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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064070
UUCD1 version UUC-MuM-01093
Ensembl Protein ID ENSMUSP00000096932.3
UniProt Accession P61089; Q16781; Q3TSL6; Q6ZWZ0; Q9DAJ6; UBE2N_MOUSE
Genbank Protein ID CAA71001.1; AAK74128.1; BAB23941.1; BAB24239.1; BAE36659.1; AAH34898.3; AAH67069.1
Protein Name Ubiquitin-conjugating enzyme E2 N; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N
Genbank Nucleotide ID Y09873; AY039837; AK005302; AK005788; AK161968; BC034898; BC067069
Gene Name Ube2n; Blu
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000074781.4 ENSMUST00000099329.3 ENSMUSP00000096932.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E2/UBC 2.10e-47 161.5 7 139
Active Site
Position(s) Description Evidence
87 Glycyl thioester intermediate N/A
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R+ ke+++l ++p++gi+a+p+++ +   ++v+i Gp+d+p+egg+Fkle+ +pe+YP+ +Pkv+f+tki+hPnv++ G++Cl+ilk  
   Q: 7    RIIKETQRLLAEPVPGIKAEPDES-NARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILK-- 92
           899*********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkk 136
           +kWspal++++vllsiq+ll+ pnp++pl +++ae++k+n+++  ++
   Q: 93   DKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIET 139
           ****************************************9976655 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
 The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
Protein Sequence
(Fasta)
MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE 60
EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064070|E2,E2/UBC|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGAGCCGG AGACAAGAGC AGAGGCCGAA CTCGGGATCT GACAAGATGG CCGGGCTGCC 60
CCGCAGGATC ATCAAGGTAA CCGCCCAGGC GGGCTTCGGG CCACTGGCTC TGCTCCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064070|E2,E2/UBC|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0001650--C:fibrillar center
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0031372--C:UBC13-MMS2 complex
GO:0035370--C:UBC13-UEV1A complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0043130--F:ubiquitin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000729--P:DNA double-strand break processing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0016574--P:histone ubiquitination
GO:0045739--P:positive regulation of DNA repair
GO:0031058--P:positive regulation of histone modification
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0033182--P:regulation of histone ubiquitination
GO:0050852--P:T cell receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:93765
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000100 Aegilops tauschii 79.59 3.00e-69 253.00
IUUC-Aml-001889 Ailuropoda melanoleuca 97.24 5.00e-81 292.00
IUUC-Atr-002818 Amborella trichopoda 79.59 1.00e-69 255.00
IUUC-Apl-003469 Anas platyrhynchos 97.95 3.00e-83 299.00
IUUC-Aca-005051 Anolis carolinensis 100.00 2.00e-87 314.00
IUUC-Aly-006258 Arabidopsis lyrata 80.27 2.00e-70 257.00
IUUC-Ath-007639 Arabidopsis thaliana 79.59 6.00e-70 255.00
IUUC-Ago-007837 Ashbya gossypii 75.20 3.00e-54 204.00
IUUC-Acl-008263 Aspergillus clavatus 71.62 1.00e-63 234.00
IUUC-Afl-008733 Aspergillus flavus 72.30 7.00e-64 235.00
IUUC-Afu-008946 Aspergillus fumigatus 71.62 1.00e-63 234.00
IUUC-Ani-009482 Aspergillus nidulans 71.33 4.00e-64 236.00
IUUC-Ang-009678 Aspergillus niger 72.30 1.00e-63 234.00
IUUC-Aor-010025 Aspergillus oryzae 72.30 7.00e-64 235.00
IUUC-Ate-010254 Aspergillus terreus 71.23 2.00e-62 231.00
IUUC-Ame-010742 Astyanax mexicanus 98.03 1.00e-85 308.00
IUUC-Bgr-012156 Blumeria graminis 65.56 2.00e-54 204.00
IUUC-Bta-012636 Bos taurus 100.00 2.00e-87 314.00
IUUC-Bci-013761 Botrytis cinerea 72.48 5.00e-63 233.00
IUUC-Bdi-014796 Brachypodium distachyon 80.27 2.00e-70 257.00
IUUC-Bol-016613 Brassica oleracea 80.27 2.00e-70 257.00
IUUC-Bra-016938 Brassica rapa 80.27 2.00e-70 257.00
IUUC-Cel-018119 Caenorhabditis elegans 88.59 6.00e-75 272.00
IUUC-Cja-019108 Callithrix jacchus 100.00 2.00e-87 314.00
IUUC-Cfa-020561 Canis familiaris 99.34 7.00e-87 311.00
IUUC-Cpo-022280 Cavia porcellus 96.69 1.00e-83 301.00
IUUC-Cre-022978 Chlamydomonas reinhardtii 78.91 4.00e-67 246.00
IUUC-Csa-023860 Chlorocebus sabaeus 92.76 2.00e-80 290.00
IUUC-Cho-024459 Choloepus hoffmanni 100.00 2.00e-87 314.00
IUUC-Cin-025278 Ciona intestinalis 80.27 9.00e-69 252.00
IUUC-Csv-025952 Ciona savignyi 72.97 3.00e-60 223.00
IUUC-Cgl-026752 Colletotrichum gloeosporioides 71.43 2.00e-61 227.00
IUUC-Cne-026809 Cryptococcus neoformans 74.44 7.00e-57 212.00
IUUC-Cme-027100 Cyanidioschyzon merolae 65.77 1.00e-56 211.00
IUUC-Dre-027814 Danio rerio 98.03 1.00e-85 308.00
IUUC-Dno-030059 Dasypus novemcinctus 98.03 1.00e-85 308.00
IUUC-Dor-030269 Dipodomys ordii 100.00 2.00e-73 266.00
IUUC-Dse-031505 Dothistroma septosporum 68.03 1.00e-59 221.00
IUUC-Dme-032097 Drosophila melanogaster 80.13 2.00e-72 264.00
IUUC-Ete-032369 Echinops telfairi 100.00 2.00e-87 314.00
IUUC-Eca-033230 Equus caballus 100.00 2.00e-87 314.00
IUUC-Fca-036161 Felis catus 95.39 3.00e-83 300.00
IUUC-Fal-036781 Ficedula albicollis 96.71 9.00e-85 305.00
IUUC-Fox-037840 Fusarium oxysporum 71.92 1.00e-60 225.00
IUUC-Fso-038118 Fusarium solani 71.92 5.00e-61 226.00
IUUC-Gmo-039561 Gadus morhua 93.42 9.00e-83 298.00
IUUC-Ggr-039807 Gaeumannomyces graminis 72.79 2.00e-62 231.00
IUUC-Gga-041024 Gallus gallus 100.00 2.00e-87 314.00
IUUC-Gac-042450 Gasterosteus aculeatus 92.05 7.00e-81 292.00
IUUC-Gma-043982 Glycine max 80.27 2.00e-70 257.00
IUUC-Ggo-044660 Gorilla gorilla 99.34 8.00e-87 311.00
IUUC-Hsa-045881 Homo sapiens 100.00 2.00e-87 314.00
IUUC-Hvu-047346 Hordeum vulgare 80.27 2.00e-70 257.00
IUUC-Itr-048350 Ictidomys tridecemlineatus 92.11 2.00e-78 284.00
IUUC-Kpa-049285 Komagataella pastoris 70.27 7.00e-63 232.00
IUUC-Lch-050548 Latimeria chalumnae 93.71 7.00e-79 285.00
IUUC-Lpe-051394 Leersia perrieri 80.27 3.00e-70 256.00
IUUC-Loc-052205 Lepisosteus oculatus 98.03 1.00e-85 308.00
IUUC-Lma-053056 Leptosphaeria maculans 72.60 2.00e-62 231.00
IUUC-Laf-053540 Loxodonta africana 100.00 1.00e-81 294.00
IUUC-Mcc-054863 Macaca mulatta 100.00 2.00e-87 314.00
IUUC-Meu-056482 Macropus eugenii 100.00 1.00e-81 294.00
IUUC-Mor-057014 Magnaporthe oryzae 72.60 4.00e-61 226.00
IUUC-Mpo-057586 Magnaporthe poae 72.79 2.00e-62 231.00
IUUC-Mtr-058552 Medicago truncatula 72.05 2.00e-66 244.00
IUUC-Mla-058920 Melampsora laricipopulina 70.07 4.00e-61 226.00
IUUC-Mga-059649 Meleagris gallopavo 96.64 2.00e-82 297.00
IUUC-Mvi-060483 Microbotryum violaceum 75.51 6.00e-65 239.00
IUUC-Mmr-061167 Microcebus murinus 100.00 2.00e-87 314.00
IUUC-Mdo-062701 Monodelphis domestica 100.00 2.00e-87 314.00
IUUC-Mac-064742 Musa acuminata 80.95 6.00e-71 259.00
IUUC-Mpu-066401 Mustela putorius furo 100.00 2.00e-87 313.00
IUUC-Mlu-067229 Myotis lucifugus 98.64 6.00e-83 298.00
IUUC-Nfi-068526 Neosartorya fischeri 71.62 1.00e-63 234.00
IUUC-Ncr-068643 Neurospora crassa 72.11 4.00e-62 229.00
IUUC-Nle-070146 Nomascus leucogenys 100.00 2.00e-87 314.00
IUUC-Opr-070232 Ochotona princeps 78.29 2.00e-63 234.00
IUUC-Ont-072369 Oreochromis niloticus 94.67 2.00e-82 297.00
IUUC-Oan-073174 Ornithorhynchus anatinus 96.05 1.00e-83 301.00
IUUC-Ocu-074712 Oryctolagus cuniculus 100.00 2.00e-87 314.00
IUUC-Oba-075408 Oryza barthii 80.27 3.00e-70 256.00
IUUC-Obr-076881 Oryza brachyantha 80.27 3.00e-70 256.00
IUUC-Ogl-077242 Oryza glaberrima 80.27 3.00e-70 256.00
IUUC-Ogu-078465 Oryza glumaepatula 80.27 3.00e-70 256.00
IUUC-Oin-080035 Oryza indica 80.43 6.00e-66 242.00
IUUC-Olo-080555 Oryza longistaminata 80.27 3.00e-70 256.00
IUUC-Ome-081653 Oryza meridionalis 80.27 3.00e-70 256.00
IUUC-Oni-082400 Oryza nivara 80.27 3.00e-70 256.00
IUUC-Opu-083130 Oryza punctata 80.43 2.00e-65 241.00
IUUC-Oru-084649 Oryza rufipogon 80.27 3.00e-70 256.00
IUUC-Osa-085629 Oryza sativa 80.27 3.00e-70 256.00
IUUC-Ola-087083 Oryzias latipes 94.67 3.00e-82 296.00
IUUC-Olu-087886 Ostreococcus lucimarinus 68.03 1.00e-58 218.00
IUUC-Oga-088983 Otolemur garnettii 96.00 4.00e-83 299.00
IUUC-Oar-090440 Ovis aries 99.34 7.00e-87 311.00
IUUC-Ptr-090572 Pan troglodytes 100.00 2.00e-87 314.00
IUUC-Pan-092503 Papio anubis 98.03 8.00e-86 308.00
IUUC-Psi-093419 Pelodiscus sinensis 100.00 4.00e-78 283.00
IUUC-Pma-094136 Petromyzon marinus 92.86 3.00e-43 165.00
IUUC-Pno-094838 Phaeosphaeria nodorum 72.30 2.00e-63 234.00
IUUC-Ppa-096014 Physcomitrella patens 82.19 8.00e-71 258.00
IUUC-Pfo-096074 Poecilia formosa 95.33 1.00e-82 298.00
IUUC-Pab-097778 Pongo abelii 100.00 2.00e-87 314.00
IUUC-Pop-099707 Populus trichocarpa 80.27 3.00e-70 256.00
IUUC-Pca-100334 Procavia capensis 83.55 5.00e-73 266.00
IUUC-Ppe-101149 Prunus persica 80.27 2.00e-70 257.00
IUUC-Pva-102979 Pteropus vampyrus 100.00 2.00e-87 314.00
IUUC-Pgr-103654 Puccinia graminis 70.75 2.00e-60 224.00
IUUC-Ptt-103752 Puccinia triticina 69.44 4.00e-58 216.00
IUUC-Pte-104137 Pyrenophora teres 71.23 1.00e-61 228.00
IUUC-Pyt-104513 Pyrenophora triticirepentis 71.23 1.00e-61 228.00
IUUC-Rno-105927 Rattus norvegicus 99.34 4.00e-87 312.00
IUUC-Sce-106178 Saccharomyces cerevisiae 70.27 1.00e-61 228.00
IUUC-Sha-107493 Sarcophilus harrisii 100.00 2.00e-87 314.00
IUUC-Sja-107878 Schizosaccharomyces japonicus 66.89 1.00e-57 216.00
IUUC-Spo-108062 Schizosaccharomyces pombe 68.71 9.00e-57 212.00
IUUC-Ssl-108395 Sclerotinia sclerotiorum 70.95 2.00e-61 227.00
IUUC-Smo-109587 Selaginella moellendorffii 74.67 8.00e-64 235.00
IUUC-Sit-110151 Setaria italica 80.27 4.00e-70 257.00
IUUC-Sly-111322 Solanum lycopersicum 80.27 2.00e-70 257.00
IUUC-Stu-112254 Solanum tuberosum 79.59 6.00e-70 256.00
IUUC-Sar-113464 Sorex araneus 100.00 1.00e-81 294.00
IUUC-Sbi-114864 Sorghum bicolor 80.27 9.00e-70 255.00
IUUC-Sre-114927 Sporisorium reilianum 78.08 8.00e-67 245.00
IUUC-Ssc-116096 Sus scrofa 100.00 2.00e-87 314.00
IUUC-Tgu-117266 Taeniopygia guttata 100.00 1.00e-81 294.00
IUUC-Tru-117903 Takifugu rubripes 94.04 1.00e-81 294.00
IUUC-Tsy-118952 Tarsius syrichta 100.00 1.00e-81 294.00
IUUC-Tni-120038 Tetraodon nigroviridis 94.04 1.00e-81 294.00
IUUC-Tca-121752 Theobroma cacao 80.58 8.00e-66 243.00
IUUC-Tre-121979 Trichoderma reesei 73.97 4.00e-62 229.00
IUUC-Tvi-122515 Trichoderma virens 73.29 2.00e-61 227.00
IUUC-Tae-125309 Triticum aestivum 80.27 2.00e-70 257.00
IUUC-Tur-126865 Triticum urartu 79.86 6.00e-65 239.00
IUUC-Tme-127129 Tuber melanosporum 73.97 5.00e-63 232.00
IUUC-Tbe-127846 Tupaia belangeri 100.00 1.00e-81 294.00
IUUC-Ttr-128808 Tursiops truncatus 96.71 6.00e-84 302.00
IUUC-Uma-129548 Ustilago maydis 78.77 2.00e-67 247.00
IUUC-Vda-129810 Verticillium dahliae 71.23 1.00e-60 225.00
IUUC-Vpa-130221 Vicugna pacos 91.37 3.00e-69 253.00
IUUC-Vvi-131416 Vitis vinifera 66.29 2.00e-65 241.00
IUUC-Xtr-132366 Xenopus tropicalis 96.75 2.00e-84 304.00
IUUC-Xma-132986 Xiphophorus maculatus 94.67 3.00e-82 296.00
IUUC-Yli-134605 Yarrowia lipolytica 72.97 1.00e-63 234.00
IUUC-Zma-135587 Zea mays 76.97 6.00e-68 249.00
Created Date 25-Jun-2017

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