iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001661

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01115370

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000008969.1	ENSAMET00000009876.1	ENSAMEP00000009468.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-109	365.1	778	1108

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 778  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 864
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 865  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 951
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c+ ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 952  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRTRRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1033
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1034 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1108
           ***********9988...69*************************88888*******************...********8 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTRNYVQSA LKIFKTAEEC RLDRDEERAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GLANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTGCTG TGGCTTCAGT TCCTAAAGAA CTCTACCTCA GTTCTTCCCT GAAAGACCTT 60
AATAAGAAGA CAGAAGTTAA ACCAGAGAAA ATAAGCACGA GGAAGTATGT ATCCTTTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003226	Anas platyrhynchos	64.25	0.00e+00	1346.00
IUUC-Aca-004936	Anolis carolinensis	65.60	0.00e+00	1293.00
IUUC-Ago-007959	Ashbya gossypii	35.62	2.00e-54	207.00
IUUC-Acl-008102	Aspergillus clavatus	31.32	2.00e-50	194.00
IUUC-Afl-008604	Aspergillus flavus	32.05	2.00e-49	191.00
IUUC-Afu-009001	Aspergillus fumigatus	31.11	1.00e-49	192.00
IUUC-Ani-009291	Aspergillus nidulans	31.16	2.00e-49	191.00
IUUC-Ang-009844	Aspergillus niger	32.43	1.00e-48	188.00
IUUC-Aor-010098	Aspergillus oryzae	32.05	8.00e-49	189.00
IUUC-Ate-010585	Aspergillus terreus	31.64	8.00e-49	189.00
IUUC-Ame-011029	Astyanax mexicanus	61.67	7.00e-75	273.00
IUUC-Bta-013008	Bos taurus	89.82	0.00e+00	1832.00
IUUC-Bol-015281	Brassica oleracea	38.21	6.00e-47	181.00
IUUC-Bra-017228	Brassica rapa	39.10	1.00e-48	187.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	8.00e-52	198.00
IUUC-Cja-019173	Callithrix jacchus	90.54	0.00e+00	1885.00
IUUC-Cfa-021243	Canis familiaris	96.96	0.00e+00	2000.00
IUUC-Cpo-021522	Cavia porcellus	84.91	0.00e+00	1726.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	4.00e-82	297.00
IUUC-Csa-023616	Chlorocebus sabaeus	92.14	0.00e+00	1604.00
IUUC-Cho-024381	Choloepus hoffmanni	77.44	0.00e+00	1542.00
IUUC-Cin-025287	Ciona intestinalis	50.13	2.00e-99	357.00
IUUC-Csv-026253	Ciona savignyi	47.79	7.00e-88	318.00
IUUC-Cne-026821	Cryptococcus neoformans	40.17	5.00e-75	276.00
IUUC-Dre-028440	Danio rerio	69.00	0.00e+00	735.00
IUUC-Dno-029039	Dasypus novemcinctus	90.37	0.00e+00	1915.00
IUUC-Dor-031043	Dipodomys ordii	96.12	3.00e-133	469.00
IUUC-Dse-031463	Dothistroma septosporum	28.07	6.00e-41	162.00
IUUC-Dme-032089	Drosophila melanogaster	44.50	2.00e-85	310.00
IUUC-Ete-033040	Echinops telfairi	81.48	0.00e+00	1531.00
IUUC-Eca-033449	Equus caballus	93.93	0.00e+00	1938.00
IUUC-Eeu-034693	Erinaceus europaeus	96.12	7.00e-132	464.00
IUUC-Fca-035794	Felis catus	99.79	0.00e+00	941.00
IUUC-Fal-037322	Ficedula albicollis	69.09	0.00e+00	1427.00
IUUC-Gmo-038584	Gadus morhua	66.46	0.00e+00	659.00
IUUC-Gga-041188	Gallus gallus	83.36	0.00e+00	932.00
IUUC-Gac-041850	Gasterosteus aculeatus	72.46	0.00e+00	736.00
IUUC-Ggo-045565	Gorilla gorilla	91.97	0.00e+00	1924.00
IUUC-Hsa-046438	Homo sapiens	91.88	0.00e+00	1919.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	89.46	0.00e+00	1840.00
IUUC-Kpa-049321	Komagataella pastoris	33.24	5.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	79.85	0.00e+00	868.00
IUUC-Loc-052769	Lepisosteus oculatus	71.88	0.00e+00	776.00
IUUC-Lma-053021	Leptosphaeria maculans	33.04	3.00e-53	204.00
IUUC-Laf-053432	Loxodonta africana	78.20	0.00e+00	1699.00
IUUC-Mcc-055823	Macaca mulatta	91.44	0.00e+00	1916.00
IUUC-Meu-056099	Macropus eugenii	97.77	1.00e-165	577.00
IUUC-Mla-059089	Melampsora laricipopulina	40.18	5.00e-72	266.00
IUUC-Mga-059739	Meleagris gallopavo	83.19	0.00e+00	929.00
IUUC-Mvi-060559	Microbotryum violaceum	41.14	1.00e-77	285.00
IUUC-Mmr-061158	Microcebus murinus	90.54	0.00e+00	1850.00
IUUC-Mdo-061801	Monodelphis domestica	79.88	0.00e+00	1585.00
IUUC-Mmu-063665	Mus musculus	81.52	0.00e+00	1680.00
IUUC-Mpu-066738	Mustela putorius furo	96.70	0.00e+00	1962.00
IUUC-Mlu-067307	Myotis lucifugus	90.20	0.00e+00	1852.00
IUUC-Nfi-068410	Neosartorya fischeri	31.39	5.00e-50	193.00
IUUC-Nle-069314	Nomascus leucogenys	91.53	0.00e+00	1909.00
IUUC-Opr-070378	Ochotona princeps	80.88	0.00e+00	1220.00
IUUC-Ont-071545	Oreochromis niloticus	76.42	0.00e+00	763.00
IUUC-Oan-073537	Ornithorhynchus anatinus	76.37	0.00e+00	1533.00
IUUC-Ocu-074193	Oryctolagus cuniculus	89.02	0.00e+00	1843.00
IUUC-Ola-086622	Oryzias latipes	75.05	0.00e+00	740.00
IUUC-Oga-088271	Otolemur garnettii	88.16	0.00e+00	1800.00
IUUC-Oar-090431	Ovis aries	90.54	0.00e+00	1861.00
IUUC-Ptr-091339	Pan troglodytes	91.61	0.00e+00	1967.00
IUUC-Pan-091783	Papio anubis	86.11	0.00e+00	981.00
IUUC-Psi-093187	Pelodiscus sinensis	64.40	0.00e+00	991.00
IUUC-Pma-094626	Petromyzon marinus	58.43	1.00e-141	496.00
IUUC-Pfo-096463	Poecilia formosa	75.41	0.00e+00	753.00
IUUC-Pab-097645	Pongo abelii	91.61	0.00e+00	1913.00
IUUC-Pva-103222	Pteropus vampyrus	86.10	0.00e+00	958.00
IUUC-Pgr-103408	Puccinia graminis	35.92	2.00e-54	207.00
IUUC-Ptt-103699	Puccinia triticina	45.45	2.00e-67	251.00
IUUC-Pte-104348	Pyrenophora teres	28.83	2.00e-39	157.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.11	1.00e-50	195.00
IUUC-Rno-105510	Rattus norvegicus	81.16	0.00e+00	1695.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.26	3.00e-51	197.00
IUUC-Sha-106879	Sarcophilus harrisii	79.47	0.00e+00	1564.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	4.00e-48	186.00
IUUC-Sar-113019	Sorex araneus	85.19	0.00e+00	1784.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	1.00e-68	255.00
IUUC-Ssc-116334	Sus scrofa	90.20	0.00e+00	1877.00
IUUC-Tgu-117062	Taeniopygia guttata	81.21	0.00e+00	917.00
IUUC-Tru-117908	Takifugu rubripes	57.86	0.00e+00	1163.00
IUUC-Tsy-118867	Tarsius syrichta	87.92	0.00e+00	1089.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.65	0.00e+00	731.00
IUUC-Tme-127144	Tuber melanosporum	40.00	1.00e-78	288.00
IUUC-Tbe-127877	Tupaia belangeri	88.48	2.00e-105	377.00
IUUC-Ttr-128580	Tursiops truncatus	88.39	0.00e+00	1779.00
IUUC-Uma-129340	Ustilago maydis	35.75	6.00e-71	263.00
IUUC-Vpa-130541	Vicugna pacos	92.41	0.00e+00	1914.00
IUUC-Xtr-132161	Xenopus tropicalis	58.68	0.00e+00	1191.00
IUUC-Xma-134271	Xiphophorus maculatus	75.41	0.00e+00	751.00
IUUC-Yli-134561	Yarrowia lipolytica	35.92	7.00e-60	225.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence