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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046159
Ensembl Protein ID ENSP00000366746.3
UniProt Accession Q92783; B0YJ99; D3DRU5; Q8N6D9; STAM1_HUMAN
Genbank Protein ID AAC50734.1; ACA06077.1; ACA06078.1; EAW86207.1; EAW86209.1; AAH30586.1
Protein Name Signal transducing adapter molecule 1
Genbank Nucleotide ID U43899; EF445033; EF445033; CH471072; CH471072; BC030586
Gene Name STAM; STAM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136738.14 ENST00000377524.7 ENSP00000366746.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 12750381; 15640163; 17078930; 19111546
UBD/Alpha-Helix/VHS VHS 15640163; 17078930; 19111546
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 4.20e-55 187.0 16 143
UBD/Alpha-Helix/UIM 0.0021 19.5 171 189
UBD/SH3 8.70e-17 62.5 213 265
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepkvie 92
           atse++t+edw lil+icd+++++++g+kd+lr++++r+n+k+phva++aLtlL++cvsnCgk+fh+ev+s+d+++e++++l n+ +pkv+e
   Q: 16   ATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL-NKGHPKVCE 106
           799*******************************************************************************.9******** PP
   S: 93   KlkalivsWadelknepalslivaliktlkeeGlefp 129
           Klkal+v+W+de+kn+p+lsli+a+ik+lke+G++fp
   Q: 107  KLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFP 143
           ************************************8 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+e+L++A++lSl+E+++
   Q: 171  KEEEDLAKAIELSLKEQRQ 189
           69**************987 PP
   

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +kv+++yd+ea++d+eLt+k+G++++v+  ++ d +W+kg  e+++  GlfP+nFv+
   Q: 213  RKVRAIYDFEAAEDNELTFKAGEIITVL--DDSDPNWWKG--ETHQGIGLFPSNFVT 265
           699*************************..99********..9************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB.
 Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB.
Protein Sequence
(Fasta)
MPLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH 60
VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046159|UBD,UIM;UBD,VHS;UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCTCCGCGC GGGGGCTTCC TCGGCTCCTT GCTGTTGCCG CCGCCGCAGC TGCTGCCGCG 60
GTTGGTGGGG TTGGGTGAGA GGAGGAGCTG TCGCGGACCC TGTAGAGTCG GTCTCTGTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046159|UBD,UIM;UBD,VHS;UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom
PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS
Pfam

PF00018--SH3_1
PF02809--UIM
PF00790--VHS
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00288--VHS
Gene Ontology

GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0033565--C:ESCRT-0 complex
GO:0005070--F:SH3/SH2 adaptor activity
GO:0016197--P:endosomal transport
GO:0006886--P:intracellular protein transport
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0036258--P:multivesicular body assembly
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:1903543--P:positive regulation of exosomal secretion
GO:0016579--P:protein deubiquitination
GO:1903551--P:regulation of extracellular exosome assembly
GO:0007165--P:signal transduction
KEGG hsa:8027
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002392 Ailuropoda melanoleuca 94.59 0.00e+00 935.00
IUUC-Apl-003463 Anas platyrhynchos 87.52 0.00e+00 876.00
IUUC-Aca-005116 Anolis carolinensis 84.36 0.00e+00 855.00
IUUC-Ame-011220 Astyanax mexicanus 73.62 0.00e+00 755.00
IUUC-Bta-013368 Bos taurus 92.44 0.00e+00 905.00
IUUC-Cel-018461 Caenorhabditis elegans 33.16 4.00e-52 198.00
IUUC-Cja-019133 Callithrix jacchus 98.45 0.00e+00 956.00
IUUC-Cfa-020800 Canis familiaris 95.17 0.00e+00 932.00
IUUC-Cpo-021685 Cavia porcellus 91.93 0.00e+00 915.00
IUUC-Csa-023325 Chlorocebus sabaeus 99.03 0.00e+00 967.00
IUUC-Cho-024556 Choloepus hoffmanni 88.74 0.00e+00 804.00
IUUC-Cin-025766 Ciona intestinalis 39.10 7.00e-52 197.00
IUUC-Csv-026035 Ciona savignyi 40.15 1.00e-47 182.00
IUUC-Cgl-026648 Colletotrichum gloeosporioides 27.87 3.00e-40 159.00
IUUC-Dre-028379 Danio rerio 80.49 0.00e+00 757.00
IUUC-Dno-029288 Dasypus novemcinctus 87.98 0.00e+00 876.00
IUUC-Dor-030515 Dipodomys ordii 86.49 0.00e+00 782.00
IUUC-Dme-031987 Drosophila melanogaster 45.41 6.00e-99 355.00
IUUC-Ete-032804 Echinops telfairi 77.33 0.00e+00 681.00
IUUC-Eca-033520 Equus caballus 92.73 0.00e+00 872.00
IUUC-Eeu-034820 Erinaceus europaeus 91.67 0.00e+00 837.00
IUUC-Fca-035914 Felis catus 95.53 0.00e+00 934.00
IUUC-Fal-037355 Ficedula albicollis 89.39 0.00e+00 831.00
IUUC-Fox-037748 Fusarium oxysporum 31.56 8.00e-40 158.00
IUUC-Fso-038126 Fusarium solani 28.11 3.00e-41 163.00
IUUC-Gmo-039628 Gadus morhua 82.99 0.00e+00 678.00
IUUC-Gga-041110 Gallus gallus 87.64 0.00e+00 907.00
IUUC-Gac-042301 Gasterosteus aculeatus 84.82 0.00e+00 740.00
IUUC-Ggo-044963 Gorilla gorilla 99.81 0.00e+00 973.00
IUUC-Itr-048016 Ictidomys tridecemlineatus 92.78 0.00e+00 640.00
IUUC-Kpa-049200 Komagataella pastoris 24.52 2.00e-26 113.00
IUUC-Lch-050447 Latimeria chalumnae 79.65 0.00e+00 813.00
IUUC-Loc-052761 Lepisosteus oculatus 77.26 0.00e+00 758.00
IUUC-Lma-053287 Leptosphaeria maculans 28.13 7.00e-37 149.00
IUUC-Laf-053662 Loxodonta africana 91.55 0.00e+00 906.00
IUUC-Mcc-055110 Macaca mulatta 99.03 0.00e+00 966.00
IUUC-Meu-056371 Macropus eugenii 74.60 0.00e+00 707.00
IUUC-Mga-060117 Meleagris gallopavo 85.27 0.00e+00 878.00
IUUC-Mmr-061413 Microcebus murinus 94.59 0.00e+00 915.00
IUUC-Mdo-061951 Monodelphis domestica 92.31 0.00e+00 925.00
IUUC-Mmu-063771 Mus musculus 89.73 0.00e+00 940.00
IUUC-Mpu-066335 Mustela putorius furo 89.80 0.00e+00 838.00
IUUC-Mlu-067740 Myotis lucifugus 93.08 0.00e+00 884.00
IUUC-Nle-069083 Nomascus leucogenys 99.03 0.00e+00 967.00
IUUC-Opr-071162 Ochotona princeps 77.85 2.00e-147 515.00
IUUC-Ont-072360 Oreochromis niloticus 74.51 0.00e+00 758.00
IUUC-Oan-073093 Ornithorhynchus anatinus 85.55 0.00e+00 822.00
IUUC-Ocu-074641 Oryctolagus cuniculus 95.07 0.00e+00 902.00
IUUC-Ola-087487 Oryzias latipes 78.95 0.00e+00 714.00
IUUC-Oga-088551 Otolemur garnettii 95.17 0.00e+00 971.00
IUUC-Oar-089972 Ovis aries 92.44 0.00e+00 905.00
IUUC-Ptr-090672 Pan troglodytes 99.81 0.00e+00 973.00
IUUC-Pan-092407 Papio anubis 99.58 0.00e+00 924.00
IUUC-Psi-092953 Pelodiscus sinensis 84.94 0.00e+00 859.00
IUUC-Pma-094312 Petromyzon marinus 71.12 2.00e-160 558.00
IUUC-Pfo-096030 Poecilia formosa 82.80 0.00e+00 731.00
IUUC-Pab-097691 Pongo abelii 99.61 0.00e+00 971.00
IUUC-Pca-100396 Procavia capensis 82.97 0.00e+00 657.00
IUUC-Pva-103120 Pteropus vampyrus 94.98 0.00e+00 917.00
IUUC-Pgr-103679 Puccinia graminis 39.84 3.00e-20 94.00
IUUC-Ptt-103709 Puccinia triticina 39.84 1.00e-20 95.10
IUUC-Pte-104251 Pyrenophora teres 29.51 5.00e-39 155.00
IUUC-Pyt-104694 Pyrenophora triticirepentis 29.63 7.00e-40 158.00
IUUC-Rno-105982 Rattus norvegicus 89.71 0.00e+00 921.00
IUUC-Sha-106927 Sarcophilus harrisii 89.81 0.00e+00 947.00
IUUC-Sar-113551 Sorex araneus 96.15 0.00e+00 882.00
IUUC-Ssc-115322 Sus scrofa 97.12 0.00e+00 807.00
IUUC-Tgu-116550 Taeniopygia guttata 86.49 0.00e+00 892.00
IUUC-Tru-118646 Takifugu rubripes 83.11 0.00e+00 721.00
IUUC-Tsy-118874 Tarsius syrichta 95.17 0.00e+00 925.00
IUUC-Tni-120235 Tetraodon nigroviridis 81.92 0.00e+00 721.00
IUUC-Tvi-122365 Trichoderma virens 28.68 2.00e-40 160.00
IUUC-Tme-127104 Tuber melanosporum 27.54 3.00e-36 146.00
IUUC-Tbe-127233 Tupaia belangeri 90.15 7.00e-164 570.00
IUUC-Ttr-129298 Tursiops truncatus 86.05 0.00e+00 827.00
IUUC-Vpa-130071 Vicugna pacos 87.65 0.00e+00 816.00
IUUC-Xtr-131863 Xenopus tropicalis 80.67 0.00e+00 793.00
Created Date 25-Jun-2017

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