iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046243

Ensembl Protein ID

ENSP00000483825.1

UniProt Accession

Q9Y6K9; Q7LBY6; Q7Z7F1; NEMO_HUMAN

Genbank Protein ID

AAD12183.1; AAD38081.1; AAC36330.1; CAB93146.1; AAF99679.1; AAM44073.1; AAV38427.1; AAL27012.1; AAH00299.1; AAH12114.1; AAH46922.1; AAH50612.1

Protein Name

NF-kappa-B essential modulator; FIP-3; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NF-kappa-B essential modifier

Genbank Nucleotide ID

AF062089; AF091453; AF074382; AJ271718; AF261086; AY114157; AK000593; AF277315; BC000299; BC012114; BC046922; BC050612

Gene Name

IKBKG; FIP3; NEMO

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000269335.5	ENST00000618670.4	ENSP00000483825.1
ENSG00000269335.5	ENST00000612051.1	ENSP00000480431.1
ENSG00000269335.5	ENST00000619941.4	ENSP00000478979.1
ENSG00000269335.5	ENST00000615874.4	ENSP00000483381.1
ENSG00000269335.5	ENST00000617207.4	ENSP00000484023.1
ENSG00000269335.5	ENST00000611176.4	ENSP00000478616.1
ENSG00000269335.5	ENST00000492469.2	ENSP00000484275.1

Annotation

Cancer Mutation
TCGA	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	TCGA	ICGC	THPA
HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/Other	UBD/ZnF/Other	19854139; 19854204; 18313693
UBD/Alpha-Helix/UBAN	UBAN	18212736; 23746843; 24100029; 22605335

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBAN	2.90e-26	92.9	359	418

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +++++etv+vLk+Q++iYk+DFqaER++RE+l+e+ke Lqeq+e+lq+++skl++s+++s
   Q: 359  HKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQES 418
           899*******************************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

Protein Sequence
(Fasta)

MALVIQVGKL RPREVRTPQT INPSLFPSLP VKLSSIIEVP SGGERCCSRR TLVYKARAFW 60
KGAPLPCWMN RHLWKSQLCE MVQPSGGPAA DQDVLGEESP LGKPAMLHLP SEQGAPETLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGACTCCA GAAAGGTACT GGTGGCAGGG GACTGGTCTG CTGAGTCACA GCAACCCCAC 60
GCTCCAGGCC GTTTGTTCCT GCTGCTCCCT TTGGGATTAA CTAGAGATTG AACCGGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0227--DNA damage
KW-0038--Ectodermal dysplasia
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0987--Osteopetrosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0008385--C:IkappaB kinase complex
GO:0005622--C:intracellular
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990450--F:linear polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0004871--F:signal transducer activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000187--P:activation of MAPK activity
GO:0043276--P:anoikis
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006915--P:apoptotic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051650--P:establishment of vesicle localization
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0007254--P:JNK cascade
GO:1901215--P:negative regulation of neuron death
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016239--P:positive regulation of macroautophagy
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0009615--P:response to virus
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0006351--P:transcription, DNA-templated
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway

KEGG

hsa:8517

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002336	Ailuropoda melanoleuca	92.43	0.00e+00	647.00
IUUC-Atr-002599	Amborella trichopoda	39.56	3.00e-03	37.00
IUUC-Aca-004653	Anolis carolinensis	61.56	2.00e-103	369.00
IUUC-Bta-012778	Bos taurus	85.68	2.00e-176	611.00
IUUC-Cja-018954	Callithrix jacchus	95.13	0.00e+00	699.00
IUUC-Cfa-020778	Canis familiaris	89.81	0.00e+00	689.00
IUUC-Cpo-022327	Cavia porcellus	86.67	2.00e-150	525.00
IUUC-Csa-023340	Chlorocebus sabaeus	98.39	5.00e-177	613.00
IUUC-Dre-028819	Danio rerio	45.59	1.00e-54	207.00
IUUC-Dno-029566	Dasypus novemcinctus	86.22	2.00e-163	568.00
IUUC-Dor-031122	Dipodomys ordii	62.40	2.00e-35	142.00
IUUC-Dme-032072	Drosophila melanogaster	26.69	2.00e-03	37.00
IUUC-Eca-033895	Equus caballus	84.16	4.00e-152	531.00
IUUC-Eeu-034478	Erinaceus europaeus	90.24	6.00e-89	321.00
IUUC-Fca-035990	Felis catus	93.03	3.00e-124	438.00
IUUC-Gmo-038622	Gadus morhua	46.50	8.00e-55	208.00
IUUC-Gac-041917	Gasterosteus aculeatus	50.00	8.00e-57	214.00
IUUC-Ggo-045478	Gorilla gorilla	99.18	0.00e+00	791.00
IUUC-Itr-048520	Ictidomys tridecemlineatus	89.36	0.00e+00	642.00
IUUC-Lch-050187	Latimeria chalumnae	57.64	4.00e-104	371.00
IUUC-Loc-052627	Lepisosteus oculatus	55.10	9.00e-63	234.00
IUUC-Laf-054387	Loxodonta africana	87.06	4.00e-149	521.00
IUUC-Mcc-054611	Macaca mulatta	96.92	0.00e+00	768.00
IUUC-Meu-056530	Macropus eugenii	64.92	3.00e-97	348.00
IUUC-Mmr-061028	Microcebus murinus	84.04	0.00e+00	690.00
IUUC-Mdo-062520	Monodelphis domestica	64.75	5.00e-121	427.00
IUUC-Mmu-063925	Mus musculus	85.92	1.00e-167	582.00
IUUC-Mpu-066392	Mustela putorius furo	87.59	5.00e-162	563.00
IUUC-Mlu-067374	Myotis lucifugus	84.15	1.00e-156	546.00
IUUC-Nle-069085	Nomascus leucogenys	98.27	8.00e-95	338.00
IUUC-Ont-071385	Oreochromis niloticus	47.04	2.00e-56	213.00
IUUC-Oan-073347	Ornithorhynchus anatinus	71.03	7.00e-147	513.00
IUUC-Ocu-074929	Oryctolagus cuniculus	87.86	0.00e+00	633.00
IUUC-Ola-086340	Oryzias latipes	48.68	3.00e-60	226.00
IUUC-Oga-088042	Otolemur garnettii	92.14	0.00e+00	656.00
IUUC-Oar-090051	Ovis aries	87.89	2.00e-168	585.00
IUUC-Ptr-090498	Pan troglodytes	98.77	0.00e+00	785.00
IUUC-Psi-093840	Pelodiscus sinensis	67.10	2.00e-86	313.00
IUUC-Pfo-097140	Poecilia formosa	42.52	2.00e-48	187.00
IUUC-Pab-097707	Pongo abelii	98.36	0.00e+00	785.00
IUUC-Pca-100427	Procavia capensis	68.67	1.00e-137	483.00
IUUC-Pva-102328	Pteropus vampyrus	82.80	1.00e-152	532.00
IUUC-Ptt-103739	Puccinia triticina	21.76	6.60e-02	32.70
IUUC-Pte-104119	Pyrenophora teres	29.33	1.50e-01	32.00
IUUC-Rno-105231	Rattus norvegicus	87.35	0.00e+00	634.00
IUUC-Sha-106676	Sarcophilus harrisii	74.18	2.00e-153	535.00
IUUC-Stu-112545	Solanum tuberosum	31.11	5.60e-02	32.30
IUUC-Sar-113027	Sorex araneus	72.65	5.00e-68	250.00
IUUC-Ssc-116284	Sus scrofa	89.02	5.00e-154	537.00
IUUC-Tru-117790	Takifugu rubripes	45.13	2.00e-49	191.00
IUUC-Tbe-127949	Tupaia belangeri	91.33	1.00e-64	240.00
IUUC-Ttr-128663	Tursiops truncatus	87.50	2.00e-166	578.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence