iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000102606.17	ENST00000317133.9	ENSP00000325994.5
ENSG00000102606.17	ENST00000469877.5	ENSP00000418235.1
ENSG00000102606.17	ENST00000218789.9	ENSP00000218789.5
ENSG00000102606.17	ENST00000375736.8	ENSP00000364888.4
ENSG00000102606.17	ENST00000426768.2	ENSP00000389890.2
ENSG00000102606.17	ENST00000478679.5	ENSP00000417596.1
ENSG00000102606.17	ENST00000544132.2	ENSP00000445384.2
ENSG00000102606.17	ENST00000375739.6	ENSP00000364891.2
ENSG00000102606.17	ENST00000375741.6	ENSP00000364893.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.40e-15	56.5	188	242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 188  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNGRTGWFPSNYVREVK 242
           78999*********************7..999*******..8**************996 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTGCCGTC TGGGCTCTCC AGGTTCGGCC TGCTGCTTTC ACAGCCCAGA TCTTCGGCGT 60
CCCCGAGACG CAGCCAGGCG CCCGGCCCGG CCCGGCCCGG CCCTCTGCAC AGCCCCACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001726--C:ruffle
GO:0000322--C:storage vacuole
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0019901--F:protein kinase binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048013--P:ephrin receptor signaling pathway
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007399--P:nervous system development
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:0043547--P:positive regulation of GTPase activity
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction

KEGG

hsa:8874

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	91.99	0.00e+00	1335.00
IUUC-Aca-004591	Anolis carolinensis	89.52	0.00e+00	1252.00
IUUC-Ago-008003	Ashbya gossypii	25.00	5.00e-15	76.60
IUUC-Ame-010759	Astyanax mexicanus	74.59	0.00e+00	1134.00
IUUC-Bta-013328	Bos taurus	90.53	0.00e+00	1321.00
IUUC-Bci-013864	Botrytis cinerea	41.54	1.00e-11	66.20
IUUC-Cja-018742	Callithrix jacchus	96.71	0.00e+00	1273.00
IUUC-Cfa-020756	Canis familiaris	93.99	0.00e+00	1135.00
IUUC-Cpo-021284	Cavia porcellus	90.38	0.00e+00	1242.00
IUUC-Csa-023162	Chlorocebus sabaeus	97.22	0.00e+00	1412.00
IUUC-Cho-024736	Choloepus hoffmanni	73.62	2.00e-173	602.00
IUUC-Cin-025535	Ciona intestinalis	39.92	3.00e-94	339.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	41.43	2.00e-11	65.50
IUUC-Cne-026866	Cryptococcus neoformans	50.79	2.00e-13	72.40
IUUC-Dre-028646	Danio rerio	74.72	0.00e+00	1126.00
IUUC-Dno-029461	Dasypus novemcinctus	93.31	0.00e+00	1351.00
IUUC-Dor-030623	Dipodomys ordii	82.35	0.00e+00	1081.00
IUUC-Dme-032219	Drosophila melanogaster	46.51	5.00e-103	369.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	805.00
IUUC-Eca-034137	Equus caballus	96.22	0.00e+00	1191.00
IUUC-Fca-035742	Felis catus	95.08	0.00e+00	1115.00
IUUC-Fal-037205	Ficedula albicollis	93.81	0.00e+00	1025.00
IUUC-Fox-037757	Fusarium oxysporum	38.89	2.00e-11	65.50
IUUC-Gmo-039475	Gadus morhua	74.49	0.00e+00	995.00
IUUC-Gga-040539	Gallus gallus	93.15	0.00e+00	974.00
IUUC-Gac-042615	Gasterosteus aculeatus	71.64	0.00e+00	932.00
IUUC-Ggo-044470	Gorilla gorilla	98.43	0.00e+00	1251.00
IUUC-Loc-052146	Lepisosteus oculatus	83.10	0.00e+00	1218.00
IUUC-Laf-053891	Loxodonta africana	89.02	0.00e+00	1290.00
IUUC-Mcc-055483	Macaca mulatta	99.38	0.00e+00	1476.00
IUUC-Mga-059410	Meleagris gallopavo	93.20	0.00e+00	1162.00
IUUC-Mmr-060758	Microcebus murinus	94.52	0.00e+00	1341.00
IUUC-Mdo-061900	Monodelphis domestica	90.86	0.00e+00	1276.00
IUUC-Mmu-063849	Mus musculus	92.03	0.00e+00	1312.00
IUUC-Mpu-065876	Mustela putorius furo	94.11	0.00e+00	1126.00
IUUC-Mlu-067970	Myotis lucifugus	95.63	0.00e+00	1186.00
IUUC-Nle-069685	Nomascus leucogenys	96.04	0.00e+00	1071.00
IUUC-Opr-071132	Ochotona princeps	64.61	0.00e+00	731.00
IUUC-Ont-071815	Oreochromis niloticus	75.44	0.00e+00	1124.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.35	0.00e+00	1035.00
IUUC-Ola-086663	Oryzias latipes	73.14	0.00e+00	957.00
IUUC-Oga-088103	Otolemur garnettii	94.79	0.00e+00	1143.00
IUUC-Ptr-091162	Pan troglodytes	96.81	0.00e+00	1328.00
IUUC-Pan-092093	Papio anubis	86.27	0.00e+00	1256.00
IUUC-Pma-094701	Petromyzon marinus	61.40	2.00e-131	462.00
IUUC-Pfo-096736	Poecilia formosa	71.19	0.00e+00	1025.00
IUUC-Pab-097641	Pongo abelii	96.73	0.00e+00	1347.00
IUUC-Pva-102819	Pteropus vampyrus	90.41	0.00e+00	1301.00
IUUC-Pgr-103400	Puccinia graminis	27.00	5.00e-20	94.00
IUUC-Pte-104123	Pyrenophora teres	42.86	2.00e-10	61.60
IUUC-Pyt-104567	Pyrenophora triticirepentis	42.86	2.00e-10	61.60
IUUC-Rno-106099	Rattus norvegicus	91.79	0.00e+00	1284.00
IUUC-Sha-106845	Sarcophilus harrisii	92.41	0.00e+00	1119.00
IUUC-Stu-112434	Solanum tuberosum	46.15	1.00e-09	57.40
IUUC-Ssc-116036	Sus scrofa	94.27	0.00e+00	1115.00
IUUC-Tgu-117498	Taeniopygia guttata	87.75	0.00e+00	1249.00
IUUC-Tru-118278	Takifugu rubripes	72.33	0.00e+00	962.00
IUUC-Tsy-118990	Tarsius syrichta	93.54	0.00e+00	988.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.57	0.00e+00	1009.00
IUUC-Ttr-128922	Tursiops truncatus	88.35	0.00e+00	1159.00
IUUC-Xtr-132012	Xenopus tropicalis	82.85	0.00e+00	1096.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence