iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132134

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3

Genbank Nucleotide ID

BC135572

Gene Name

dcun1d3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000016729.2	ENSXETT00000036490.2	ENSXETP00000036490.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/DCUN1	2.40e-80	269.2	86	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkd 90
           s++++eelf rYkd++ed+i++eg+e+fc+dl vdp++++vLvlawk++aat+c+f+r+ef++g++a+++d ie++++++++l +e+k+
   Q: 86   SVQRIEELFWRYKDEREDAILEEGMERFCNDLYVDPTEFRVLVLAWKFQAATMCKFTRREFFEGCKAINADGIEGICARFPSLLNEAKQ 174
           679************************************************************************************** PP
   S: 91   eqkfkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeeg 175
           e+kfkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++ +ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++
   Q: 175  EDKFKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNKPLILDQWLDFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDE 263
           ***************998899**********************************9889****************************** PP
   S: 176  aWPvliDefveylk 189
           aWP+l+D+fve+++
   Q: 264  AWPSLFDTFVEWEM 277
           ************85 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.

Protein Sequence
(Fasta)

MGQCVTKCKN PSSTLGSKNG ERESSKPHKR SSSHKDEHLS ICGKASREIL VNGTKKGDVS 60
LEASQPLAAG GDTKKKEQGT GAELSSVQRI EELFWRYKDE REDAILEEGM ERFCNDLYVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTGACGTC GGTAGAAGTG CGCCGGGCGC AGCGGGCACG TCACGGCTGG AGGAAAGGAA 60
GGAGGGGGAG CTGGAAGGTG CGGACGTCGC AGGCTCACAA GTGATTGGGG CGCTGCCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
GO:0009314--P:response to radiation

KEGG

xtr:100124860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001689	Ailuropoda melanoleuca	80.14	8.00e-129	452.00
IUUC-Apl-003497	Anas platyrhynchos	84.26	8.00e-140	489.00
IUUC-Aca-004961	Anolis carolinensis	81.42	1.00e-138	484.00
IUUC-Aor-009902	Aspergillus oryzae	34.40	3.00e-11	60.10
IUUC-Ame-011413	Astyanax mexicanus	65.09	9.00e-103	366.00
IUUC-Bta-013338	Bos taurus	81.59	4.00e-131	460.00
IUUC-Cja-019458	Callithrix jacchus	80.14	3.00e-129	454.00
IUUC-Cfa-020160	Canis familiaris	80.51	2.00e-129	454.00
IUUC-Cpo-021835	Cavia porcellus	75.74	6.00e-124	436.00
IUUC-Csa-023328	Chlorocebus sabaeus	80.14	2.00e-129	454.00
IUUC-Cho-024888	Choloepus hoffmanni	80.29	1.00e-129	455.00
IUUC-Cin-025134	Ciona intestinalis	54.00	9.00e-62	230.00
IUUC-Csv-025904	Ciona savignyi	51.22	8.00e-33	131.00
IUUC-Dre-027780	Danio rerio	62.32	5.00e-96	343.00
IUUC-Dno-028866	Dasypus novemcinctus	79.78	4.00e-127	447.00
IUUC-Dor-030387	Dipodomys ordii	80.36	2.00e-128	451.00
IUUC-Dme-032081	Drosophila melanogaster	48.98	7.00e-47	180.00
IUUC-Eca-033857	Equus caballus	80.51	1.00e-129	455.00
IUUC-Eeu-034825	Erinaceus europaeus	70.82	9.00e-115	405.00
IUUC-Fca-036130	Felis catus	80.14	2.00e-128	451.00
IUUC-Fal-037296	Ficedula albicollis	82.30	1.00e-134	472.00
IUUC-Gmo-039626	Gadus morhua	65.25	2.00e-99	355.00
IUUC-Ggr-039959	Gaeumannomyces graminis	26.89	7.00e-15	75.50
IUUC-Gga-040741	Gallus gallus	82.24	4.00e-137	480.00
IUUC-Gac-042271	Gasterosteus aculeatus	65.59	6.00e-94	337.00
IUUC-Ggo-044727	Gorilla gorilla	80.14	2.00e-129	454.00
IUUC-Hsa-046288	Homo sapiens	80.51	9.00e-130	456.00
IUUC-Itr-049054	Ictidomys tridecemlineatus	77.38	7.00e-135	473.00
IUUC-Lch-050289	Latimeria chalumnae	77.23	3.00e-130	457.00
IUUC-Loc-052455	Lepisosteus oculatus	69.06	2.00e-106	378.00
IUUC-Laf-054369	Loxodonta africana	79.06	7.00e-124	436.00
IUUC-Mcc-055413	Macaca mulatta	65.34	4.00e-94	337.00
IUUC-Meu-056535	Macropus eugenii	77.38	8.00e-133	466.00
IUUC-Mga-059290	Meleagris gallopavo	83.28	5.00e-138	483.00
IUUC-Mmr-060689	Microcebus murinus	80.51	1.00e-129	455.00
IUUC-Mdo-062128	Monodelphis domestica	76.39	5.00e-126	443.00
IUUC-Mmu-064396	Mus musculus	77.70	9.00e-136	475.00
IUUC-Mpu-065926	Mustela putorius furo	80.14	8.00e-129	452.00
IUUC-Mlu-067044	Myotis lucifugus	78.31	5.00e-133	466.00
IUUC-Nle-069346	Nomascus leucogenys	80.14	2.00e-129	454.00
IUUC-Opr-070682	Ochotona princeps	78.70	5.00e-123	433.00
IUUC-Ont-071772	Oreochromis niloticus	70.71	1.00e-104	372.00
IUUC-Oan-072765	Ornithorhynchus anatinus	77.70	2.00e-127	447.00
IUUC-Ocu-074272	Oryctolagus cuniculus	90.67	4.00e-104	370.00
IUUC-Ola-087561	Oryzias latipes	67.77	7.00e-106	376.00
IUUC-Oga-088440	Otolemur garnettii	65.45	1.00e-98	352.00
IUUC-Oar-089403	Ovis aries	81.59	3.00e-131	460.00
IUUC-Ptr-091384	Pan troglodytes	80.14	2.00e-129	454.00
IUUC-Pan-092650	Papio anubis	80.14	2.00e-129	454.00
IUUC-Psi-093806	Pelodiscus sinensis	81.64	1.00e-132	465.00
IUUC-Pma-094196	Petromyzon marinus	52.04	4.00e-84	304.00
IUUC-Pfo-096584	Poecilia formosa	68.68	4.00e-103	367.00
IUUC-Pab-098605	Pongo abelii	80.14	2.00e-129	454.00
IUUC-Pca-100933	Procavia capensis	62.18	2.00e-86	311.00
IUUC-Pva-102172	Pteropus vampyrus	80.00	3.00e-130	457.00
IUUC-Rno-105406	Rattus norvegicus	78.03	3.00e-136	477.00
IUUC-Sha-106531	Sarcophilus harrisii	77.05	4.00e-133	467.00
IUUC-Sar-113051	Sorex araneus	64.60	2.00e-95	341.00
IUUC-Ssc-115555	Sus scrofa	80.51	1.00e-129	455.00
IUUC-Tgu-117178	Taeniopygia guttata	83.61	8.00e-138	482.00
IUUC-Tru-117876	Takifugu rubripes	68.75	3.00e-105	374.00
IUUC-Tsy-118790	Tarsius syrichta	78.57	1.00e-109	389.00
IUUC-Tni-119673	Tetraodon nigroviridis	66.89	7.00e-105	373.00
IUUC-Tbe-127429	Tupaia belangeri	80.14	8.00e-130	456.00
IUUC-Ttr-128467	Tursiops truncatus	80.51	1.00e-129	455.00
IUUC-Vpa-130376	Vicugna pacos	55.07	1.00e-73	269.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence