iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106486

Ensembl Protein ID

ENSSHAP00000020881.1

UniProt Accession

G3WZM6; G3WZM6_SARHA

Genbank Protein ID

ENSSHAP00000020881

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01079177

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017709.1	ENSSHAT00000021050.1	ENSSHAP00000020881.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-23	81.5	439	477
UBD/Beta-Prp	1.40e-40	139.5	307	477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 439  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 477
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 307  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 394
           5666688889998885.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 395  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 477
           88888888999*********************************9.********************************997443 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MHKQAEIVKR LNAICAQVIP FLSQESSSVS PSASFRTAEK HRNSTDYSSD SKKQKTEEKE 60
ITTRYDSDGE KSDDNLVVDV SNEDPSSPRG SPAHSPRENG LDKTRLLKKD APISPASIAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNGGGGG GAGGGACGCG AAGAGAGACC GGGAGACTTG GGAGTAGGAG 60
GGTTTTCGCT GAGCTCCCTC CATCCCTGCA TTGATGGGGG TTCAAAGTGA GTGAGTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cel-018361	Caenorhabditis elegans	58.99	1.00e-121	430.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence