iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-33	113.4	57	87
UBD/Beta-Prp	9.80e-52	176.0	140	345

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH ++v++++f  d ++ v+Gs Dg++ +WD
   Q: 57   GHINKVNSVHFaGDsRHCVTGSLDGKLIIWD 87
           899*********666**************** PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvv 140
           k++++l g e++ ++++f +dg  l+tgs D+ i+ wdl++g  ++ ++gh  ++  ls+sp+ ++ ++Gs d+t+++wd++++   + ++ ghd  v
   Q: 140  KMVKELMGYEGFLSSCRFLDDG-HLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPDMKTYITGSVDKTAKLWDVREEGHKQ-MFFGHDMDV 235
           5689999**************9.8***************************************************************9.********* PP
   S: 141  ncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnde 235
           ++v++hp+g+ ++s+s D+t r++dl+ ++ + +    +  ++   +s +++ +g++l+ g+  g v  wd  +++   tl gh++ ++++ ++pn+ 
   Q: 236  SSVCYHPSGFGFASCSEDQTARMYDLRADQQIAQYeppQ--KNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGM 331
           ***********************************7643..577899999************************************************ PP
   S: 236  rlvsgssDgsiriW 249
            l+s+s D+++r+W
   Q: 332  CLASTSWDQQVRLW 345
           ************** PP

Organism

Drosophila melanogaster

Functional Description
(View)

Belongs to the WD repeat G protein beta family.

Protein Sequence
(Fasta)

MPKIDPETQK LYDEINGMIQ KFKDDQKSKA DCTLADKCGD MGDVPKIRFS SKKILKGHIN 60
KVNSVHFAGD SRHCVTGSLD GKLIIWDTWT ANKVQIIPLR SAWVMTVAFS PSGNFVACGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCAGTTTAT TGTGCGACGC AGTGCGGTTC AAAACTAGAA ACTTTCTTCT GGCAAATATT 60
GCAGCCGTCC TTATATAATT AATGCTCCAT AATGCCGAAA ATTGACCCAG AAACACAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0807--Transducer
KW-0844--Vision
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005834--C:heterotrimeric G-protein complex
GO:0005886--C:plasma membrane
GO:0016028--C:rhabdomere
GO:0046982--F:protein heterodimerization activity
GO:0004871--F:signal transducer activity
GO:0007202--P:activation of phospholipase C activity
GO:0016059--P:deactivation of rhodopsin mediated signaling
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0007602--P:phototransduction
GO:0016056--P:rhodopsin mediated signaling pathway
GO:0007601--P:visual perception

KEGG

dme:Dmel_CG8770

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence