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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064023
Ensembl Protein ID ENSMUSP00000099368.3
UniProt Accession Q60598; Q3UGC2; SRC8_MOUSE
Genbank Protein ID AAA19689.1; BAE27485.1; BAE28287.1; BAE40543.1; EDL18251.1
Protein Name Src substrate cortactin
Genbank Nucleotide ID U03184; AK146856; AK148010; AK168699; CH466531
Gene Name Cttn; Ems1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031078.15 ENSMUST00000033407.12 ENSMUSP00000033407.6
ENSMUSG00000031078.15 ENSMUST00000103079.3 ENSMUSP00000099368.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.60e-12 48.3 494 543
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++lydy+a+ dde ++   d+++ i  e  d gW++g    +g+ GlfP+n+ve
   Q: 494  IALYDYQAAGDDEISFDPDDIITNI--EMIDDGWWRG--VCKGRYGLFPANYVE 543
           79***********************..9*********..7************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity).
 Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity).
Protein Sequence
(Fasta)
MWKASAGHAV SITQDDGGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE 60
NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDRSAV GHEYQSKLSK HCSQVDSVRG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064023|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTAGATCCAT GCGTGGGTAG AGAGTTGCAG GGTGGATACA TGGTTGGAAG CTGGGTTGAG 60
GGTGAATGTG TGTTGGACAG GGCTTGACGG GTGTTTCTAA ATCGGATCTC CGCAGCTGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064023|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0832--Ubl conjugation
Interpro

IPR015503--Cortactin
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain
PROSITE

PS51090--CORTACTIN
PS50002--SH3
Pfam

PF02218--HS1_rep
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0005884--C:actin filament
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005913--C:cell-cell adherens junction
GO:0005905--C:clathrin-coated pit
GO:0030863--C:cortical cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0030027--C:lamellipodium
GO:1990023--C:mitotic spindle midzone
GO:0005886--C:plasma membrane
GO:0002102--C:podosome
GO:0001726--C:ruffle
GO:0008076--C:voltage-gated potassium channel complex
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0005522--F:profilin binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0030041--P:actin filament polymerization
GO:0048870--P:cell motility
GO:0097062--P:dendritic spine maintenance
GO:0048041--P:focal adhesion assembly
GO:0006886--P:intracellular protein transport
GO:0097581--P:lamellipodium organization
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0048812--P:neuron projection morphogenesis
GO:0030838--P:positive regulation of actin filament polymerization
GO:0045987--P:positive regulation of smooth muscle contraction
GO:0006898--P:receptor-mediated endocytosis
GO:0030516--P:regulation of axon extension
GO:1903146--P:regulation of mitophagy
GO:0006930--P:substrate-dependent cell migration, cell extension
KEGG mmu:13043
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002064 Ailuropoda melanoleuca 89.72 0.00e+00 919.00
IUUC-Apl-003745 Anas platyrhynchos 84.12 0.00e+00 786.00
IUUC-Aca-004438 Anolis carolinensis 79.04 0.00e+00 856.00
IUUC-Ame-011504 Astyanax mexicanus 56.35 3.00e-97 349.00
IUUC-Bgr-012041 Blumeria graminis 57.89 9.00e-16 79.00
IUUC-Bta-013563 Bos taurus 88.64 0.00e+00 884.00
IUUC-Bci-013690 Botrytis cinerea 58.82 5.00e-12 66.60
IUUC-Cel-018639 Caenorhabditis elegans 42.96 2.00e-20 94.40
IUUC-Cfa-020718 Canis familiaris 86.11 0.00e+00 912.00
IUUC-Cpo-022303 Cavia porcellus 89.64 0.00e+00 1001.00
IUUC-Csa-023431 Chlorocebus sabaeus 92.00 0.00e+00 952.00
IUUC-Cin-025677 Ciona intestinalis 61.93 3.00e-119 422.00
IUUC-Csv-026140 Ciona savignyi 64.00 5.00e-109 388.00
IUUC-Dre-028012 Danio rerio 63.74 5.00e-178 617.00
IUUC-Dno-029332 Dasypus novemcinctus 81.49 0.00e+00 763.00
IUUC-Dse-031182 Dothistroma septosporum 33.58 3.00e-11 63.90
IUUC-Dme-031931 Drosophila melanogaster 62.17 1.00e-73 270.00
IUUC-Eca-033801 Equus caballus 90.69 0.00e+00 912.00
IUUC-Fca-035633 Felis catus 87.42 0.00e+00 750.00
IUUC-Fal-036775 Ficedula albicollis 82.85 0.00e+00 792.00
IUUC-Fox-037778 Fusarium oxysporum 59.65 1.00e-14 75.10
IUUC-Gmo-038507 Gadus morhua 70.69 4.00e-20 92.80
IUUC-Gga-040568 Gallus gallus 83.75 0.00e+00 807.00
IUUC-Gac-042253 Gasterosteus aculeatus 56.10 2.00e-114 405.00
IUUC-Hsa-046818 Homo sapiens 92.18 0.00e+00 952.00
IUUC-Itr-048833 Ictidomys tridecemlineatus 87.25 0.00e+00 857.00
IUUC-Lch-050199 Latimeria chalumnae 71.39 1.00e-145 509.00
IUUC-Loc-052855 Lepisosteus oculatus 74.79 4.00e-152 531.00
IUUC-Laf-053866 Loxodonta africana 88.57 0.00e+00 959.00
IUUC-Mcc-055515 Macaca mulatta 92.18 0.00e+00 928.00
IUUC-Mpo-057325 Magnaporthe poae 50.98 3.00e-10 57.80
IUUC-Mga-059791 Meleagris gallopavo 83.24 0.00e+00 800.00
IUUC-Mmr-061147 Microcebus murinus 90.94 0.00e+00 872.00
IUUC-Mdo-062660 Monodelphis domestica 62.03 3.00e-177 615.00
IUUC-Mpu-065867 Mustela putorius furo 80.92 0.00e+00 790.00
IUUC-Mlu-067704 Myotis lucifugus 82.49 0.00e+00 780.00
IUUC-Ont-071873 Oreochromis niloticus 79.55 6.00e-165 573.00
IUUC-Oan-073528 Ornithorhynchus anatinus 81.80 2.00e-161 562.00
IUUC-Oga-088028 Otolemur garnettii 90.00 0.00e+00 924.00
IUUC-Oar-090203 Ovis aries 88.05 0.00e+00 809.00
IUUC-Pan-092594 Papio anubis 87.84 0.00e+00 865.00
IUUC-Psi-093389 Pelodiscus sinensis 81.77 0.00e+00 804.00
IUUC-Pma-094161 Petromyzon marinus 46.03 6.00e-84 305.00
IUUC-Pfo-096269 Poecilia formosa 58.95 8.00e-105 374.00
IUUC-Pab-097913 Pongo abelii 85.09 0.00e+00 820.00
IUUC-Rno-105489 Rattus norvegicus 97.44 0.00e+00 947.00
IUUC-Sha-107308 Sarcophilus harrisii 70.14 0.00e+00 686.00
IUUC-Sja-107956 Schizosaccharomyces japonicus 55.17 1.00e-14 75.10
IUUC-Tgu-117049 Taeniopygia guttata 76.78 0.00e+00 714.00
IUUC-Tru-118718 Takifugu rubripes 75.14 3.00e-156 545.00
IUUC-Tni-120535 Tetraodon nigroviridis 55.64 8.00e-154 536.00
IUUC-Tre-122167 Trichoderma reesei 59.18 2.00e-11 65.10
IUUC-Tvi-122614 Trichoderma virens 59.18 1.00e-11 65.50
IUUC-Vda-129766 Verticillium dahliae 57.89 2.00e-13 71.60
IUUC-Xtr-131797 Xenopus tropicalis 64.71 0.00e+00 652.00
Created Date 25-Jun-2017

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