iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000040423.10	ENSMUST00000161609.7	ENSMUSP00000124871.1
ENSMUSG00000040423.10	ENSMUST00000035911.4	ENSMUSP00000037178.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	miRecords
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.85	0.00e+00	1946.00	IUUC-Hsa-046163

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (PubMed:23663784). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (PubMed:26000482). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation.

Protein Sequence
(Fasta)

MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC PFDQTTINTD 60
IELLPVNSAL LQLVGAQIPE QQPITLCSGV EDTKHYEEAK KCVEELALYL KPLSSARGVG 120

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Nucleotide Sequence
(Fasta)

GAGGAAGAGG AAGGGGACGA GGACAACGAG CGACGGGCGG CGGAGGACGC GGAGGAGGAA 60
GGGGAGGCCG ACCAACAAGA TGGCCCCTGC TGCAGGAGCA GCCTCAGCAG CAGCAGGTGG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032671--RC3H1
IPR027370--Znf-RING_LisH
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00642--zf-CCCH
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00356--ZnF_C3H1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0010494--C:cytoplasmic stress granule
GO:0000932--C:P-body
GO:0003730--F:mRNA 3'-UTR binding
GO:0003729--F:mRNA binding
GO:0003723--F:RNA binding
GO:0035613--F:RNA stem-loop binding
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001782--P:B cell homeostasis
GO:0071347--P:cellular response to interleukin-1
GO:0033962--P:cytoplasmic mRNA processing body assembly
GO:0048535--P:lymph node development
GO:0046007--P:negative regulation of activated T cell proliferation
GO:0030889--P:negative regulation of B cell proliferation
GO:0002635--P:negative regulation of germinal center formation
GO:0045623--P:negative regulation of T-helper cell differentiation
GO:0000956--P:nuclear-transcribed mRNA catabolic process
GO:0000288--P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0010468--P:regulation of gene expression
GO:0002634--P:regulation of germinal center formation
GO:0043488--P:regulation of mRNA stability
GO:0050856--P:regulation of T cell receptor signaling pathway
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0042098--P:T cell proliferation
GO:0061470--P:T follicular helper cell differentiation

KEGG

mmu:381305

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001700	Ailuropoda melanoleuca	93.55	0.00e+00	1914.00
IUUC-Apl-003290	Anas platyrhynchos	84.35	0.00e+00	1786.00
IUUC-Aca-004905	Anolis carolinensis	82.87	0.00e+00	1736.00
IUUC-Ame-011475	Astyanax mexicanus	63.92	0.00e+00	1207.00
IUUC-Cja-019907	Callithrix jacchus	93.03	0.00e+00	1949.00
IUUC-Cfa-020679	Canis familiaris	93.20	0.00e+00	1878.00
IUUC-Cpo-022110	Cavia porcellus	90.04	0.00e+00	1916.00
IUUC-Csa-024166	Chlorocebus sabaeus	93.37	0.00e+00	1887.00
IUUC-Dno-029870	Dasypus novemcinctus	89.71	0.00e+00	909.00
IUUC-Dor-030934	Dipodomys ordii	83.59	0.00e+00	1432.00
IUUC-Dme-031708	Drosophila melanogaster	64.71	1.00e-162	566.00
IUUC-Ete-032652	Echinops telfairi	93.51	0.00e+00	1350.00
IUUC-Eca-033236	Equus caballus	92.23	0.00e+00	1844.00
IUUC-Eeu-035091	Erinaceus europaeus	81.82	0.00e+00	861.00
IUUC-Fca-035773	Felis catus	93.12	0.00e+00	1869.00
IUUC-Fal-036972	Ficedula albicollis	84.78	0.00e+00	1814.00
IUUC-Gmo-039303	Gadus morhua	79.93	0.00e+00	893.00
IUUC-Ggo-044691	Gorilla gorilla	87.36	0.00e+00	1796.00
IUUC-Hsa-046163	Homo sapiens	93.20	0.00e+00	1954.00
IUUC-Itr-048266	Ictidomys tridecemlineatus	89.17	0.00e+00	995.00
IUUC-Lch-050667	Latimeria chalumnae	73.76	0.00e+00	1527.00
IUUC-Loc-052404	Lepisosteus oculatus	69.09	0.00e+00	1324.00
IUUC-Laf-053618	Loxodonta africana	93.44	0.00e+00	1832.00
IUUC-Mcc-054692	Macaca mulatta	93.29	0.00e+00	1958.00
IUUC-Meu-056025	Macropus eugenii	82.15	0.00e+00	903.00
IUUC-Mmr-061188	Microcebus murinus	93.11	0.00e+00	1878.00
IUUC-Mdo-063035	Monodelphis domestica	89.33	0.00e+00	1848.00
IUUC-Mpu-066217	Mustela putorius furo	92.57	0.00e+00	1866.00
IUUC-Mlu-068023	Myotis lucifugus	91.95	0.00e+00	1885.00
IUUC-Nle-069506	Nomascus leucogenys	93.29	0.00e+00	1959.00
IUUC-Opr-070587	Ochotona princeps	79.47	0.00e+00	1527.00
IUUC-Ont-071278	Oreochromis niloticus	62.25	0.00e+00	1195.00
IUUC-Oan-073500	Ornithorhynchus anatinus	88.65	0.00e+00	1914.00
IUUC-Ocu-074299	Oryctolagus cuniculus	92.38	0.00e+00	1784.00
IUUC-Ola-086665	Oryzias latipes	61.38	0.00e+00	1220.00
IUUC-Oga-088519	Otolemur garnettii	85.98	0.00e+00	1680.00
IUUC-Oar-089246	Ovis aries	91.40	0.00e+00	1761.00
IUUC-Ptr-091102	Pan troglodytes	93.29	0.00e+00	1956.00
IUUC-Pan-091952	Papio anubis	93.04	0.00e+00	1954.00
IUUC-Pfo-097227	Poecilia formosa	61.32	0.00e+00	1169.00
IUUC-Pab-097975	Pongo abelii	90.11	0.00e+00	1866.00
IUUC-Pca-101127	Procavia capensis	86.96	0.00e+00	1241.00
IUUC-Pva-102431	Pteropus vampyrus	84.63	0.00e+00	1662.00
IUUC-Sha-106690	Sarcophilus harrisii	88.63	0.00e+00	1878.00
IUUC-Ssc-116189	Sus scrofa	92.67	0.00e+00	1829.00
IUUC-Tgu-116527	Taeniopygia guttata	85.40	0.00e+00	1828.00
IUUC-Tru-118389	Takifugu rubripes	62.41	0.00e+00	1225.00
IUUC-Tsy-119193	Tarsius syrichta	90.37	0.00e+00	1814.00
IUUC-Tni-119790	Tetraodon nigroviridis	63.53	0.00e+00	1107.00
IUUC-Tbe-127445	Tupaia belangeri	94.82	0.00e+00	1284.00
IUUC-Ttr-128877	Tursiops truncatus	91.63	0.00e+00	1811.00
IUUC-Xtr-132274	Xenopus tropicalis	77.22	0.00e+00	1582.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence