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iUUCD ID | IUUC-Sce-106146 | ||||||||||||||||||||||||||||||||
UUCD1 version | UUC-SaC-00034 | ||||||||||||||||||||||||||||||||
Ensembl Protein ID | YJL047C | ||||||||||||||||||||||||||||||||
UniProt Accession | P47050; D6VWD7; CUL8_YEAST | ||||||||||||||||||||||||||||||||
Genbank Protein ID | AAQ91376.1; CAA89338.1; DAA08753.1 | ||||||||||||||||||||||||||||||||
Protein Name | Cullin-8; Cullin-C; Regulator of Ty1 transposition protein 101 | ||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | AY387707; Z49322; BK006943 | ||||||||||||||||||||||||||||||||
Gene Name | RTT101; CUL8; YJL047C; J1166 | ||||||||||||||||||||||||||||||||
Ensembl Information |
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Annotation |
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Status | Reviewed | ||||||||||||||||||||||||||||||||
Details |
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Organism | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||
Functional Description (View) |
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Ubiquitinates the FACT (facilitiates chromatin transcription) complex subunit SPT16 in an MMS1-independent manner. Involved in regulation of Ty1 transposition and protects the genome from Ty1 integration upstream of tRNA genes. | ||||||||||||||||||||||||||||||||
Protein Sequence (Fasta) |
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Nucleotide Sequence (Fasta) |
ATGATAAATG AGAGCGTTTC CAAGAGAGAA GGATTCCACG AGTCTATAAG CAGAGAGACG 60
AGTGCAAGCA ACGCTTTAGG ACTATACAAT AAATTTAACG ATGAGCGAAA TCCCAGGTAT 120 It may take some time, please wait.
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Sequence Source | Ensembl | ||||||||||||||||||||||||||||||||
Keyword | KW-0131--Cell cycle |
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Interpro | IPR016158--Cullin_homology |
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PROSITE | PS50069--CULLIN_2 |
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Pfam | PF00888--Cullin |
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SMART | SM00884--Cullin_Nedd8 |
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Gene Ontology | GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex |
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KEGG | sce:YJL047C | ||||||||||||||||||||||||||||||||
Orthology |
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Created Date | 25-Jun-2017 |