iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17462600; 18819927; 21179390
UBD/ZnF/Other	UBD/ZnF/Other	23418353

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.70e-09	37.8	228	269

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+ed+  +++++ lpC+H+fh +C+  w         +++CP+Cr
   Q: 228  CPVCKEDYtvEEEVRQLPCNHFFHSSCIVPW------LELHDTCPVCR 269
           ********99777******************......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Protein Sequence
(Fasta)

MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT DDSSFLGGGG 60
SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN RANERGHQTH TDFWGARPPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTTGGTGC TGGGAGGCGG GCCGCAGGGT AGCTGTTGGC GCCGCCGCGT TTCTGGGCCT 60
GGCCAACTCA CGTGACCGAC GCGGGCTCTG AAGCGGTGGG CCGCACCGAG GCGGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

hsa:27246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000079	Aegilops tauschii	30.32	3.00e-24	105.00
IUUC-Aml-002035	Ailuropoda melanoleuca	93.75	2.00e-148	518.00
IUUC-Apl-003694	Anas platyrhynchos	89.16	1.00e-79	289.00
IUUC-Aca-004365	Anolis carolinensis	77.98	9.00e-44	168.00
IUUC-Acl-008247	Aspergillus clavatus	37.33	3.00e-19	89.70
IUUC-Ate-010398	Aspergillus terreus	38.66	1.00e-18	87.80
IUUC-Ame-011898	Astyanax mexicanus	53.52	1.00e-71	263.00
IUUC-Bta-013190	Bos taurus	81.94	3.00e-122	431.00
IUUC-Bci-013958	Botrytis cinerea	37.14	2.00e-17	84.30
IUUC-Bol-016085	Brassica oleracea	41.18	5.00e-28	119.00
IUUC-Bra-016939	Brassica rapa	31.79	3.00e-28	119.00
IUUC-Cja-020001	Callithrix jacchus	95.47	2.00e-151	528.00
IUUC-Cfa-020882	Canis familiaris	93.73	8.00e-148	516.00
IUUC-Cpo-021690	Cavia porcellus	80.22	3.00e-114	404.00
IUUC-Csa-024004	Chlorocebus sabaeus	98.61	9.00e-154	536.00
IUUC-Cho-024643	Choloepus hoffmanni	92.55	3.00e-80	291.00
IUUC-Cin-025452	Ciona intestinalis	39.50	7.00e-19	86.30
IUUC-Csv-025892	Ciona savignyi	36.51	7.00e-21	92.80
IUUC-Dre-027515	Danio rerio	58.68	3.00e-81	295.00
IUUC-Dno-029010	Dasypus novemcinctus	93.40	7.00e-148	516.00
IUUC-Dor-030147	Dipodomys ordii	84.13	1.00e-127	448.00
IUUC-Dse-031376	Dothistroma septosporum	33.57	1.00e-17	84.30
IUUC-Dme-031601	Drosophila melanogaster	54.55	9.00e-35	140.00
IUUC-Ete-032392	Echinops telfairi	90.06	1.00e-78	286.00
IUUC-Eca-033803	Equus caballus	92.62	2.00e-135	475.00
IUUC-Eeu-034831	Erinaceus europaeus	74.74	1.00e-95	343.00
IUUC-Fca-036192	Felis catus	93.40	4.00e-156	543.00
IUUC-Gmo-039513	Gadus morhua	59.56	4.00e-88	317.00
IUUC-Gga-040282	Gallus gallus	79.41	3.00e-76	277.00
IUUC-Ggo-044873	Gorilla gorilla	99.30	2.00e-154	538.00
IUUC-Itr-048142	Ictidomys tridecemlineatus	91.88	2.00e-138	484.00
IUUC-Lch-050673	Latimeria chalumnae	75.78	1.00e-121	429.00
IUUC-Laf-054384	Loxodonta africana	87.50	6.00e-137	479.00
IUUC-Mcc-055137	Macaca mulatta	98.61	9.00e-154	536.00
IUUC-Meu-056635	Macropus eugenii	85.98	4.00e-113	400.00
IUUC-Mtr-058295	Medicago truncatula	30.34	3.00e-24	106.00
IUUC-Mla-058832	Melampsora laricipopulina	46.84	1.00e-14	72.80
IUUC-Mmr-060631	Microcebus murinus	94.79	9.00e-159	552.00
IUUC-Mdo-062489	Monodelphis domestica	87.85	1.00e-127	448.00
IUUC-Mmu-064196	Mus musculus	93.06	6.00e-156	543.00
IUUC-Mac-065133	Musa acuminata	44.25	2.00e-26	112.00
IUUC-Mpu-066575	Mustela putorius furo	93.75	2.00e-156	545.00
IUUC-Mlu-067024	Myotis lucifugus	87.08	2.00e-136	478.00
IUUC-Nle-069348	Nomascus leucogenys	97.56	5.00e-150	523.00
IUUC-Opr-070812	Ochotona princeps	86.46	1.00e-141	495.00
IUUC-Ont-072238	Oreochromis niloticus	46.84	2.00e-61	228.00
IUUC-Ocu-074691	Oryctolagus cuniculus	94.79	2.00e-145	508.00
IUUC-Oin-079595	Oryza indica	50.00	3.00e-21	97.40
IUUC-Ola-087047	Oryzias latipes	61.72	1.00e-90	325.00
IUUC-Oga-089111	Otolemur garnettii	92.73	6.00e-140	489.00
IUUC-Oar-089999	Ovis aries	81.94	1.00e-122	433.00
IUUC-Ptr-091473	Pan troglodytes	98.95	7.00e-154	536.00
IUUC-Pan-092618	Papio anubis	85.37	2.00e-124	438.00
IUUC-Psi-093930	Pelodiscus sinensis	81.38	7.00e-114	403.00
IUUC-Pma-094530	Petromyzon marinus	47.19	3.00e-59	221.00
IUUC-Pno-094903	Phaeosphaeria nodorum	41.88	6.00e-18	85.50
IUUC-Pfo-096461	Poecilia formosa	69.09	2.00e-64	239.00
IUUC-Pab-098466	Pongo abelii	99.30	9.00e-155	539.00
IUUC-Pca-100550	Procavia capensis	73.61	1.00e-106	379.00
IUUC-Pva-102881	Pteropus vampyrus	89.58	3.00e-142	497.00
IUUC-Rno-104914	Rattus norvegicus	93.40	2.00e-156	544.00
IUUC-Sha-107616	Sarcophilus harrisii	87.45	3.00e-115	407.00
IUUC-Sja-107922	Schizosaccharomyces japonicus	41.04	7.00e-24	105.00
IUUC-Spo-108354	Schizosaccharomyces pombe	36.08	3.00e-26	113.00
IUUC-Smo-109522	Selaginella moellendorffii	51.43	5.00e-20	88.60
IUUC-Sar-113319	Sorex araneus	70.37	3.00e-61	228.00
IUUC-Sre-115230	Sporisorium reilianum	38.79	1.00e-17	85.10
IUUC-Ssc-115917	Sus scrofa	83.33	1.00e-127	449.00
IUUC-Tgu-117105	Taeniopygia guttata	90.55	4.00e-67	246.00
IUUC-Tru-118087	Takifugu rubripes	48.71	1.00e-60	226.00
IUUC-Tsy-119630	Tarsius syrichta	84.56	5.00e-133	466.00
IUUC-Tni-120265	Tetraodon nigroviridis	63.79	2.00e-94	338.00
IUUC-Tae-124758	Triticum aestivum	49.50	9.00e-22	97.80
IUUC-Tur-126410	Triticum urartu	42.31	8.00e-15	73.90
IUUC-Tme-127143	Tuber melanosporum	47.75	5.00e-28	118.00
IUUC-Tbe-127794	Tupaia belangeri	71.31	4.00e-94	337.00
IUUC-Ttr-129117	Tursiops truncatus	81.25	1.00e-116	412.00
IUUC-Uma-129414	Ustilago maydis	36.67	1.00e-17	85.10
IUUC-Vpa-130755	Vicugna pacos	80.81	3.00e-110	390.00
IUUC-Xtr-132520	Xenopus tropicalis	72.99	7.00e-97	346.00
IUUC-Xma-133074	Xiphophorus maculatus	68.48	4.00e-64	238.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence