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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Ath-007281
UUCD1 version UUC-ArT-01412
Ensembl Protein ID AT1G75950.1
UniProt Accession Q39255; P92992; SKP1A_ARATH
Genbank Protein ID AAB17535.1; AAC63109.1; AAC14444.1; AAF26761.1; AEE35780.1; AAL87354.1; AAM45019.1; AAB38862.1
Protein Name SKP1-like protein 1A; UFO-binding protein 1
Genbank Nucleotide ID U60981; U97020; AF059294; AC007396; CP002684; AY080884; AY113971; U70034
Gene Name SKP1A; ASK1; SKP1; UIP1; At1g75950; T4O12.17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G75950 AT1G75950.1 AT1G75950.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexPINAHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPPTdbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/SKP1 SKP1 12169662; 12795696; 16983093
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/SKP1 2.00e-31 108.8 111 158
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/SKP1

   S: 1    ksLLdltcktVadmikgktpeeiRktFnienDftpeEeakvReEnqWA 48
    k+LLdltc+tVadmikgktpeeiR+tFni+nDftpeEe++vR+EnqWA
   Q: 111 KNLLDLTCQTVADMIKGKTPEEIRTTFNIKNDFTPEEEEEVRRENQWA 158
    79*********************************************9 PP
   

Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description



     Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.
Protein Sequence
(Fasta)
MSAKKIVLKS SDGESFEVEE AVALESQTIA HMVEDDCVDN GVPLPNVTSK ILAKVIEYCK 60
RHVEAAASKA EAVEGAATSD DDLKAWDADF MKIDQATLFE LILAANYLNI KNLLDLTCQT 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ath-007281|E3,SKP1|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
AAAATTTGAA ACAATTTCCT AATTTCCCTA AACTTGCGAC TTTTTAACAA TCGACCGACT 60
TATCAAAATT AGGGATTGTT TTATATATAA AGAGAGACGC ATCTCTTTAT TTCATTCATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ath-007281|E3,SKP1|Arabidopsis thaliana
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0927--Auxin signaling pathway
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0936--Ethylene signaling pathway
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016897--SKP1
IPR001232--SKP1-like
IPR011333--SKP1/BTB/POZ
IPR016072--Skp1_comp_dimer
IPR016073--Skp1_comp_POZ

Pfam

PF01466--Skp1
PF03931--Skp1_POZ

SMART

SM00512--Skp1

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0009524--C:phragmoplast
GO:0005886--C:plasma membrane
GO:0005819--C:spindle
GO:0009734--P:auxin-activated signaling pathway
GO:0007059--P:chromosome segregation
GO:0009873--P:ethylene-activated signaling pathway
GO:0000226--P:microtubule cytoskeleton organization
GO:0007275--P:multicellular organism development
GO:0045910--P:negative regulation of DNA recombination
GO:0016567--P:protein ubiquitination
GO:0046686--P:response to cadmium ion
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG ath:AT1G75950
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002858 Amborella trichopoda 77.07 8.00e-57 211.00
IUUC-Bgr-012280 Blumeria graminis 51.39 3.00e-34 136.00
IUUC-Bci-013888 Botrytis cinerea 53.15 5.00e-29 119.00
IUUC-Bol-015842 Brassica oleracea 93.12 2.00e-80 290.00
IUUC-Bra-016913 Brassica rapa 93.12 2.00e-80 290.00
IUUC-Cho-024854 Choloepus hoffmanni 42.25 4.00e-12 62.80
IUUC-Cgl-026548 Colletotrichum gloeosporioides 47.62 4.00e-35 139.00
IUUC-Dme-032028 Drosophila melanogaster 55.35 5.00e-38 149.00
IUUC-Ete-033117 Echinops telfairi 55.62 2.00e-36 144.00
IUUC-Fox-037761 Fusarium oxysporum 47.65 2.00e-35 140.00
IUUC-Fso-038451 Fusarium solani 46.62 2.00e-34 137.00
IUUC-Itr-047900 Ictidomys tridecemlineatus 55.00 2.00e-37 147.00
IUUC-Lma-053020 Leptosphaeria maculans 46.58 3.00e-33 133.00
IUUC-Mor-057176 Magnaporthe oryzae 46.58 6.00e-36 142.00
IUUC-Mpo-057471 Magnaporthe poae 47.30 6.00e-36 142.00
IUUC-Mac-064537 Musa acuminata 80.38 1.00e-59 221.00
IUUC-Ncr-068658 Neurospora crassa 45.89 2.00e-35 140.00
IUUC-Obr-076218 Oryza brachyantha 78.75 3.00e-59 220.00
IUUC-Pno-094810 Phaeosphaeria nodorum 44.76 1.00e-30 125.00
IUUC-Ppa-095274 Physcomitrella patens 73.12 1.00e-59 221.00
IUUC-Pca-100783 Procavia capensis 51.52 9.00e-30 122.00
IUUC-Ppe-101549 Prunus persica 83.22 1.00e-63 234.00
IUUC-Pte-104224 Pyrenophora teres 45.21 4.00e-30 123.00
IUUC-Pyt-104750 Pyrenophora triticirepentis 45.21 3.00e-30 123.00
IUUC-Ssl-108591 Sclerotinia sclerotiorum 48.95 4.00e-34 136.00
IUUC-Sly-111529 Solanum lycopersicum 78.62 7.00e-65 238.00
IUUC-Stu-111940 Solanum tuberosum 79.35 6.00e-64 235.00
IUUC-Tca-121022 Theobroma cacao 81.13 1.00e-67 247.00
IUUC-Tae-123210 Triticum aestivum 77.71 4.00e-63 233.00
Created Date 25-Jun-2017

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