iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069232

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

ADFV01062650

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000004634.2	ENSNLET00000005956.2	ENSNLEP00000005663.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.20e-29	102.3	1018	1069

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
           +C+vC +++++e+ +++C++C++w+H+ C +l+ eee++n  +  + C+ Cr
   Q: 1018 SCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADigFDCSMCR 1069
           6********************************999999998899******8 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MDGLETTETE TIVETEIKEQ SAEEDAEAEV DNSKQLIPTL QRSVSEESAN SLVSVGVEAK 60
ISEQLCAFCY CGEKSSLGQG DLKQFRVTPG FILPWRNHPS NKKDIDDNSN GTYEKMQNSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTTAAGCC TTAAAATTTA ACATTTAACT CTATGTGCTT TTTTTTTTTT TTTTTTTTTT 60
TTTTTCTGTA GACCTCGAAG TAGGGGGAAA ACTGCAGTGG AAGATGAGGA CAGCATGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	85.96	0.00e+00	5458.00
IUUC-Apl-003311	Anas platyrhynchos	69.04	0.00e+00	4064.00
IUUC-Aca-004705	Anolis carolinensis	63.02	0.00e+00	3757.00
IUUC-Ame-010612	Astyanax mexicanus	70.55	0.00e+00	882.00
IUUC-Bta-012322	Bos taurus	80.66	0.00e+00	4983.00
IUUC-Cel-018354	Caenorhabditis elegans	35.38	4.00e-64	241.00
IUUC-Cja-019983	Callithrix jacchus	94.51	0.00e+00	6180.00
IUUC-Cfa-020903	Canis familiaris	85.13	0.00e+00	5539.00
IUUC-Cpo-021732	Cavia porcellus	80.18	0.00e+00	5123.00
IUUC-Csa-023083	Chlorocebus sabaeus	97.07	0.00e+00	8359.00
IUUC-Cho-024469	Choloepus hoffmanni	82.02	0.00e+00	2285.00
IUUC-Dre-028110	Danio rerio	56.65	0.00e+00	1447.00
IUUC-Dor-030569	Dipodomys ordii	79.30	0.00e+00	2966.00
IUUC-Dme-031590	Drosophila melanogaster	32.75	2.00e-64	241.00
IUUC-Eca-033945	Equus caballus	87.12	0.00e+00	5185.00
IUUC-Fca-035922	Felis catus	82.83	0.00e+00	5121.00
IUUC-Gmo-038719	Gadus morhua	73.14	0.00e+00	818.00
IUUC-Gac-041896	Gasterosteus aculeatus	43.90	0.00e+00	1791.00
IUUC-Ggo-044812	Gorilla gorilla	93.41	0.00e+00	6128.00
IUUC-Hsa-046595	Homo sapiens	96.79	0.00e+00	6371.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	84.49	0.00e+00	5240.00
IUUC-Lch-050086	Latimeria chalumnae	57.36	0.00e+00	2695.00
IUUC-Loc-052891	Lepisosteus oculatus	55.06	0.00e+00	2416.00
IUUC-Laf-054348	Loxodonta africana	82.78	0.00e+00	3078.00
IUUC-Mcc-054868	Macaca mulatta	96.25	0.00e+00	6273.00
IUUC-Meu-056322	Macropus eugenii	68.03	0.00e+00	1199.00
IUUC-Mga-059541	Meleagris gallopavo	69.03	0.00e+00	4158.00
IUUC-Mmr-061092	Microcebus murinus	90.40	0.00e+00	7765.00
IUUC-Mdo-062610	Monodelphis domestica	74.85	0.00e+00	1997.00
IUUC-Mmu-063666	Mus musculus	82.04	0.00e+00	5135.00
IUUC-Mpu-066366	Mustela putorius furo	82.14	0.00e+00	4894.00
IUUC-Mlu-068201	Myotis lucifugus	81.87	0.00e+00	4141.00
IUUC-Opr-070625	Ochotona princeps	77.16	0.00e+00	1326.00
IUUC-Ont-072401	Oreochromis niloticus	53.25	0.00e+00	1194.00
IUUC-Oan-072945	Ornithorhynchus anatinus	76.54	0.00e+00	6076.00
IUUC-Ocu-074920	Oryctolagus cuniculus	87.02	0.00e+00	7426.00
IUUC-Ola-086436	Oryzias latipes	44.11	0.00e+00	1765.00
IUUC-Oga-088637	Otolemur garnettii	86.04	0.00e+00	4541.00
IUUC-Oar-089363	Ovis aries	79.36	0.00e+00	4885.00
IUUC-Ptr-091527	Pan troglodytes	96.89	0.00e+00	6417.00
IUUC-Pan-092102	Papio anubis	93.29	0.00e+00	5991.00
IUUC-Pma-094252	Petromyzon marinus	44.53	3.00e-160	560.00
IUUC-Pfo-096288	Poecilia formosa	57.30	0.00e+00	1300.00
IUUC-Pab-098241	Pongo abelii	97.59	0.00e+00	3555.00
IUUC-Pca-100103	Procavia capensis	81.58	0.00e+00	1600.00
IUUC-Pva-102238	Pteropus vampyrus	77.12	0.00e+00	2576.00
IUUC-Rno-105395	Rattus norvegicus	75.98	0.00e+00	1120.00
IUUC-Sha-106550	Sarcophilus harrisii	76.10	0.00e+00	6269.00
IUUC-Sar-113183	Sorex araneus	61.98	9.00e-178	619.00
IUUC-Tgu-116677	Taeniopygia guttata	67.60	0.00e+00	3729.00
IUUC-Tru-118037	Takifugu rubripes	60.78	0.00e+00	1175.00
IUUC-Tsy-118932	Tarsius syrichta	88.58	0.00e+00	3623.00
IUUC-Tni-119970	Tetraodon nigroviridis	50.86	0.00e+00	1301.00
IUUC-Ttr-129051	Tursiops truncatus	83.64	0.00e+00	5136.00
IUUC-Vpa-130236	Vicugna pacos	83.17	0.00e+00	1977.00
IUUC-Xtr-132455	Xenopus tropicalis	52.47	0.00e+00	941.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence