iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18698375; 15331760

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.00e-07	31.4	57	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf................kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC++++                ++ +  + C+H+fh +C+ +w       +++  CPl+
   Q: 57   CAICRNHImnlciecqadpnanqdECTVAWGECNHAFHYHCIARW------LKTRLVCPLD 111
           ********555555554444443322244588*************......********97 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity).

Protein Sequence
(Fasta)

MAEEIEVEET EDFHDMDFND EEPSCSGGAV QARTERFVVK KWVAHAMWGW DVAVDNCAIC 60
RNHIMNLCIE CQADPNANQD ECTVAWGECN HAFHYHCIAR WLKTRLVCPL DNKEWVYQKY 120

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Nucleotide Sequence
(Fasta)

AAAATAAGTG TTGTATTTTG AAAAAGAAAA AAAATTCGTA ATTTCACACC ATGGCCGAGG 60
AGATAGAGGT TGAGGAGACG GAGGACTTCC ACGACATGGA CTTCAATGAC GAAGAGCCAT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008283--P:cell proliferation
GO:0030317--P:flagellated sperm motility
GO:0019915--P:lipid storage
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG16988

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence