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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046021
UUCD1 version UUC-HoS-00330
Ensembl Protein ID ENSP00000253237.4
UniProt Accession Q9BQ67; A0MNN5; Q8TF59; GRWD1_HUMAN
Genbank Protein ID AAK17998.1; ABK41104.1; EAW52347.1; AAH02440.1; BAB85528.1
Protein Name Glutamate-rich WD repeat-containing protein 1
Genbank Nucleotide ID AF337808; EF011614; AC008403; BC002440; AB075822
Gene Name GRWD1; GRWD; KIAA1942; WDR28
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000105447.12 ENST00000253237.9 ENSP00000253237.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.80e-24 84.8 259 294
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtg 33
           gHt sv +l++  ++ t ++s+s D +i++WD+r  
   Q: 259  GHTRSVEDLQWspTEnTVFASCSADASIRIWDIRAA 294
           8***********644799**************9865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).
 Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).
Protein Sequence
(Fasta)
MAARKGRRRT CETGEPMEAE SGDTSSEGPA QVYLPGRGPP LREGEELVMD EEAYVLYHRA 60
QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS NRLMMLRMHN LHGTKPPPSE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046021|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTACCGCGA GGAACAGCGC CCAAAGTCAC GCGAAGATGC AGTTTCTCCG TATCCGCAGG 60
CTTCTTTCGC TGGCGCCATT ACCTGAGTTC TCCTCCAGCG TTTCCGCACC CTCTCCGATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046021|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003688--F:DNA replication origin binding
GO:0042393--F:histone binding
GO:0003723--F:RNA binding
GO:0006260--P:DNA replication
GO:0006334--P:nucleosome assembly
GO:0006337--P:nucleosome disassembly
KEGG hsa:83743
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000677 Aegilops tauschii 42.99 1.00e-79 290.00
IUUC-Aml-002309 Ailuropoda melanoleuca 94.41 0.00e+00 842.00
IUUC-Atr-002461 Amborella trichopoda 45.69 2.00e-94 339.00
IUUC-Aca-004760 Anolis carolinensis 72.35 7.00e-172 597.00
IUUC-Aly-005405 Arabidopsis lyrata 41.91 4.00e-87 315.00
IUUC-Ath-007178 Arabidopsis thaliana 42.50 5.00e-88 318.00
IUUC-Ago-007735 Ashbya gossypii 35.44 4.00e-69 255.00
IUUC-Acl-008294 Aspergillus clavatus 40.55 2.00e-78 286.00
IUUC-Afl-008486 Aspergillus flavus 40.27 9.00e-77 281.00
IUUC-Afu-009019 Aspergillus fumigatus 40.09 4.00e-79 288.00
IUUC-Ani-009465 Aspergillus nidulans 40.83 1.00e-76 280.00
IUUC-Ang-009641 Aspergillus niger 40.27 3.00e-75 275.00
IUUC-Ate-010426 Aspergillus terreus 41.10 9.00e-79 287.00
IUUC-Ame-010856 Astyanax mexicanus 61.16 6.00e-149 520.00
IUUC-Bgr-012258 Blumeria graminis 38.93 5.00e-65 241.00
IUUC-Bta-012437 Bos taurus 93.05 0.00e+00 833.00
IUUC-Bci-013647 Botrytis cinerea 40.92 6.00e-77 281.00
IUUC-Bdi-014728 Brachypodium distachyon 46.08 2.00e-97 349.00
IUUC-Bol-015126 Brassica oleracea 41.50 6.00e-87 314.00
IUUC-Bra-017677 Brassica rapa 46.94 3.00e-42 165.00
IUUC-Cel-018454 Caenorhabditis elegans 44.68 5.00e-106 378.00
IUUC-Cja-018859 Callithrix jacchus 95.29 0.00e+00 836.00
IUUC-Cfa-020912 Canis familiaris 90.81 0.00e+00 821.00
IUUC-Cpo-021368 Cavia porcellus 91.48 0.00e+00 811.00
IUUC-Cre-022850 Chlamydomonas reinhardtii 36.95 2.00e-62 233.00
IUUC-Csa-023599 Chlorocebus sabaeus 97.98 0.00e+00 868.00
IUUC-Cin-025718 Ciona intestinalis 56.59 1.00e-142 499.00
IUUC-Csv-025806 Ciona savignyi 56.77 5.00e-107 380.00
IUUC-Cgl-026766 Colletotrichum gloeosporioides 38.73 1.00e-65 243.00
IUUC-Cne-026781 Cryptococcus neoformans 42.49 3.00e-85 309.00
IUUC-Cme-027129 Cyanidioschyzon merolae 34.14 9.00e-45 174.00
IUUC-Dre-028225 Danio rerio 62.50 2.00e-151 529.00
IUUC-Dno-029792 Dasypus novemcinctus 92.46 0.00e+00 808.00
IUUC-Dor-030773 Dipodomys ordii 90.65 9.00e-107 380.00
IUUC-Dse-031289 Dothistroma septosporum 41.24 1.00e-77 283.00
IUUC-Dme-031676 Drosophila melanogaster 52.41 5.00e-132 464.00
IUUC-Ete-033042 Echinops telfairi 87.82 4.00e-69 255.00
IUUC-Eca-033618 Equus caballus 93.74 0.00e+00 811.00
IUUC-Fca-036102 Felis catus 93.75 0.00e+00 837.00
IUUC-Fox-037899 Fusarium oxysporum 39.74 2.00e-80 293.00
IUUC-Fso-038130 Fusarium solani 41.12 1.00e-79 290.00
IUUC-Gmo-038741 Gadus morhua 63.07 2.00e-147 515.00
IUUC-Ggr-040086 Gaeumannomyces graminis 40.00 1.00e-77 283.00
IUUC-Gac-042243 Gasterosteus aculeatus 61.15 3.00e-149 521.00
IUUC-Gma-044177 Glycine max 43.18 3.00e-88 319.00
IUUC-Ggo-044564 Gorilla gorilla 98.21 0.00e+00 875.00
IUUC-Hvu-047721 Hordeum vulgare 44.06 9.00e-91 327.00
IUUC-Itr-048189 Ictidomys tridecemlineatus 92.15 0.00e+00 822.00
IUUC-Kpa-049271 Komagataella pastoris 37.00 1.00e-68 254.00
IUUC-Lch-049974 Latimeria chalumnae 62.90 3.00e-160 558.00
IUUC-Lpe-051388 Leersia perrieri 42.72 9.00e-76 277.00
IUUC-Lma-053010 Leptosphaeria maculans 39.22 1.00e-72 267.00
IUUC-Laf-054058 Loxodonta africana 93.95 0.00e+00 842.00
IUUC-Mcc-055246 Macaca mulatta 97.98 0.00e+00 865.00
IUUC-Meu-056795 Macropus eugenii 78.35 0.00e+00 682.00
IUUC-Mor-057175 Magnaporthe oryzae 39.82 1.00e-77 283.00
IUUC-Mpo-057388 Magnaporthe poae 37.80 2.00e-62 233.00
IUUC-Mtr-057752 Medicago truncatula 43.32 2.00e-84 306.00
IUUC-Mla-058904 Melampsora laricipopulina 40.90 5.00e-81 295.00
IUUC-Mvi-060525 Microbotryum violaceum 40.46 4.00e-75 275.00
IUUC-Mmr-060905 Microcebus murinus 95.07 0.00e+00 846.00
IUUC-Mmu-063428 Mus musculus 91.48 0.00e+00 826.00
IUUC-Mac-065276 Musa acuminata 43.68 9.00e-88 317.00
IUUC-Mpu-066062 Mustela putorius furo 93.51 0.00e+00 837.00
IUUC-Mlu-068115 Myotis lucifugus 94.98 1.00e-122 431.00
IUUC-Nfi-068512 Neosartorya fischeri 40.09 8.00e-76 277.00
IUUC-Ncr-068629 Neurospora crassa 40.63 3.00e-77 282.00
IUUC-Nle-070016 Nomascus leucogenys 93.50 0.00e+00 814.00
IUUC-Ont-072230 Oreochromis niloticus 63.55 2.00e-153 535.00
IUUC-Oan-072759 Ornithorhynchus anatinus 28.99 2.00e-49 190.00
IUUC-Ocu-074511 Oryctolagus cuniculus 92.17 0.00e+00 792.00
IUUC-Oba-075093 Oryza barthii 44.68 9.00e-89 320.00
IUUC-Obr-076130 Oryza brachyantha 45.87 1.00e-97 350.00
IUUC-Ogl-077167 Oryza glaberrima 46.30 5.00e-98 351.00
IUUC-Ogu-078111 Oryza glumaepatula 43.60 9.00e-83 302.00
IUUC-Oin-079162 Oryza indica 44.80 6.00e-90 324.00
IUUC-Olo-080909 Oryza longistaminata 37.40 5.00e-60 225.00
IUUC-Ome-081768 Oryza meridionalis 45.32 1.00e-84 307.00
IUUC-Oni-082453 Oryza nivara 45.00 5.00e-88 319.00
IUUC-Opu-084133 Oryza punctata 43.80 8.00e-77 281.00
IUUC-Oru-085056 Oryza rufipogon 42.98 2.00e-71 263.00
IUUC-Osa-085735 Oryza sativa 46.88 2.00e-97 349.00
IUUC-Ola-087066 Oryzias latipes 61.12 3.00e-147 514.00
IUUC-Olu-087594 Ostreococcus lucimarinus 38.51 1.00e-72 266.00
IUUC-Oga-087974 Otolemur garnettii 92.60 0.00e+00 827.00
IUUC-Oar-089902 Ovis aries 93.50 0.00e+00 835.00
IUUC-Ptr-090469 Pan troglodytes 92.38 0.00e+00 823.00
IUUC-Pan-092858 Papio anubis 98.43 0.00e+00 870.00
IUUC-Psi-094092 Pelodiscus sinensis 58.42 4.00e-96 345.00
IUUC-Pno-094919 Phaeosphaeria nodorum 39.34 1.00e-65 243.00
IUUC-Ppa-095849 Physcomitrella patens 42.17 1.00e-92 333.00
IUUC-Pfo-096535 Poecilia formosa 62.47 2.00e-147 515.00
IUUC-Pab-098478 Pongo abelii 98.65 0.00e+00 876.00
IUUC-Pop-100032 Populus trichocarpa 45.37 5.00e-93 334.00
IUUC-Pca-100403 Procavia capensis 93.10 3.00e-163 566.00
IUUC-Ppe-101997 Prunus persica 46.67 4.00e-96 345.00
IUUC-Pva-102423 Pteropus vampyrus 92.38 0.00e+00 824.00
IUUC-Pgr-103339 Puccinia graminis 42.42 4.00e-84 305.00
IUUC-Ptt-103937 Puccinia triticina 41.29 2.00e-81 296.00
IUUC-Pte-104051 Pyrenophora teres 39.22 2.00e-71 263.00
IUUC-Pyt-104644 Pyrenophora triticirepentis 39.22 1.00e-70 261.00
IUUC-Rno-106118 Rattus norvegicus 91.26 0.00e+00 799.00
IUUC-Sce-106330 Saccharomyces cerevisiae 33.92 4.00e-64 238.00
IUUC-Sha-106564 Sarcophilus harrisii 74.68 2.00e-155 541.00
IUUC-Sja-107969 Schizosaccharomyces japonicus 39.77 9.00e-85 307.00
IUUC-Spo-108351 Schizosaccharomyces pombe 39.25 7.00e-84 304.00
IUUC-Ssl-108452 Sclerotinia sclerotiorum 41.38 7.00e-78 284.00
IUUC-Smo-109619 Selaginella moellendorffii 40.67 5.00e-86 311.00
IUUC-Sit-110719 Setaria italica 45.39 6.00e-91 328.00
IUUC-Sly-111245 Solanum lycopersicum 42.06 7.00e-85 307.00
IUUC-Stu-112645 Solanum tuberosum 43.51 2.00e-92 332.00
IUUC-Sar-113342 Sorex araneus 86.60 0.00e+00 732.00
IUUC-Sbi-114359 Sorghum bicolor 44.93 1.00e-92 333.00
IUUC-Sre-115098 Sporisorium reilianum 46.09 2.00e-91 329.00
IUUC-Ssc-115496 Sus scrofa 92.83 0.00e+00 832.00
IUUC-Tru-117662 Takifugu rubripes 63.55 1.00e-145 509.00
IUUC-Tni-120564 Tetraodon nigroviridis 63.71 3.00e-128 451.00
IUUC-Tca-121710 Theobroma cacao 44.91 1.00e-91 330.00
IUUC-Tre-122239 Trichoderma reesei 41.40 1.00e-78 287.00
IUUC-Tvi-122589 Trichoderma virens 41.16 2.00e-79 289.00
IUUC-Tae-125574 Triticum aestivum 46.51 4.00e-94 338.00
IUUC-Tur-126135 Triticum urartu 45.25 2.00e-74 273.00
IUUC-Tme-127073 Tuber melanosporum 37.70 6.00e-60 225.00
IUUC-Ttr-128383 Tursiops truncatus 91.48 0.00e+00 801.00
IUUC-Uma-129345 Ustilago maydis 45.19 1.00e-94 340.00
IUUC-Vda-129893 Verticillium dahliae 40.31 2.00e-78 286.00
IUUC-Vvi-131067 Vitis vinifera 42.66 2.00e-89 323.00
IUUC-Xtr-132603 Xenopus tropicalis 71.36 2.00e-180 625.00
IUUC-Xma-133149 Xiphophorus maculatus 63.79 2.00e-152 531.00
IUUC-Yli-134459 Yarrowia lipolytica 37.25 2.00e-66 246.00
IUUC-Zma-135548 Zea mays 44.70 5.00e-91 328.00
Created Date 25-Jun-2017

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