC-Gma-042791 Glycine max 66.17 7.00e-160 555.00
IUUC-Ggo-045422 Gorilla gorilla 83.50 0.00e+00 702.00
IUUC-Hsa-045683 Homo sapiens 91.93 0.00e+00 800.00
IUUC-Hvu-047457 Hordeum vulgare 65.13 6.00e-75 272.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 91.93 0.00e+00 800.00
IUUC-Kpa-049119 Komagataella pastoris 35.96 2.00e-71 261.00
IUUC-Lch-050545 Latimeria chalumnae 90.12 0.00e+00 800.00
IUUC-Lpe-051337 Leersia perrieri 65.50 2.00e-160 557.00
IUUC-Loc-052473 Lepisosteus oculatus 91.93 0.00e+00 800.00
IUUC-Lma-053275 Leptosphaeria maculans 43.97 1.00e-66 246.00
IUUC-Laf-054114 Loxodonta africana 91.93 0.00e+00 800.00
IUUC-Mcc-055648 Macaca mulatta 91.95 0.00e+00 801.00
IUUC-Meu-056490 Macropus eugenii 91.93 0.00e+00 800.00
IUUC-Mor-056947 Magnaporthe oryzae 49.16 2.00e-115 408.00
IUUC-Mpo-057602 Magnaporthe poae 49.04 2.00e-114 405.00
IUUC-Mtr-057853 Medicago truncatula 66.24 2.00e-159 554.00
IUUC-Mla-058884 Melampsora laricipopulina 51.33 2.00e-125 441.00
IUUC-Mga-059452 Meleagris gallopavo 91.48 0.00e+00 800.00
IUUC-Mvi-060450 Microbotryum violaceum 56.49 6.00e-135 473.00
IUUC-Mmr-060678 Microcebus murinus 92.23 0.00e+00 781.00
IUUC-Mdo-062817 Monodelphis domestica 88.73 0.00e+00 789.00
IUUC-Mmu-063282 Mus musculus 91.93 0.00e+00 800.00
IUUC-Mac-065480 Musa acuminata 65.60 4.00e-160 556.00
IUUC-Mpu-066529 Mustela putorius furo 90.95 0.00e+00 792.00
IUUC-Mlu-068072 Myotis lucifugus 91.93 0.00e+00 800.00
IUUC-Nfi-068374 Neosartorya fischeri 50.24 3.00e-120 424.00
IUUC-Ncr-068794 Neurospora crassa 46.65 8.00e-116 409.00
IUUC-Nle-069577 Nomascus leucogenys 91.93 0.00e+00 800.00
IUUC-Opr-070245 Ochotona princeps 76.77 0.00e+00 626.00
IUUC-Ont-072590 Oreochromis niloticus 89.52 0.00e+00 790.00
IUUC-Oan-072839 Ornithorhynchus anatinus 91.71 0.00e+00 796.00
IUUC-Ocu-074778 Oryctolagus cuniculus 86.16 0.00e+00 768.00
IUUC-Oba-075719 Oryza barthii 54.65 1.00e-132 466.00
IUUC-Obr-076859 Oryza brachyantha 64.46 1.00e-158 551.00
IUUC-Ogl-077920 Oryza glaberrima 65.50 4.00e-160 556.00
IUUC-Ogu-078048 Oryza glumaepatula 54.42 2.00e-131 461.00
IUUC-Oin-079960 Oryza indica 53.75 7.00e-120 423.00
IUUC-Olo-080553 Oryza longistaminata 52.23 1.00e-127 449.00
IUUC-Ome-081835 Oryza meridionalis 65.50 9.00e-161 559.00
IUUC-Oni-082494 Oryza nivara 54.42 7.00e-131 460.00
IUUC-Opu-083913 Oryza punctata 63.00 3.00e-149 520.00
IUUC-Oru-084666 Oryza rufipogon 65.50 4.00e-160 556.00
IUUC-Osa-085884 Oryza sativa 65.50 4.00e-160 556.00
IUUC-Ola-086664 Oryzias latipes 90.24 0.00e+00 800.00
IUUC-Olu-087579 Ostreococcus lucimarinus 63.93 2.00e-146 511.00
IUUC-Oga-088364 Otolemur garnettii 84.67 0.00e+00 730.00
IUUC-Oar-089652 Ovis aries 91.93 0.00e+00 800.00
IUUC-Ptr-091598 Pan troglodytes 86.51 0.00e+00 765.00
IUUC-Pan-092412 Papio anubis 85.92 0.00e+00 767.00
IUUC-Psi-093300 Pelodiscus sinensis 91.58 0.00e+00 740.00
IUUC-Pma-094307 Petromyzon marinus 87.29 0.00e+00 779.00
IUUC-Pno-095153 Phaeosphaeria nodorum 47.68 2.00e-106 378.00
IUUC-Ppa-095800 Physcomitrella patens 67.24 1.00e-168 585.00
IUUC-Pfo-097240 Poecilia formosa 89.47 0.00e+00 794.00
IUUC-Pab-097697 Pongo abelii 91.93 0.00e+00 800.00
IUUC-Pop-099709 Populus trichocarpa 66.10 3.00e-165 573.00
IUUC-Pca-100642 Procavia capensis 82.41 0.00e+00 686.00
IUUC-Ppe-101212 Prunus persica 66.09 4.00e-163 566.00
IUUC-Pva-102253 Pteropus vampyrus 91.93 0.00e+00 800.00
IUUC-Pgr-103441 Puccinia graminis 50.59 2.00e-121 427.00
IUUC-Pte-104332 Pyrenophora teres 47.93 2.00e-109 387.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 48.14 4.00e-109 387.00
IUUC-Rno-105678 Rattus norvegicus 91.93 0.00e+00 800.00
IUUC-Sce-106364 Saccharomyces cerevisiae 36.20 3.00e-69 254.00
IUUC-Sha-106663 Sarcophilus harrisii 91.93 0.00e+00 800.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 46.65 3.00e-106 377.00
IUUC-Spo-108145 Schizosaccharomyces pombe 50.24 2.00e-117 415.00
IUUC-Smo-109159 Selaginella moellendorffii 64.96 6.00e-162 562.00
IUUC-Sit-110144 Setaria italica 63.92 8.00e-153 532.00
IUUC-Sly-111680 Solanum lycopersicum 66.25 4.00e-163 566.00
IUUC-Stu-111931 Solanum tuberosum 66.25 4.00e-162 563.00
IUUC-Sar-113236 Sorex araneus 79.23 0.00e+00 675.00
IUUC-Sbi-114637 Sorghum bicolor 64.16 1.00e-159 555.00
IUUC-Sre-114980 Sporisorium reilianum 53.68 3.00e-136 477.00
IUUC-Ssc-116352 Sus scrofa 86.75 0.00e+00 767.00
IUUC-Tgu-116925 Taeniopygia guttata 91.04 0.00e+00 801.00
IUUC-Tru-117549 Takifugu rubripes 91.48 0.00e+00 790.00
IUUC-Tsy-118854 Tarsius syrichta 86.51 0.00e+00 764.00
IUUC-Tni-120398 Tetraodon nigroviridis 91.24 0.00e+00 793.00
IUUC-Tca-121841 Theobroma cacao 66.34 4.00e-164 569.00
IUUC-Tre-122190 Trichoderma reesei 48.57 6.00e-114 403.00
IUUC-Tvi-122304 Trichoderma virens 48.10 4.00e-122 430.00
IUUC-Tae-124648 Triticum aestivum 64.37 1.00e-152 531.00
IUUC-Tur-126850 Triticum urartu 61.06 9.00e-115 405.00
IUUC-Tme-126949 Tuber melanosporum 53.62 3.00e-131 460.00
IUUC-Tbe-128010 Tupaia belangeri 76.14 0.00e+00 663.00
IUUC-Ttr-128558 Tursiops truncatus 78.07 0.00e+00 673.00
IUUC-Uma-129424 Ustilago maydis 53.68 6.00e-137 479.00
IUUC-Vda-129873 Verticillium dahliae 47.62 8.00e-120 422.00
IUUC-Vpa-130079 Vicugna pacos 91.44 0.00e+00 794.00
IUUC-Vvi-131585 Vitis vinifera 65.85 2.00e-162 564.00
IUUC-Xtr-132005 Xenopus tropicalis 88.28 0.00e+00 788.00
IUUC-Xma-133485 Xiphophorus maculatus 89.26 0.00e+00 789.00
IUUC-Yli-134334 Yarrowia lipolytica 38.21 3.00e-81 295.00
IUUC-Zma-135710 Zea mays 63.92 1.00e-153 535.00
Created Date 25-Jun-2017

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