iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/DWNN	DWNN	15733535

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.10e-06	28.7	210	284
E3 activity/RING/RING	0.12	12.9	217	258
ULD/UDP/UFD/DWNN	4.30e-42	142.3	3	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggk.tcPvtrqpl.teedlvPnltlrrliqawceen 72
           e+pe+++C I  +++ d v++p +G ++   +++  l +++  +cP ++++  ++ +l+Pn +lr+ ++a+ +e 
   Q: 210  EIPEDLICGICRDIFVDAVMIPcCGSSFCDDCVRTSLLESEDsECPDCKEKNcSPGSLIPNRFLRNSVNAFKNET 284
           69*******************************99996655559****99987****************998775 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ f d ++  p Cg  f+ dC+      + ++s    CP C+
   Q: 217  CGICRDIFVDAVM-IPcCGSSFCDDCV----RTSLLESEDSECPDCK 258
           9*******99566.554899******7....44467999999***96 PP

ULD/UDP/UFD/DWNN

   S: 1    vhykfksklnydtitfDGlhisvfDLkreiiqrekLgkaaDfdLqitnaqtkeeykDDafliPkntsvivkriP 74
           vhykfks+ln+dtitfDGlhisv+DLkrei+q+++Lgk++DfdLqitnaq+keeykDD+fliPknt++i++riP
   Q: 3    VHYKFKSTLNFDTITFDGLHISVGDLKREIVQQKRLGKIIDFDLQITNAQSKEEYKDDGFLIPKNTTLIISRIP 76
           8************************************************************************9 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSVHYKFKST LNFDTITFDG LHISVGDLKR EIVQQKRLGK IIDFDLQITN AQSKEEYKDD 60
GFLIPKNTTL IISRIPIAHP TKKGWEPPAA ENAFSAAPAK QDNFNMDLSK MQGTEEDKIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCATTTCA CATCTCTGGG GCTTTGGCGT CACGTTCGCA TCTCTAGTAA ATTGGAAAAA 60
AATAAAATCG TCGGAGTTTT TATGTGCTTG CAGAGTAGTG TAAGTAATTG CTATTTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR014891--DWNN_domain
IPR001878--Znf_CCHC
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51282--DWNN
PS50158--ZF_CCHC
PS50089--ZF_RING_2

Pfam

PF08783--DWNN

SMART

SM01180--DWNN

Gene Ontology

GO:0005634--C:nucleus
GO:0003676--F:nucleic acid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0035736--P:cell proliferation involved in compound eye morphogenesis
GO:0022008--P:neurogenesis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000195	Aegilops tauschii	50.70	6.00e-17	82.00
IUUC-Aml-001655	Ailuropoda melanoleuca	42.17	8.00e-71	262.00
IUUC-Atr-002718	Amborella trichopoda	43.37	5.00e-18	85.90
IUUC-Apl-004100	Anas platyrhynchos	39.07	7.00e-49	189.00
IUUC-Aca-004345	Anolis carolinensis	39.00	2.00e-36	147.00
IUUC-Aly-006444	Arabidopsis lyrata	29.61	2.00e-35	143.00
IUUC-Ath-007648	Arabidopsis thaliana	29.40	1.00e-34	141.00
IUUC-Ago-007949	Ashbya gossypii	31.90	3.00e-21	95.10
IUUC-Acl-008118	Aspergillus clavatus	28.70	2.00e-26	113.00
IUUC-Afl-008408	Aspergillus flavus	53.70	3.00e-10	58.90
IUUC-Afu-008777	Aspergillus fumigatus	30.05	5.00e-30	125.00
IUUC-Ani-009426	Aspergillus nidulans	29.12	1.00e-34	140.00
IUUC-Ang-009735	Aspergillus niger	29.83	6.00e-31	128.00
IUUC-Aor-010213	Aspergillus oryzae	31.66	2.00e-29	123.00
IUUC-Ate-010474	Aspergillus terreus	32.25	1.00e-27	117.00
IUUC-Ame-010679	Astyanax mexicanus	43.79	2.00e-74	274.00
IUUC-Bgr-012229	Blumeria graminis	30.06	6.00e-29	121.00
IUUC-Bta-012672	Bos taurus	42.12	2.00e-70	260.00
IUUC-Bci-013880	Botrytis cinerea	29.64	4.00e-25	108.00
IUUC-Bdi-014276	Brachypodium distachyon	30.97	2.00e-23	103.00
IUUC-Bol-015602	Brassica oleracea	29.69	5.00e-35	142.00
IUUC-Bra-016670	Brassica rapa	28.37	6.00e-32	132.00
IUUC-Cel-018532	Caenorhabditis elegans	32.29	1.00e-44	174.00
IUUC-Cja-018843	Callithrix jacchus	39.93	7.00e-56	212.00
IUUC-Cfa-021107	Canis familiaris	42.12	6.00e-71	262.00
IUUC-Cre-022712	Chlamydomonas reinhardtii	39.19	5.00e-12	65.10
IUUC-Csa-023397	Chlorocebus sabaeus	42.42	7.00e-71	262.00
IUUC-Cho-024327	Choloepus hoffmanni	41.82	7.00e-68	252.00
IUUC-Cin-025439	Ciona intestinalis	35.45	6.00e-26	109.00
IUUC-Csv-026162	Ciona savignyi	34.47	5.00e-30	123.00
IUUC-Cgl-026629	Colletotrichum gloeosporioides	28.93	3.00e-22	99.40
IUUC-Cne-026921	Cryptococcus neoformans	31.00	1.00e-20	94.40
IUUC-Cme-027244	Cyanidioschyzon merolae	27.67	6.00e-20	92.40
IUUC-Dre-028023	Danio rerio	45.32	6.00e-77	282.00
IUUC-Dno-029430	Dasypus novemcinctus	46.50	2.00e-42	168.00
IUUC-Dor-030406	Dipodomys ordii	34.47	9.00e-35	142.00
IUUC-Dse-031312	Dothistroma septosporum	28.21	9.00e-26	110.00
IUUC-Ete-032466	Echinops telfairi	38.15	1.00e-31	132.00
IUUC-Eca-033447	Equus caballus	40.44	1.00e-60	225.00
IUUC-Eeu-034677	Erinaceus europaeus	36.96	1.00e-47	185.00
IUUC-Fca-035439	Felis catus	42.12	1.00e-70	261.00
IUUC-Fal-037230	Ficedula albicollis	41.45	3.00e-71	263.00
IUUC-Fox-037976	Fusarium oxysporum	31.96	1.00e-32	133.00
IUUC-Fso-038202	Fusarium solani	31.01	3.00e-31	129.00
IUUC-Gmo-039390	Gadus morhua	38.81	7.00e-36	142.00
IUUC-Ggr-040035	Gaeumannomyces graminis	28.06	3.00e-23	102.00
IUUC-Gga-040908	Gallus gallus	40.87	2.00e-70	261.00
IUUC-Gac-041718	Gasterosteus aculeatus	37.80	7.00e-37	146.00
IUUC-Gma-044202	Glycine max	55.26	6.00e-21	95.50
IUUC-Ggo-044567	Gorilla gorilla	43.33	3.00e-70	260.00
IUUC-Hsa-046849	Homo sapiens	42.42	6.00e-71	262.00
IUUC-Hvu-047515	Hordeum vulgare	50.70	3.00e-17	81.30
IUUC-Itr-048832	Ictidomys tridecemlineatus	41.82	3.00e-70	260.00
IUUC-Kpa-049323	Komagataella pastoris	25.73	2.00e-20	92.80
IUUC-Lch-050524	Latimeria chalumnae	43.07	3.00e-73	270.00
IUUC-Lpe-050947	Leersia perrieri	25.92	1.00e-25	110.00
IUUC-Loc-052709	Lepisosteus oculatus	42.81	7.00e-70	259.00
IUUC-Lma-053186	Leptosphaeria maculans	28.12	7.00e-25	108.00
IUUC-Laf-054472	Loxodonta africana	42.12	2.00e-70	261.00
IUUC-Mcc-055743	Macaca mulatta	42.42	7.00e-71	262.00
IUUC-Meu-056399	Macropus eugenii	45.00	6.00e-36	146.00
IUUC-Mor-057073	Magnaporthe oryzae	27.81	2.00e-23	103.00
IUUC-Mpo-057378	Magnaporthe poae	28.31	3.00e-23	102.00
IUUC-Mtr-057755	Medicago truncatula	29.01	5.00e-27	115.00
IUUC-Mla-058840	Melampsora laricipopulina	48.65	6.00e-18	85.10
IUUC-Mga-060129	Meleagris gallopavo	37.99	4.00e-49	189.00
IUUC-Mvi-060424	Microbotryum violaceum	28.95	1.00e-12	67.80
IUUC-Mmr-061295	Microcebus murinus	41.49	4.00e-71	263.00
IUUC-Mdo-062295	Monodelphis domestica	39.17	7.00e-40	159.00
IUUC-Mmu-064009	Mus musculus	42.47	9.00e-72	265.00
IUUC-Mac-065479	Musa acuminata	29.08	8.00e-35	141.00
IUUC-Mpu-065875	Mustela putorius furo	42.47	2.00e-71	264.00
IUUC-Mlu-066941	Myotis lucifugus	42.47	1.00e-71	265.00
IUUC-Nfi-068518	Neosartorya fischeri	30.22	3.00e-30	125.00
IUUC-Ncr-068886	Neurospora crassa	30.55	9.00e-28	117.00
IUUC-Nle-069717	Nomascus leucogenys	42.47	3.00e-71	263.00
IUUC-Opr-070280	Ochotona princeps	40.26	2.00e-60	228.00
IUUC-Ont-071462	Oreochromis niloticus	40.00	3.00e-69	257.00
IUUC-Oan-073300	Ornithorhynchus anatinus	43.19	1.00e-41	165.00
IUUC-Ocu-074124	Oryctolagus cuniculus	42.12	2.00e-70	261.00
IUUC-Oba-075756	Oryza barthii	25.84	3.00e-26	113.00
IUUC-Obr-076580	Oryza brachyantha	50.70	7.00e-17	82.00
IUUC-Ogl-077759	Oryza glaberrima	27.73	8.00e-32	131.00
IUUC-Ogu-078657	Oryza glumaepatula	25.84	2.00e-25	110.00
IUUC-Oin-079481	Oryza indica	27.30	3.00e-28	119.00
IUUC-Olo-081062	Oryza longistaminata	50.70	7.00e-17	81.60
IUUC-Ome-081813	Oryza meridionalis	26.12	3.00e-26	113.00
IUUC-Oni-083007	Oryza nivara	26.32	8.00e-26	111.00
IUUC-Opu-083385	Oryza punctata	25.84	1.00e-25	111.00
IUUC-Oru-084861	Oryza rufipogon	25.84	8.00e-26	111.00
IUUC-Osa-085896	Oryza sativa	27.73	4.00e-32	131.00
IUUC-Ola-086693	Oryzias latipes	37.06	9.00e-59	221.00
IUUC-Olu-087631	Ostreococcus lucimarinus	49.33	3.00e-16	75.50
IUUC-Oga-088262	Otolemur garnettii	42.12	2.00e-70	260.00
IUUC-Oar-089658	Ovis aries	42.12	2.00e-70	261.00
IUUC-Ptr-091311	Pan troglodytes	42.68	1.00e-71	265.00
IUUC-Pan-091925	Papio anubis	42.12	1.00e-70	261.00
IUUC-Psi-093605	Pelodiscus sinensis	37.04	4.00e-48	187.00
IUUC-Pma-094163	Petromyzon marinus	39.13	6.00e-38	149.00
IUUC-Pno-094790	Phaeosphaeria nodorum	29.76	2.00e-11	63.50
IUUC-Ppa-095943	Physcomitrella patens	30.73	6.00e-44	172.00
IUUC-Pfo-096581	Poecilia formosa	39.76	1.00e-67	251.00
IUUC-Pab-098229	Pongo abelii	42.42	4.00e-71	263.00
IUUC-Pop-099598	Populus trichocarpa	30.14	7.00e-37	148.00
IUUC-Pca-100875	Procavia capensis	38.30	7.00e-27	116.00
IUUC-Ppe-101658	Prunus persica	55.26	2.00e-21	97.10
IUUC-Pva-102343	Pteropus vampyrus	42.17	1.00e-70	261.00
IUUC-Pgr-103275	Puccinia graminis	48.65	1.00e-17	84.70
IUUC-Pte-104161	Pyrenophora teres	27.67	3.00e-11	62.80
IUUC-Pyt-104576	Pyrenophora triticirepentis	27.67	2.00e-11	63.20
IUUC-Rno-105264	Rattus norvegicus	42.17	1.00e-71	264.00
IUUC-Sce-106138	Saccharomyces cerevisiae	27.61	1.00e-26	113.00
IUUC-Sha-107497	Sarcophilus harrisii	42.17	1.00e-70	261.00
IUUC-Sja-107991	Schizosaccharomyces japonicus	31.18	2.00e-38	152.00
IUUC-Spo-108257	Schizosaccharomyces pombe	32.34	2.00e-38	152.00
IUUC-Ssl-108581	Sclerotinia sclerotiorum	29.07	1.00e-27	117.00
IUUC-Smo-109358	Selaginella moellendorffii	27.15	7.00e-28	117.00
IUUC-Sit-109920	Setaria italica	30.42	3.00e-31	129.00
IUUC-Sly-111905	Solanum lycopersicum	29.58	1.00e-23	103.00
IUUC-Stu-112648	Solanum tuberosum	27.30	2.00e-16	79.30
IUUC-Sar-113120	Sorex araneus	39.72	9.00e-45	175.00
IUUC-Sbi-113881	Sorghum bicolor	50.70	2.00e-17	83.60
IUUC-Sre-115127	Sporisorium reilianum	51.90	2.00e-20	93.20
IUUC-Ssc-116147	Sus scrofa	42.47	1.00e-71	264.00
IUUC-Tgu-117215	Taeniopygia guttata	38.35	8.00e-50	192.00
IUUC-Tru-118525	Takifugu rubripes	40.92	3.00e-68	251.00
IUUC-Tsy-119160	Tarsius syrichta	42.12	1.00e-70	261.00
IUUC-Tni-119816	Tetraodon nigroviridis	40.30	6.00e-38	149.00
IUUC-Tca-121727	Theobroma cacao	30.99	2.00e-30	127.00
IUUC-Tre-122181	Trichoderma reesei	29.55	2.00e-30	126.00
IUUC-Tvi-122316	Trichoderma virens	29.55	7.00e-31	127.00
IUUC-Tae-125622	Triticum aestivum	50.70	3.00e-17	83.20
IUUC-Tur-126827	Triticum urartu	50.91	9.00e-11	61.60
IUUC-Tme-126984	Tuber melanosporum	29.62	2.00e-35	143.00
IUUC-Tbe-127263	Tupaia belangeri	63.51	9.00e-24	105.00
IUUC-Ttr-128498	Tursiops truncatus	41.27	1.00e-69	258.00
IUUC-Uma-129457	Ustilago maydis	50.62	3.00e-20	92.40
IUUC-Vda-129986	Verticillium dahliae	29.80	7.00e-32	131.00
IUUC-Vpa-130795	Vicugna pacos	32.93	8.00e-33	135.00
IUUC-Vvi-131146	Vitis vinifera	55.26	9.00e-22	98.20
IUUC-Xtr-132789	Xenopus tropicalis	43.20	2.00e-70	261.00
IUUC-Xma-133011	Xiphophorus maculatus	39.59	5.00e-66	244.00
IUUC-Yli-134516	Yarrowia lipolytica	28.03	9.00e-24	103.00
IUUC-Zma-134699	Zea mays	52.11	1.00e-17	84.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence