iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074176

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAGW02044171

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000007946.3	ENSOCUT00000007948.3	ENSOCUP00000006868.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.30e-169	564.1	3	728

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeeskpssgkspvgleasrasaapdgthtdgvedvagscpqalahsppgkpklvvkppgsslngvppt 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  papivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrpphqysddeddyeddeedevqntnsairykrkgpgkpgplsgsadgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsvplsiktssgagspavavpahsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddsllrvdcirynravrdlgpvistgllhladdgvlsplaltesgkgsspsvrpsqgsqgssspeekevvettdsrektgla 616
           ***************************************************************************************** PP
   S: 260  .............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvn 335
                        keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv+
   Q: 617  rpgeplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS 705
           ***************************************************************************************** PP
   S: 336  egrlakqrkqgrekkirplkrkr 358
           +grl+kqrk++r+k++rp+k+kr
   Q: 706  IGRLHKQRKPDRRKRSRPYKAKR 728
           *********************98 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATAAGG GCTGGCTGGA GCTGGAGAGC GATCCGGGTG AGGAGGGGGC CGGGTGGGCC 60
AGGGACTGGG GAGGCCGTAT GGGCTTGGGA TGCCCCTGCC TGACCACCCC CCGCGTCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	94.02	0.00e+00	1204.00
IUUC-Apl-003405	Anas platyrhynchos	69.61	0.00e+00	630.00
IUUC-Aca-004836	Anolis carolinensis	79.26	0.00e+00	1130.00
IUUC-Ame-011946	Astyanax mexicanus	63.89	0.00e+00	879.00
IUUC-Bta-013131	Bos taurus	90.96	0.00e+00	1060.00
IUUC-Cja-019599	Callithrix jacchus	95.06	0.00e+00	1293.00
IUUC-Cfa-021003	Canis familiaris	95.47	0.00e+00	1197.00
IUUC-Cpo-022143	Cavia porcellus	94.51	0.00e+00	1273.00
IUUC-Csa-023477	Chlorocebus sabaeus	95.20	0.00e+00	1270.00
IUUC-Cho-024734	Choloepus hoffmanni	81.64	0.00e+00	737.00
IUUC-Csv-025842	Ciona savignyi	57.33	5.00e-94	337.00
IUUC-Dre-027793	Danio rerio	65.03	0.00e+00	908.00
IUUC-Dno-029253	Dasypus novemcinctus	94.29	0.00e+00	1258.00
IUUC-Dor-030891	Dipodomys ordii	87.38	0.00e+00	1172.00
IUUC-Dme-031796	Drosophila melanogaster	61.19	1.00e-91	330.00
IUUC-Ete-032646	Echinops telfairi	86.99	4.00e-169	588.00
IUUC-Eca-033805	Equus caballus	94.79	0.00e+00	1251.00
IUUC-Eeu-035216	Erinaceus europaeus	94.90	1.00e-144	506.00
IUUC-Fca-035611	Felis catus	95.40	0.00e+00	1152.00
IUUC-Fal-037186	Ficedula albicollis	79.42	0.00e+00	993.00
IUUC-Gmo-038824	Gadus morhua	69.85	0.00e+00	627.00
IUUC-Gga-040875	Gallus gallus	81.23	0.00e+00	1103.00
IUUC-Gac-042226	Gasterosteus aculeatus	67.44	0.00e+00	928.00
IUUC-Ggo-045122	Gorilla gorilla	94.79	0.00e+00	1296.00
IUUC-Hsa-045882	Homo sapiens	94.79	0.00e+00	1295.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	95.88	0.00e+00	1280.00
IUUC-Lch-049960	Latimeria chalumnae	72.36	0.00e+00	998.00
IUUC-Loc-052408	Lepisosteus oculatus	76.43	0.00e+00	658.00
IUUC-Laf-054187	Loxodonta africana	95.20	0.00e+00	1242.00
IUUC-Mcc-055273	Macaca mulatta	94.24	0.00e+00	1266.00
IUUC-Meu-056267	Macropus eugenii	82.17	0.00e+00	1150.00
IUUC-Mga-059958	Meleagris gallopavo	87.58	2.00e-153	534.00
IUUC-Mmr-061280	Microcebus murinus	95.07	0.00e+00	1246.00
IUUC-Mdo-062625	Monodelphis domestica	88.48	0.00e+00	1254.00
IUUC-Mmu-063853	Mus musculus	92.59	0.00e+00	1264.00
IUUC-Mlu-067771	Myotis lucifugus	94.79	0.00e+00	1238.00
IUUC-Opr-070741	Ochotona princeps	95.06	0.00e+00	1294.00
IUUC-Ont-072172	Oreochromis niloticus	66.49	0.00e+00	936.00
IUUC-Oan-073167	Ornithorhynchus anatinus	79.48	0.00e+00	1128.00
IUUC-Ola-087203	Oryzias latipes	85.23	5.00e-134	470.00
IUUC-Oga-089153	Otolemur garnettii	94.46	0.00e+00	1253.00
IUUC-Oar-090008	Ovis aries	91.91	0.00e+00	1221.00
IUUC-Ptr-091234	Pan troglodytes	95.06	0.00e+00	1301.00
IUUC-Pan-092005	Papio anubis	95.20	0.00e+00	1294.00
IUUC-Psi-093995	Pelodiscus sinensis	84.42	0.00e+00	654.00
IUUC-Pma-094110	Petromyzon marinus	77.12	1.00e-64	241.00
IUUC-Pfo-097418	Poecilia formosa	65.53	0.00e+00	922.00
IUUC-Pab-098267	Pongo abelii	95.20	0.00e+00	1276.00
IUUC-Pca-101084	Procavia capensis	93.28	0.00e+00	1202.00
IUUC-Pva-102292	Pteropus vampyrus	95.15	0.00e+00	902.00
IUUC-Rno-105251	Rattus norvegicus	91.11	0.00e+00	1237.00
IUUC-Sha-107100	Sarcophilus harrisii	87.22	0.00e+00	1250.00
IUUC-Sar-113559	Sorex araneus	85.61	0.00e+00	1060.00
IUUC-Ssc-115688	Sus scrofa	94.79	0.00e+00	1274.00
IUUC-Tgu-117424	Taeniopygia guttata	79.78	0.00e+00	1116.00
IUUC-Tru-118585	Takifugu rubripes	67.30	0.00e+00	919.00
IUUC-Tsy-119299	Tarsius syrichta	83.21	0.00e+00	948.00
IUUC-Tni-120808	Tetraodon nigroviridis	66.80	0.00e+00	914.00
IUUC-Tbe-127705	Tupaia belangeri	94.09	1.00e-178	618.00
IUUC-Ttr-128225	Tursiops truncatus	94.24	0.00e+00	1226.00
IUUC-Vpa-130193	Vicugna pacos	95.67	1.00e-130	460.00
IUUC-Xtr-132449	Xenopus tropicalis	70.75	0.00e+00	933.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence