iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA
Protein-protein Interaction
IID	iRefIndex	PINA
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	19081076

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.40e-34	114.6	220	252

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           +++s+t+laf  +dtl+++G++Dg+ikvWDlr+
   Q: 220  TSSSITGLAFqdNDTLISCGAGDGVIKVWDLRR 252
           6899******9777****************985 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex.

Protein Sequence
(Fasta)

MNIYNKLRAR EHGYGNERTY DFALRRLSVA KEDSWRGIAP ANYCPDFNPE PPIFSAKFAN 60
CDGYRHILAI ANEDGKITLQ DTTQRNHQPE EQSLVGPQCH FNAVFDLEWA PGQMRFVSAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTACTTCCCA TCTGAGCACG GTCACACTGC CCAAGAGTCC AGCTGCGTCG TTGAAAAATA 60
TTTTCGATGC CTCGAAGGTT GATTTATTTC AGAGGAAATA GCAGGAAATA AAGTTGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0346--Stress response
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0007049--P:cell cycle
GO:0022008--P:neurogenesis
GO:0016567--P:protein ubiquitination
GO:0051726--P:regulation of cell cycle

KEGG

dme:Dmel_CG11295

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002111	Ailuropoda melanoleuca	42.06	7.00e-82	297.00
IUUC-Atr-003097	Amborella trichopoda	34.88	6.00e-48	184.00
IUUC-Apl-004088	Anas platyrhynchos	43.10	7.00e-79	287.00
IUUC-Aca-004732	Anolis carolinensis	42.24	3.00e-74	272.00
IUUC-Aly-005686	Arabidopsis lyrata	28.41	6.00e-44	171.00
IUUC-Ath-006970	Arabidopsis thaliana	30.23	4.00e-42	164.00
IUUC-Acl-008219	Aspergillus clavatus	22.71	2.00e-20	93.60
IUUC-Afu-008784	Aspergillus fumigatus	23.45	6.00e-22	98.60
IUUC-Ani-009304	Aspergillus nidulans	24.63	1.00e-12	67.80
IUUC-Ang-009842	Aspergillus niger	25.64	9.00e-17	81.30
IUUC-Aor-009883	Aspergillus oryzae	25.27	1.00e-19	90.90
IUUC-Ate-010454	Aspergillus terreus	25.24	8.00e-19	87.40
IUUC-Ame-010949	Astyanax mexicanus	41.08	8.00e-76	277.00
IUUC-Bta-012333	Bos taurus	41.78	2.00e-82	299.00
IUUC-Bdi-014494	Brachypodium distachyon	30.48	6.00e-42	164.00
IUUC-Bol-015301	Brassica oleracea	31.37	8.00e-44	170.00
IUUC-Bra-017384	Brassica rapa	31.08	3.00e-44	172.00
IUUC-Cel-018498	Caenorhabditis elegans	29.19	2.00e-34	139.00
IUUC-Cja-019534	Callithrix jacchus	42.42	1.00e-79	290.00
IUUC-Cfa-020847	Canis familiaris	42.34	1.00e-81	297.00
IUUC-Cpo-021695	Cavia porcellus	42.42	2.00e-81	296.00
IUUC-Cre-022762	Chlamydomonas reinhardtii	30.33	5.00e-35	143.00
IUUC-Csa-023748	Chlorocebus sabaeus	41.87	2.00e-82	299.00
IUUC-Cho-024445	Choloepus hoffmanni	41.13	7.00e-53	201.00
IUUC-Cgl-026664	Colletotrichum gloeosporioides	24.69	4.00e-16	79.30
IUUC-Cne-027008	Cryptococcus neoformans	26.74	3.00e-14	74.30
IUUC-Dre-027536	Danio rerio	41.28	7.00e-75	274.00
IUUC-Dno-030035	Dasypus novemcinctus	42.15	5.00e-81	295.00
IUUC-Dor-030814	Dipodomys ordii	38.05	1.00e-16	80.90
IUUC-Dse-031354	Dothistroma septosporum	23.21	2.00e-18	87.00
IUUC-Ete-032814	Echinops telfairi	43.60	2.00e-55	209.00
IUUC-Eca-033332	Equus caballus	41.50	5.00e-81	294.00
IUUC-Fca-035571	Felis catus	42.50	2.00e-81	296.00
IUUC-Fal-037421	Ficedula albicollis	44.83	5.00e-80	291.00
IUUC-Fox-038069	Fusarium oxysporum	22.84	5.00e-17	82.00
IUUC-Fso-038192	Fusarium solani	23.74	3.00e-18	86.30
IUUC-Gmo-039365	Gadus morhua	41.57	2.00e-75	276.00
IUUC-Gga-041153	Gallus gallus	44.00	4.00e-81	295.00
IUUC-Gac-041984	Gasterosteus aculeatus	37.59	3.00e-73	268.00
IUUC-Gma-043734	Glycine max	35.49	3.00e-48	185.00
IUUC-Ggo-044419	Gorilla gorilla	41.93	2.00e-80	293.00
IUUC-Hsa-045862	Homo sapiens	42.33	7.00e-82	297.00
IUUC-Hvu-047728	Hordeum vulgare	30.64	1.00e-44	173.00
IUUC-Itr-048786	Ictidomys tridecemlineatus	42.15	6.00e-82	298.00
IUUC-Lch-050616	Latimeria chalumnae	41.11	1.00e-73	270.00
IUUC-Lpe-051222	Leersia perrieri	31.18	4.00e-47	181.00
IUUC-Loc-052564	Lepisosteus oculatus	39.70	1.00e-71	263.00
IUUC-Lma-053098	Leptosphaeria maculans	23.46	2.00e-16	80.10
IUUC-Laf-053892	Loxodonta africana	42.82	2.00e-79	289.00
IUUC-Mcc-055854	Macaca mulatta	41.87	2.00e-82	299.00
IUUC-Mor-057144	Magnaporthe oryzae	25.43	3.00e-11	63.20
IUUC-Mtr-058510	Medicago truncatula	31.78	2.00e-42	166.00
IUUC-Mla-058823	Melampsora laricipopulina	25.92	6.00e-19	88.20
IUUC-Mga-060128	Meleagris gallopavo	44.29	1.00e-81	296.00
IUUC-Mvi-060475	Microbotryum violaceum	30.86	1.00e-44	173.00
IUUC-Mmr-061331	Microcebus murinus	42.36	5.00e-80	291.00
IUUC-Mdo-063020	Monodelphis domestica	41.48	1.00e-79	290.00
IUUC-Mmu-063713	Mus musculus	42.33	2.00e-81	296.00
IUUC-Mac-064653	Musa acuminata	32.45	3.00e-42	165.00
IUUC-Mpu-066490	Mustela putorius furo	42.06	3.00e-81	295.00
IUUC-Mlu-067900	Myotis lucifugus	42.61	2.00e-81	296.00
IUUC-Nfi-068433	Neosartorya fischeri	23.67	1.00e-22	101.00
IUUC-Ncr-068776	Neurospora crassa	27.05	1.00e-18	87.40
IUUC-Nle-069675	Nomascus leucogenys	39.83	3.00e-76	279.00
IUUC-Opr-070769	Ochotona princeps	32.68	4.00e-21	95.90
IUUC-Ont-071441	Oreochromis niloticus	40.79	7.00e-73	267.00
IUUC-Oan-072757	Ornithorhynchus anatinus	40.31	2.00e-78	286.00
IUUC-Ocu-074670	Oryctolagus cuniculus	42.90	3.00e-81	295.00
IUUC-Oba-075844	Oryza barthii	31.34	3.00e-46	179.00
IUUC-Obr-076625	Oryza brachyantha	32.02	4.00e-48	185.00
IUUC-Ogl-077771	Oryza glaberrima	31.34	3.00e-46	178.00
IUUC-Ogu-078475	Oryza glumaepatula	28.49	4.00e-37	148.00
IUUC-Oin-079958	Oryza indica	31.34	2.00e-46	179.00
IUUC-Olo-080311	Oryza longistaminata	32.76	6.00e-41	160.00
IUUC-Ome-081985	Oryza meridionalis	31.62	3.00e-46	178.00
IUUC-Oni-082921	Oryza nivara	31.34	2.00e-46	179.00
IUUC-Opu-083174	Oryza punctata	30.79	1.00e-46	180.00
IUUC-Oru-084338	Oryza rufipogon	31.34	3.00e-46	179.00
IUUC-Olu-087907	Ostreococcus lucimarinus	27.66	9.00e-23	100.00
IUUC-Oga-088358	Otolemur garnettii	42.94	1.00e-81	296.00
IUUC-Oar-089994	Ovis aries	41.23	2.00e-81	296.00
IUUC-Ptr-091338	Pan troglodytes	42.33	4.00e-82	298.00
IUUC-Pan-091759	Papio anubis	41.76	6.00e-81	294.00
IUUC-Psi-093211	Pelodiscus sinensis	43.59	2.00e-78	286.00
IUUC-Pma-094588	Petromyzon marinus	40.23	7.00e-46	176.00
IUUC-Pno-094964	Phaeosphaeria nodorum	26.42	2.00e-20	92.80
IUUC-Ppa-095159	Physcomitrella patens	34.07	2.00e-52	198.00
IUUC-Pfo-096592	Poecilia formosa	38.59	7.00e-63	234.00
IUUC-Pab-098597	Pongo abelii	28.98	6.00e-35	141.00
IUUC-Pop-099255	Populus trichocarpa	34.01	1.00e-49	189.00
IUUC-Pca-100593	Procavia capensis	36.92	5.00e-60	224.00
IUUC-Ppe-101333	Prunus persica	31.85	6.00e-45	174.00
IUUC-Pva-102283	Pteropus vampyrus	45.18	3.00e-75	275.00
IUUC-Pgr-103383	Puccinia graminis	25.69	8.00e-15	74.30
IUUC-Ptt-103974	Puccinia triticina	26.27	8.00e-14	70.90
IUUC-Pte-104329	Pyrenophora teres	28.52	1.00e-17	84.00
IUUC-Pyt-104424	Pyrenophora triticirepentis	28.14	4.00e-17	82.40
IUUC-Rno-105720	Rattus norvegicus	41.78	2.00e-81	296.00
IUUC-Sha-106891	Sarcophilus harrisii	40.90	7.00e-71	261.00
IUUC-Sja-107723	Schizosaccharomyces japonicus	28.21	5.00e-26	111.00
IUUC-Spo-108060	Schizosaccharomyces pombe	26.11	5.00e-22	98.20
IUUC-Ssl-108481	Sclerotinia sclerotiorum	26.15	1.00e-13	70.90
IUUC-Sit-109862	Setaria italica	32.29	2.00e-47	182.00
IUUC-Sly-111468	Solanum lycopersicum	30.59	1.00e-41	163.00
IUUC-Stu-112346	Solanum tuberosum	31.40	3.00e-42	165.00
IUUC-Sar-113734	Sorex araneus	40.28	3.00e-27	116.00
IUUC-Sbi-114076	Sorghum bicolor	32.08	5.00e-47	181.00
IUUC-Sre-114918	Sporisorium reilianum	24.22	5.00e-15	75.90
IUUC-Ssc-115561	Sus scrofa	41.67	7.00e-81	294.00
IUUC-Tgu-117011	Taeniopygia guttata	43.97	1.00e-79	290.00
IUUC-Tru-118411	Takifugu rubripes	39.38	2.00e-66	246.00
IUUC-Tsy-119367	Tarsius syrichta	40.20	2.00e-59	223.00
IUUC-Tni-120301	Tetraodon nigroviridis	39.38	1.00e-67	250.00
IUUC-Tca-121265	Theobroma cacao	32.02	5.00e-46	177.00
IUUC-Tre-121997	Trichoderma reesei	24.39	1.00e-16	81.30
IUUC-Tvi-122292	Trichoderma virens	23.84	5.00e-18	85.50
IUUC-Tae-123660	Triticum aestivum	30.97	3.00e-45	175.00
IUUC-Tur-126794	Triticum urartu	31.14	5.00e-37	147.00
IUUC-Tme-127090	Tuber melanosporum	27.51	4.00e-21	94.70
IUUC-Tbe-127646	Tupaia belangeri	37.33	4.00e-68	252.00
IUUC-Ttr-128171	Tursiops truncatus	41.78	8.00e-82	297.00
IUUC-Uma-129525	Ustilago maydis	23.03	2.00e-13	70.10
IUUC-Vda-129871	Verticillium dahliae	27.20	6.00e-17	82.00
IUUC-Vpa-130554	Vicugna pacos	36.65	2.00e-26	113.00
IUUC-Vvi-131698	Vitis vinifera	34.28	6.00e-48	184.00
IUUC-Xtr-131962	Xenopus tropicalis	41.55	3.00e-81	295.00
IUUC-Xma-133803	Xiphophorus maculatus	40.23	3.00e-71	262.00
IUUC-Zma-135932	Zea mays	29.89	1.00e-43	170.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence