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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046011
UUCD1 version UUC-HoS-01148
Ensembl Protein ID ENSP00000377655.2
UniProt Accession Q9BQF6; A1L3A5; A8MW39; B7WNW8; Q7Z3F4; Q96PS5; Q9C0F6; Q9HBT5; SENP7_HUMAN
Genbank Protein ID AAL25651.1; AAG09703.1; CAB66534.1; CAD97911.1; AAI29989.1; BAB21798.1
Protein Name Sentrin-specific protease 7; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7
Genbank Nucleotide ID AF199458; AF217504; AL136599; BX537943; AC068764; AB051494
Gene Name SENP7; KIAA1707; SSP2; SUSP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138468.15 ENST00000394095.6 ENSP00000377655.2
ENSG00000138468.15 ENST00000394091.5 ENSP00000377651.1
ENSG00000138468.15 ENST00000394094.6 ENSP00000377654.2
ENSG00000138468.15 ENST00000314261.11 ENSP00000313624.7
ENSG00000138468.15 ENST00000394085.7 ENSP00000377647.3
ENSG00000138468.15 ENST00000366089.2 ENSP00000402977.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDA
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 19392659
Classification
Family E-value Score Start End
DUB/ULP 3.10e-70 237.5 761 1003
Active Site
Position(s) Description Evidence
860 N/A {ECO:0000250}
992 {ECO:0000250}
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerr................rvktwtrkvdlfekdl 75
            vtnedl+cLeegeflnDviidfylkyl+lek+++e ver hifssffyk+l++ke++                rv+twtr++++f+kd+
   Q: 761  GVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNltednpnlsmaqrrhkRVRTWTRHINIFNKDY 850
           69******************************************************99******************************** PP
   S: 76   ifvpineaaHWslavvcf..............................................................kkksilllDS 103
           ifvp+ne++HW+lav+cf                                                              k+++il+lDS
   Q: 851  IFVPVNESSHWYLAVICFpwleeavyedfpqtvsqqsqaqqsqndnktidndlrttstlslsaedsqstesnmsvpkkmcKRPCILILDS 940
           ****************************************************************************************** PP
   S: 104  lrgasksnvvkklreylev..evkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyvesl 164
           l++as +n+v++lreylev  evk k++r+fsk+++ + +pkvp+Q+NssDCGvy+lqyves+
   Q: 941  LKAASVQNTVQNLREYLEVewEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESF 1003
           *******************999***************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
 Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
Protein Sequence
(Fasta)
MDKRKLGRRP SSSEIITEGK RKKSSSDLSE IRKMLNAKPE DVHVQSPLSK FRSSERWTLP 60
LQWERSLRNK VISLDHKNKK HIRGCPVTSK SSPERQLKVM LTNVLWTDLG RKFRKTLPRN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046011|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTTTTTTT TTTTTTTTTT TTTTTTTTCC TTTCCCCTCC CCCTCCCTCT CCAAGCCGGA 60
GGGGTCCTGA GGTGACAGCG CCTGCAACTG AAATTTCAGC AGCGGGAGAA GATGGACAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046011|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008234--F:cysteine-type peptidase activity
GO:0004930--F:G-protein coupled receptor activity
GO:0007188--P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
KEGG hsa:57337
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001517 Ailuropoda melanoleuca 84.99 0.00e+00 1717.00
IUUC-Atr-002817 Amborella trichopoda 32.06 5.00e-24 107.00
IUUC-Apl-003302 Anas platyrhynchos 46.79 0.00e+00 810.00
IUUC-Aca-005089 Anolis carolinensis 41.01 0.00e+00 667.00
IUUC-Aly-005759 Arabidopsis lyrata 27.15 7.00e-27 115.00
IUUC-Ath-006613 Arabidopsis thaliana 27.48 3.00e-28 120.00
IUUC-Ago-007729 Ashbya gossypii 27.00 1.00e-19 92.40
IUUC-Acl-008018 Aspergillus clavatus 40.52 1.00e-20 95.90
IUUC-Afl-008482 Aspergillus flavus 36.88 8.00e-20 93.20
IUUC-Ani-009366 Aspergillus nidulans 38.98 5.00e-21 97.10
IUUC-Ang-009744 Aspergillus niger 37.14 7.00e-16 80.10
IUUC-Ate-010553 Aspergillus terreus 38.24 5.00e-16 80.90
IUUC-Ame-011446 Astyanax mexicanus 48.86 2.00e-97 349.00
IUUC-Bgr-012266 Blumeria graminis 39.67 5.00e-19 90.50
IUUC-Bta-012652 Bos taurus 82.13 0.00e+00 1625.00
IUUC-Bdi-014139 Brachypodium distachyon 32.69 3.00e-26 114.00
IUUC-Bol-016126 Brassica oleracea 30.84 2.00e-25 111.00
IUUC-Bra-017420 Brassica rapa 29.47 7.00e-28 119.00
IUUC-Cja-018890 Callithrix jacchus 91.41 0.00e+00 1679.00
IUUC-Cfa-020923 Canis familiaris 84.54 0.00e+00 1679.00
IUUC-Cpo-022468 Cavia porcellus 77.24 0.00e+00 1336.00
IUUC-Cre-022651 Chlamydomonas reinhardtii 38.97 7.00e-20 93.20
IUUC-Csa-024235 Chlorocebus sabaeus 96.86 0.00e+00 1792.00
IUUC-Cho-024942 Choloepus hoffmanni 77.38 0.00e+00 815.00
IUUC-Cin-025522 Ciona intestinalis 40.80 8.00e-65 241.00
IUUC-Cgl-026623 Colletotrichum gloeosporioides 30.71 2.00e-24 108.00
IUUC-Cne-027012 Cryptococcus neoformans 39.32 3.00e-20 95.10
IUUC-Dre-027818 Danio rerio 38.77 1.00e-103 371.00
IUUC-Dno-029935 Dasypus novemcinctus 76.80 0.00e+00 783.00
IUUC-Dor-030139 Dipodomys ordii 60.40 4.00e-82 300.00
IUUC-Dme-031729 Drosophila melanogaster 41.28 4.00e-56 213.00
IUUC-Ete-032892 Echinops telfairi 72.30 0.00e+00 1023.00
IUUC-Eca-033398 Equus caballus 84.64 0.00e+00 1540.00
IUUC-Eeu-034595 Erinaceus europaeus 76.10 0.00e+00 1395.00
IUUC-Fca-036245 Felis catus 83.29 0.00e+00 1646.00
IUUC-Fal-036736 Ficedula albicollis 43.34 0.00e+00 687.00
IUUC-Fox-038045 Fusarium oxysporum 31.09 4.00e-28 120.00
IUUC-Fso-038416 Fusarium solani 32.39 2.00e-28 122.00
IUUC-Gmo-039168 Gadus morhua 36.77 3.00e-42 165.00
IUUC-Gga-040895 Gallus gallus 43.76 0.00e+00 714.00
IUUC-Gac-041712 Gasterosteus aculeatus 46.82 1.00e-78 286.00
IUUC-Gma-043078 Glycine max 31.23 3.00e-28 120.00
IUUC-Ggo-044423 Gorilla gorilla 99.14 0.00e+00 2035.00
IUUC-Hvu-047202 Hordeum vulgare 30.14 6.00e-17 80.90
IUUC-Itr-048853 Ictidomys tridecemlineatus 84.13 0.00e+00 1698.00
IUUC-Lch-050229 Latimeria chalumnae 45.44 6.00e-118 418.00
IUUC-Lpe-051158 Leersia perrieri 23.63 2.00e-19 91.30
IUUC-Loc-052810 Lepisosteus oculatus 39.79 1.00e-108 387.00
IUUC-Lma-053172 Leptosphaeria maculans 41.27 1.00e-19 92.80
IUUC-Laf-053556 Loxodonta africana 83.59 0.00e+00 1513.00
IUUC-Mcc-055633 Macaca mulatta 95.22 0.00e+00 1924.00
IUUC-Mtr-058560 Medicago truncatula 30.28 8.00e-21 96.30
IUUC-Mga-059926 Meleagris gallopavo 45.06 0.00e+00 708.00
IUUC-Mmr-061064 Microcebus murinus 87.13 0.00e+00 1749.00
IUUC-Mdo-061950 Monodelphis domestica 62.62 0.00e+00 1196.00
IUUC-Mmu-063995 Mus musculus 69.77 0.00e+00 1320.00
IUUC-Mac-065083 Musa acuminata 31.25 2.00e-26 114.00
IUUC-Mpu-066660 Mustela putorius furo 84.62 0.00e+00 1704.00
IUUC-Mlu-067173 Myotis lucifugus 83.39 0.00e+00 1505.00
IUUC-Nfi-068345 Neosartorya fischeri 39.52 2.00e-21 98.60
IUUC-Nle-070111 Nomascus leucogenys 97.24 0.00e+00 1948.00
IUUC-Opr-070785 Ochotona princeps 62.57 0.00e+00 998.00
IUUC-Ont-072672 Oreochromis niloticus 48.63 2.00e-96 345.00
IUUC-Oan-073520 Ornithorhynchus anatinus 53.90 0.00e+00 852.00
IUUC-Ocu-074146 Oryctolagus cuniculus 81.75 0.00e+00 1431.00
IUUC-Oba-075399 Oryza barthii 25.27 4.00e-20 93.20
IUUC-Obr-076515 Oryza brachyantha 32.04 2.00e-29 125.00
IUUC-Ogl-077267 Oryza glaberrima 31.73 8.00e-30 126.00
IUUC-Ogu-078425 Oryza glumaepatula 25.78 8.00e-19 89.00
IUUC-Oin-080091 Oryza indica 31.73 6.00e-30 126.00
IUUC-Olo-080689 Oryza longistaminata 25.37 9.00e-21 95.50
IUUC-Ome-081527 Oryza meridionalis 24.64 6.00e-20 92.80
IUUC-Oni-082476 Oryza nivara 25.74 7.00e-21 95.90
IUUC-Opu-084112 Oryza punctata 24.40 4.00e-19 90.10
IUUC-Oru-085206 Oryza rufipogon 25.37 1.00e-20 95.50
IUUC-Osa-086169 Oryza sativa 31.61 6.00e-30 126.00
IUUC-Olu-087762 Ostreococcus lucimarinus 30.50 1.00e-29 125.00
IUUC-Oga-088400 Otolemur garnettii 82.14 0.00e+00 1595.00
IUUC-Oar-090273 Ovis aries 81.62 0.00e+00 1610.00
IUUC-Ptr-090796 Pan troglodytes 99.24 0.00e+00 2036.00
IUUC-Pan-091782 Papio anubis 91.99 0.00e+00 1658.00
IUUC-Psi-093935 Pelodiscus sinensis 45.55 0.00e+00 686.00
IUUC-Pno-094801 Phaeosphaeria nodorum 43.14 2.00e-19 91.70
IUUC-Ppa-095171 Physcomitrella patens 30.82 2.00e-26 114.00
IUUC-Pfo-096792 Poecilia formosa 45.65 5.00e-88 319.00
IUUC-Pab-098505 Pongo abelii 93.43 0.00e+00 1868.00
IUUC-Pop-099422 Populus trichocarpa 31.80 6.00e-26 113.00
IUUC-Pca-100196 Procavia capensis 62.09 5.00e-178 618.00
IUUC-Ppe-101347 Prunus persica 29.26 6.00e-20 93.20
IUUC-Pva-102390 Pteropus vampyrus 79.24 0.00e+00 1498.00
IUUC-Pte-104039 Pyrenophora teres 30.41 2.00e-16 82.00
IUUC-Rno-105145 Rattus norvegicus 70.66 0.00e+00 1364.00
IUUC-Sce-106359 Saccharomyces cerevisiae 23.99 6.00e-16 80.10
IUUC-Sha-107054 Sarcophilus harrisii 62.78 0.00e+00 1072.00
IUUC-Sja-107700 Schizosaccharomyces japonicus 34.47 1.00e-34 141.00
IUUC-Spo-108052 Schizosaccharomyces pombe 33.44 3.00e-35 143.00
IUUC-Ssl-108654 Sclerotinia sclerotiorum 37.65 1.00e-12 68.60
IUUC-Smo-109565 Selaginella moellendorffii 30.19 3.00e-22 99.80
IUUC-Sit-110025 Setaria italica 31.25 3.00e-30 127.00
IUUC-Sly-111049 Solanum lycopersicum 29.43 8.00e-26 112.00
IUUC-Stu-111985 Solanum tuberosum 22.82 1.00e-10 61.20
IUUC-Sar-113324 Sorex araneus 90.20 0.00e+00 645.00
IUUC-Sre-115211 Sporisorium reilianum 36.84 2.00e-16 82.00
IUUC-Ssc-116333 Sus scrofa 83.65 0.00e+00 1677.00
IUUC-Tgu-116626 Taeniopygia guttata 57.23 8.00e-151 526.00
IUUC-Tsy-119022 Tarsius syrichta 81.85 0.00e+00 1553.00
IUUC-Tni-120181 Tetraodon nigroviridis 57.06 7.00e-53 200.00
IUUC-Tca-121659 Theobroma cacao 31.99 3.00e-22 100.00
IUUC-Tre-121879 Trichoderma reesei 29.87 2.00e-27 117.00
IUUC-Tvi-122488 Trichoderma virens 31.65 7.00e-30 126.00
IUUC-Tae-125285 Triticum aestivum 32.58 9.00e-32 132.00
IUUC-Tbe-127624 Tupaia belangeri 68.38 0.00e+00 691.00
IUUC-Ttr-129225 Tursiops truncatus 80.97 0.00e+00 1618.00
IUUC-Vda-129950 Verticillium dahliae 28.87 6.00e-24 106.00
IUUC-Vpa-130805 Vicugna pacos 84.11 0.00e+00 1602.00
IUUC-Xtr-132908 Xenopus tropicalis 58.26 2.00e-116 412.00
IUUC-Xma-133567 Xiphophorus maculatus 50.29 2.00e-96 346.00
Created Date 25-Jun-2017

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