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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046471
Ensembl Protein ID ENSP00000274498.4
UniProt Accession Q9UNA1; O75117; Q5D035; Q9BYS6; Q9BYS7; Q9UJ00; RHG26_HUMAN
Genbank Protein ID AAD39482.1; CAA71414.2; EAW61876.1; AAH68555.1; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29145.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29146.2; CAC29
Protein Name Rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26
Genbank Nucleotide ID AF141884; Y10388; CH471062; BC068555; AJ309466; AJ309467; AJ309468; AJ309469; AJ309470; AJ309471; AJ309472; AJ309473; AJ309474; AJ309475; AJ309476; AJ309477; AJ309478; AJ309479; AJ309480; AJ309481; AJ309482; AJ309483; AJ309484; AJ309485; AJ309486; AJ309487; AJ309466; AJ309467; AJ309468; AJ309469; AJ309470; AJ309471; AJ309472; AJ309473; AJ309474; AJ309475; AJ309476; AJ309477; AJ309478; AJ309479; AJ309480; AJ309481; AJ309482; AJ309483; AJ309484; AJ309485; AJ309487; AB014521
Gene Name ARHGAP26; GRAF; KIAA0621; OPHN1L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145819.15 ENST00000274498.8 ENSP00000274498.4
ENSG00000145819.15 ENST00000378004.7 ENSP00000367243.3
ENSG00000145819.15 ENST00000378013.2 ENSP00000367252.2
ENSG00000145819.15 ENST00000443674.5 ENSP00000393276.1
ENSG00000145819.15 ENST00000418236.5 ENSP00000416889.1
ENSG00000145819.15 ENST00000443045.1 ENSP00000392186.1
ENSG00000145819.15 ENST00000419676.5 ENSP00000413283.1
ENSG00000145819.15 ENST00000424007.1 ENSP00000400565.1
ENSG00000145819.15 ENST00000421521.5 ENSP00000389137.1
ENSG00000145819.15 ENST00000425417.1 ENSP00000403388.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.40e-12 47.4 760 812
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           k ++ly  +a++d eL++++G v + + + +q+ gWl+g  +l+gk Gl+Pen+ve
   Q: 760  KAKALYACKAEHDSELSFTAGTVFDNV-HPSQEPGWLEG--TLNGKTGLIPENYVE 812
           679************************.***********..8*************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.
 Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.
Protein Sequence
(Fasta)
MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL KNLSSAKRKF 60
ADSLNEFKFQ CIGDAETDDE MCIARSLQEF ATVLRNLEDE RIRMIENASE VLITPLEKFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046471|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGGGCGG CCGAGGCTGC TGTGAGAGGG CGCTCGAGGC TGCCGAGAGC TAGCTAGCGA 60
AGGAGGCGGG GAGGCGGCGT CTGCACTCGC TCGCCCGCTC GCTCGCTTCC CGGCGCCGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046471|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0343--GTPase activation
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR030061--RHG26
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain
PROSITE

PS50003--PH_DOMAIN
PS50238--RHOGAP
PS50002--SH3
Pfam

PF00169--PH
PF00620--RhoGAP
PF14604--SH3_9
SMART

SM00233--PH
SM00324--RhoGAP
SM00326--SH3
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005096--F:GTPase activator activity
GO:0005543--F:phospholipid binding
GO:0030036--P:actin cytoskeleton organization
GO:0007399--P:nervous system development
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction
KEGG hsa:23092
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001613 Ailuropoda melanoleuca 97.67 0.00e+00 1384.00
IUUC-Apl-003321 Anas platyrhynchos 85.97 0.00e+00 1148.00
IUUC-Aca-004570 Anolis carolinensis 90.02 0.00e+00 1172.00
IUUC-Ame-011422 Astyanax mexicanus 79.02 0.00e+00 856.00
IUUC-Bta-013262 Bos taurus 98.61 0.00e+00 1108.00
IUUC-Cel-018542 Caenorhabditis elegans 43.14 9.00e-131 461.00
IUUC-Cja-019208 Callithrix jacchus 99.70 0.00e+00 1211.00
IUUC-Cfa-020928 Canis familiaris 98.56 0.00e+00 1212.00
IUUC-Cpo-021338 Cavia porcellus 98.03 0.00e+00 1432.00
IUUC-Csa-023570 Chlorocebus sabaeus 99.54 0.00e+00 1211.00
IUUC-Dno-029143 Dasypus novemcinctus 97.79 0.00e+00 1423.00
IUUC-Dor-030697 Dipodomys ordii 98.16 0.00e+00 1415.00
IUUC-Dme-032147 Drosophila melanogaster 45.64 2.00e-138 487.00
IUUC-Ete-032645 Echinops telfairi 88.50 0.00e+00 1044.00
IUUC-Eca-033791 Equus caballus 98.16 0.00e+00 1426.00
IUUC-Eeu-035202 Erinaceus europaeus 83.93 1.00e-179 623.00
IUUC-Fca-036131 Felis catus 98.25 0.00e+00 1400.00
IUUC-Fal-037129 Ficedula albicollis 93.28 0.00e+00 1132.00
IUUC-Gga-041023 Gallus gallus 91.36 0.00e+00 1176.00
IUUC-Ggo-044863 Gorilla gorilla 99.39 0.00e+00 1425.00
IUUC-Itr-049060 Ictidomys tridecemlineatus 98.16 0.00e+00 1449.00
IUUC-Lch-050300 Latimeria chalumnae 76.64 0.00e+00 1045.00
IUUC-Loc-052782 Lepisosteus oculatus 81.18 0.00e+00 1054.00
IUUC-Laf-053585 Loxodonta africana 96.81 0.00e+00 1389.00
IUUC-Mcc-055458 Macaca mulatta 99.54 0.00e+00 1215.00
IUUC-Meu-056107 Macropus eugenii 77.89 0.00e+00 1093.00
IUUC-Mga-059914 Meleagris gallopavo 88.76 0.00e+00 1045.00
IUUC-Mmr-060728 Microcebus murinus 98.29 0.00e+00 1309.00
IUUC-Mdo-062387 Monodelphis domestica 89.46 0.00e+00 1342.00
IUUC-Mmu-063756 Mus musculus 97.89 0.00e+00 1215.00
IUUC-Nle-069043 Nomascus leucogenys 94.81 0.00e+00 895.00
IUUC-Opr-071168 Ochotona princeps 85.14 0.00e+00 1201.00
IUUC-Ont-072338 Oreochromis niloticus 77.84 0.00e+00 900.00
IUUC-Oan-073441 Ornithorhynchus anatinus 92.64 0.00e+00 976.00
IUUC-Ocu-073915 Oryctolagus cuniculus 96.31 0.00e+00 1395.00
IUUC-Ola-086319 Oryzias latipes 76.76 0.00e+00 938.00
IUUC-Oar-089349 Ovis aries 98.56 0.00e+00 1207.00
IUUC-Ptr-091027 Pan troglodytes 99.39 0.00e+00 1430.00
IUUC-Pan-092791 Papio anubis 99.70 0.00e+00 1212.00
IUUC-Psi-093144 Pelodiscus sinensis 91.52 0.00e+00 1215.00
IUUC-Pab-097783 Pongo abelii 99.51 0.00e+00 1432.00
IUUC-Pva-102980 Pteropus vampyrus 97.30 0.00e+00 1468.00
IUUC-Rno-105142 Rattus norvegicus 97.71 0.00e+00 1242.00
IUUC-Sha-107213 Sarcophilus harrisii 92.47 0.00e+00 1120.00
IUUC-Tru-117767 Takifugu rubripes 74.96 0.00e+00 977.00
IUUC-Tsy-119150 Tarsius syrichta 95.82 0.00e+00 1388.00
IUUC-Tni-119893 Tetraodon nigroviridis 77.06 0.00e+00 693.00
IUUC-Ttr-129028 Tursiops truncatus 87.43 0.00e+00 1119.00
Created Date 25-Jun-2017

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