iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.90e-11	41.7	155	184

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtcla.f.sd.tllvsGsdDgtikvWDl 30
            +++ l+ f  d ++ vsGs D t+ vWDl
   Q: 155  TPISQLSvFkADpRTAVSGSADSTLNVWDL 184
           5677887578565899*************8 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Involved in specific localization of cytoplasmic proteins during the formation of pole plasm. Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte. Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly. May act by regulating the complex that contains the arginine N-methyltransferase csul.

Protein Sequence
(Fasta)

MFPQRSSELY RTPVTHQPPP ALELAGNLEY PNLNIADLNA RLENLSPRLH DCWDSIAIND 60
HNHLALATNR REGRQWWGML FGYGRDQMHH MSVDSANFKL QAEHTVNIVR YAEDDFLLVA 120

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Nucleotide Sequence
(Fasta)

ATGTATTTGG TCTTGCCGGG CTCGTTGCTC TTCCTTGCTG GCCGATTCTC TGTTGTTTTA 60
CGGAATCTTG AGTGAGAGAC GATGTTCCCG CAACGCAGCT CGGAGCTGTA CCGCACTCCG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043186--C:P granule
GO:0045495--C:pole plasm
GO:0007349--P:cellularization
GO:0009880--P:embryonic pattern specification
GO:0007315--P:pole plasm assembly
GO:0019233--P:sensory perception of pain

KEGG

dme:Dmel_CG10728

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002192	Ailuropoda melanoleuca	23.65	2.00e-11	62.80
IUUC-Cfa-021036	Canis familiaris	24.50	1.00e-09	57.00
IUUC-Cpo-022369	Cavia porcellus	22.64	2.00e-10	58.90
IUUC-Meu-056053	Macropus eugenii	27.14	2.00e-13	68.90
IUUC-Opr-071156	Ochotona princeps	23.65	7.00e-10	57.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence